Confounding role of comorbidities and COVID-19 vaccination uptake in clinical utility of hematological biomarkers in Cameroonian patients infected with SARS-CoV-2

•SARS-CoV-2 modulated the blood profile of Cameroonian populations.•Anisocytosis was the major hematological disorder (95.5%).•Normocytic normochromic anemia was predominant in SARS-CoV-2 positive patients.•The neutrophil-to-lymphocyte ratio was clinically useful for SARS-CoV-2 prognostic.•Improveme...

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Bibliographic Details
Published in:	IJID regions Vol. 8; pp. 129 - 136
Main Authors:	Moguem Soubgui, Arlette Flore, Kojom Foko, Loick Pradel, Embolo Enyegue, Elisée Libert, Ndeme Mboussi, Wilfried Steve, Mbebi Enone, Juste Patient, Ntatou Lemouchele, Idriss, Koanga Mogtomo, Martin Luther
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-09-2023 Elsevier
Subjects:	Cameroon Clinical value Coronavirus (COVID-19) Collection Hematological parameters SARS-CoV-2 Variation Clinical value SARS-CoV-2 Cameroon Variation Hematological parameters
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Summary:	•SARS-CoV-2 modulated the blood profile of Cameroonian populations.•Anisocytosis was the major hematological disorder (95.5%).•Normocytic normochromic anemia was predominant in SARS-CoV-2 positive patients.•The neutrophil-to-lymphocyte ratio was clinically useful for SARS-CoV-2 prognostic.•Improvement of the prognostic value of Neutrophil-to-lymphocyte ratio in participants with comorbidities. To analyze variations in blood profile, the extent of hematological disorders, and the impact of comorbidities and COVID-19 vaccination on blood profile parameters and their clinical value for prognostic of SARS-CoV-2 infection. This cross-sectional study took place in Douala, Cameroon. A complete blood count and molecular detection of SARS-CoV-2 were performed on patients. Clinical value was appraised using area under the curve (AUC) analysis. In total, 420 participants were included. A significant reduction of hematological parameters such as lymphocytes (p < 0.0001), red blood cells (P = 0.0025), mean corpuscular hemoglobin count (P < 0.0001), and platelets (P = 0.02) was seen in SARS-CoV-2 (+) patients. Anisocytosis was the main hematological disorder (95.5%). Normocytic normochromic anemia was predominant in SARS-CoV-2 (+) (35.3%) while microcytic normochromic anemia was more frequently seen in SARS-CoV-2 (-) (16.5%). Neutrophil-to-lymphocyte (NLR) consistently showed statistically significant AUC ∼0.75 upon stratification for age, gender, and comorbidities, with the exception of COVID-19 vaccination uptake. In a context where molecular detection methods are difficultly affordable in health facilities in developing countries such as Cameroon, NLR could be clinically interesting for identifying SARS-CoV-2 infected individuals, especially those with comorbidities.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2772-7076 2772-7076
DOI:	10.1016/j.ijregi.2023.08.003