Search Results - "Nuñez, Raymundo"

Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening by Shishodia, Shifali, Nuñez, Raymundo, Strohmier, Brayden P., Bursch, Karina L., Goetz, Christopher J., Olp, Michael D., Jensen, Davin R., Fenske, Tyler G., Ordonez-Rubiano, Sandra C., Blau, Maya E., Roach, Mallory K., Peterson, Francis C., Volkman, Brian F., Dykhuizen, Emily C., Smith, Brian C.

“…PBRM1 is a subunit of the PBAF chromatin remodeling complex that uniquely contains six bromodomains. PBRM1 can operate as a tumor suppressor or tumor promoter…”
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Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression by Bursch, Karina L., Goetz, Christopher J., Jiao, Guanming, Nuñez, Raymundo, Olp, Michael D., Dhiman, Alisha, Khurana, Mallika, Zimmermann, Michael T., Urrutia, Raul A., Dykhuizen, Emily C., Smith, Brian C.

“…The polybromo, brahma-related gene 1–associated factors (PBAF) chromatin remodeling complex subunit polybromo-1 (PBRM1) contains six bromodomains that…”
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Fragment-based screening by protein-detected NMR spectroscopy by Kerber, Paul J, Nuñez, Raymundo, Jensen, Davin R, Zhou, Angela L, Peterson, Francis C, Hill, R Blake, Volkman, Brian F, Smith, Brian C

“…Fragment-based drug discovery (FBDD) identifies low molecular weight compounds that can be developed into ligands with high affinity and selectivity for…”
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Polybromo‐1 missense mutations found in renal cancer patients affect bromodomain stability and biological function by Jiao, Guanming, Goetz, Christopher, Bursch, Karina, Nuñez, Raymundo, Olp, Michael, Zimmerman, Michael, Urrutia, Raul, Smith, Brian, Dykhuizen, Emily

“…Chromatin structure is important in modulating gene expression. A central component of chromatin structure is the covalent post‐translational modification…”
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The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation by Nuñez, Raymundo, Sidlowski, Paul F. W., Steen, Erica A., Wynia-Smith, Sarah L., Sprague, Daniel J., Keyes, Robert F., Smith, Brian C.

“…Histone lysine lactylation (Kla) regulates inflammatory gene expression in activated macrophages and mediates the polarization of inflammatory (M1) to…”
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Abstract 1259: TRIM33 as a novel reader of metabolically-derived histone lactylation by Nunez, Raymundo, Smith, Brian

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Abstract 1294: Cancer-associated missense mutations in the tumor suppressor Polybromo-1 variably affect protein stability and function by Bursch, Karina, Goetz, Christopher, Nunez, Raymundo, Jiao, Guanming, Olp, Michael, Jorge, Salomão, Urrutia, Raul, Dykhuizen, Emily, Smith, Brian

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Zinc‐Chelating BET Bromodomain Inhibitors Selectively Accumulate and Affect Gene Expression in Pancreatic β‐Cells by Jones Lipinski, Rachel A., Stancill, Jennifer S., Wynia‐Smith, Sarah L., Sprague, Daniel J., Nunez, Raymundo, Bird, Amir, Corbett, John A., Smith, Brian C.

“…The islets of Langerhans are a heterogeneous mixture of endocrine (hormone‐secreting) cells in the mammalian pancreas. Of particular interest are the β‐cells…”
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Effect of CO2 on the generation of biomass and lipids by Monoraphidium contortum: A promising microalga for the production of biodiesel by Pineda-Camacho, Gabriela, Guillén-Jiménez, Flor de María, Pérez-Sánchez, Adriana, Raymundo-Núñez, Leticia Martha, Mendoza-Trinidad, Gabriela

“…In this work, the effect of different concentrations of CO2 (0.03, 2.5, 5.0, 7.5, and 10%) was evaluated on the generation of biomass, the productivity of…”
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Incorporación de tuétano de res en un champú para cabello y evaluación de su efecto contra la alopecia by Arroyo-Cruz, Uriel, de María Guillén-Jiménez, Flor, Mendoza-Trinidad, Gabriela, Pineda-Camacho, Gabriela, Raymundo-Núñez, Leticia Martha

“…La caída de cabello se genera por diferentes factores, y puede originar estrés emocional en las personas que la presentan. Con el objetivo de incorporar…”
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Dimensionamiento de un sistema hidraulico en casa-habitacion para el uso de agua residual by Ruiz-Cuello, Tatiana, Pescador-Piedra, Juan C, Raymundo-Núñez, Leticia M, Pineda-Camacho, Gabriela

“…Fue diseñado un sistema hidráulico de una casa-habitación para la reutilización de agua de uso doméstico por medio de la selección de las corrientes a tratar y…”
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Comportamiento Racional Ante Diferentes Mecanismos De intermediación Financiera by Ochoa Núñez, Mario Raymundo

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