737 Acute toxicity of the combination of postoperative chemotherapy (5FU-folinic acid) and radiotherapy in patients with rectal (Duke's B2, C) non-metastatic carcinoma
The aim of this study is the evaluation of the acute toxicity of chemotherapy and radiotherapy when they are combined postoperatively in patients with non-metastatic rectal carcinoma, stage B2, C or in early local recurrence. Thirty-six patients were studied (20 males, 16 females, medium age 63 year...
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| Published in: | European journal of cancer (1990) Vol. 31; p. S154 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Ltd
01-11-1995
|
| Online Access: | Get full text |
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| Summary: | The aim of this study is the evaluation of the acute toxicity of chemotherapy and radiotherapy when they are combined postoperatively in patients with non-metastatic rectal carcinoma, stage B2, C or in early local recurrence. Thirty-six patients were studied (20 males, 16 females, medium age 63 years). They all had been radically operated and were treated with a combination of six cycles of chemotherapy (5 FU
+
folinic Acid) and radiotherapy (XRT). Two cycles of chemotherapy were given prior to XRT, two cycles during XRT and two cycles thereafter. The medium XRT dose range was 5040 cGy while the medium 5FU dose range was 400
mg/m
2 and the folinic acid dose was 30
mg/m
2. The patients were analysed for acute toxicity during the treatment and up to 3‐6 months after it was completed. The following specific symptoms were evaluated to determine the tolerance of the treatment: Diarrhea, nausea, stomatitis, leucopenia, thrombocytopenia, anaemia.
Diarrhea
Moderate
24/36
66.6%
Severe
5/36
13.8%
Nausea
Mild
3/36
8.3%
Stomatitis
Mild
12/36
36.1%
Stomatitis
Moderate
10/36
28%
Leucopenia
Mild
7/36
19.4%
Thrombocytopenia
Mild
1/36
2.7%
Anaemia
Mild
2/36
5.5%
In conclusion the combination of postoperative chemotherapy and radiotherapy in patients with locally advanced (Duke's B2, C) or recurrence carcinoma of the rectum is well tolerated and easily implemented even in elderly patients. |
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| ISSN: | 0959-8049 1879-0852 |
| DOI: | 10.1016/0959-8049(95)95986-G |