Search Results - "Noy, Peter"

Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids by Matthews, Alexandra L., Noy, Peter J., Reyat, Jasmeet S., Tomlinson, Michael G.

“…A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are ubiquitous transmembrane "molecular scissors" which proteolytically cleave, or shed, the…”
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Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins by Matthews, Alexandra L, Szyroka, Justyna, Collier, Richard, Noy, Peter J, Tomlinson, Michael G

“…A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitously expressed transmembrane protein which is essential for embryonic development through activation…”
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The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex by Koo, Chek Ziu, Harrison, Neale, Noy, Peter J., Szyroka, Justyna, Matthews, Alexandra L., Hsia, Hung-En, Müller, Stephan A., Tüshaus, Johanna, Goulding, Joelle, Willis, Katie, Apicella, Clara, Cragoe, Bethany, Davis, Edward, Keles, Murat, Malinova, Antonia, McFarlane, Thomas A., Morrison, Philip R., Nguyen, Hanh T.H., Sykes, Michael C., Ahmed, Haroon, Di Maio, Alessandro, Seipold, Lisa, Saftig, Paul, Cull, Eleanor, Pliotas, Christos, Rubinstein, Eric, Poulter, Natalie S., Briddon, Stephen J., Holliday, Nicholas D., Lichtenthaler, Stefan F., Tomlinson, Michael G.

“…A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein essential for embryonic development, and its dysregulation underlies disorders such as…”
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The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation by Brummer, Tobias, Pigoni, Martina, Rossello, Armando, Wang, Huanhuan, Noy, Peter J., Tomlinson, Michael G., Blobel, Carl P., Lichtenthaler, Stefan F.

“…The transmembrane protein, ADAM10 (a disintegrin and metalloprotease 10), has key physiologic functions—for example, during embryonic development and in the…”
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Sprouting angiogenesis is regulated by shedding of the C‐type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid‐like 2 protein (RHBDL2) by Noy, Peter J., Swain, Rajeeb K., Khan, Kabir, Lodhia, Puja, Bicknell, Roy

“…ABSTRACT C‐type lectin family 14, member A (CLEC14A), is a single‐pass transmembrane glycoprotein that is overexpressed in tumor endothelial cells, and it…”
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TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS by Noy, Peter J, Yang, Jing, Reyat, Jasmeet S, Matthews, Alexandra L, Charlton, Alice E, Furmston, Joanna, Rogers, David A, Rainger, G Ed, Tomlinson, Michael G

“…A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitously expressed transmembrane metalloprotease that cleaves the extracellular regions from its…”
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TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice by Gotru, Sanjeev K, Chen, Wenchun, Kraft, Peter, Becker, Isabelle C, Wolf, Karen, Stritt, Simon, Zierler, Susanna, Hermanns, Heike M, Rao, Deviyani, Perraud, Anne-Laure, Schmitz, Carsten, Zahedi, René P, Noy, Peter J, Tomlinson, Michael G, Dandekar, Thomas, Matsushita, Masayuki, Chubanov, Vladimir, Gudermann, Thomas, Stoll, Guido, Nieswandt, Bernhard, Braun, Attila

“…OBJECTIVE—TRPM7 (transient receptor potential cation channel, subfamily M, member 7) is a ubiquitously expressed bifunctional protein comprising a transient…”
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ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration by Reyat, Jasmeet S, Chimen, Myriam, Noy, Peter J, Szyroka, Justyna, Rainger, G Ed, Tomlinson, Michael G

“…The recruitment of blood leukocytes across the endothelium to sites of tissue infection is central to inflammation, but also promotes chronic inflammatory…”
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Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells by Noy, Peter J., Gavin, Rebecca L., Colombo, Dario, Haining, Elizabeth J., Reyat, Jasmeet S., Payne, Holly, Thielmann, Ina, Lokman, Adam B., Neag, Georgiana, Yang, Jing, Lloyd, Tammy, Harrison, Neale, Heath, Victoria L., Gardiner, Chris, Whitworth, Katharine M., Robinson, Joseph, Koo, Chek Z., Di Maio, Alessandro, Harrison, Paul, Lee, Steven P., Michelangeli, Francesco, Kalia, Neena, Rainger, G. Ed, Nieswandt, Bernhard, Brill, Alexander, Watson, Steve P., Tomlinson, Michael G.

“…Ca 2+ entry via Orai1 store-operated Ca 2+ channels in the plasma membrane is critical to cell function, and Orai1 loss causes severe immunodeficiency and…”
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RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly by Wilson, Eleanor, Leszczynska, Katarzyna, Poulter, Natalie S, Edelmann, Francesca, Salisbury, Victoria A, Noy, Peter J, Bacon, Andrea, Rappoport, Joshua Z, Heath, John K, Bicknell, Roy, Heath, Victoria L

“…RhoJ is a Rho GTPase expressed in endothelial cells and tumour cells, which regulates cell motility, invasion, endothelial tube formation and focal adhesion…”
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Utilizing Lentiviral Gene Transfer in Primary Endothelial Cells to Assess Lymphocyte-Endothelial Interactions by Reyat, Jasmeet S, Tomlinson, Michael G, Noy, Peter J

“…A major impediment when studying primary human endothelial cell function is the resistance of these cells to gene transfer. Here we describe methods for…”
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Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation by Haining, Elizabeth J., Matthews, Alexandra L., Noy, Peter J., Romanska, Hanna M., Harris, Helen J., Pike, Jeremy, Morowski, Martina, Gavin, Rebecca L., Yang, Jing, Milhiet, Pierre-Emmanuel, Berditchevski, Fedor, Nieswandt, Bernhard, Poulter, Natalie S., Watson, Steve P., Tomlinson, Michael G.

“…The tetraspanins are a superfamily of four-transmembrane proteins, which regulate the trafficking, lateral diffusion and clustering of the transmembrane…”
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Tspan18 is a novel regulator of the Ca 2+ channel Orai1 and von Willebrand factor release in endothelial cells by Noy, Peter J, Gavin, Rebecca L, Colombo, Dario, Haining, Elizabeth J, Reyat, Jasmeet S, Payne, Holly, Thielmann, Ina, Lokman, Adam B, Neag, Georgiana, Yang, Jing, Lloyd, Tammy, Harrison, Neale, Heath, Victoria L, Gardiner, Chris, Whitworth, Katharine M, Robinson, Joseph, Koo, Chek Z, Di Maio, Alessandro, Harrison, Paul, Lee, Steven P, Michelangeli, Francesco, Kalia, Neena, Rainger, G Ed, Nieswandt, Bernhard, Brill, Alexander, Watson, Steve P, Tomlinson, Michael G

“…Ca entry Orai1 store-operated Ca channels in the plasma membrane is critical to cell function, and Orai1 loss causes severe immunodeficiency and developmental…”
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PRH/Hhex Controls Cell Survival through Coordinate Transcriptional Regulation of Vascular Endothelial Growth Factor Signaling by Noy, Peter, Williams, Hannah, Sawasdichai, Anyaporn, Gaston, Kevin, Jayaraman, Padma-Sheela

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transforming food systems in Maritime Southeast Asia and Pacific Small Island Developing States to support food security and sustainable healthy diets by Chin, Chiew Foan, Goh, Ee Von, Clarke, Andrew C., Ang, Michelle Li Ern, Show, Pau Loke, Supramaniam, Christina V., Ali, Asgar, Azam-Ali, Susan, Beyer, Richard, Culaba, Alvin, Munawaroh, Heli Siti Halimatul, Kairo, Kinaai, Khoo, Kuan Shiong, Khoo, Gaik Cheng, Matanjun, Patricia, Massawe, Festo, Lim, Miang H., Sankaran, Revathy, Sriariyanun, Malinee, Membrebe, Bernard Nino Q., Noy, Peter, Lechner, Alex M.

“…Food is one of the basic necessities for human life. Nutritious food is essential for human health and helps oneself live up to our best potential as…”
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The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors by Desjobert, Cecile, Noy, Peter, Swingler, Tracey, Williams, Hannah, Gaston, Kevin, Jayaraman, Padma-Sheela

“…The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a transcription factor that functions as an important…”
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Towards personalised rapid label free miRNA detection for cancer and liver injury diagnostics in cell lysates and blood based samples by Duffy, James, Padovani, Francesco, Brunetti, Giulio, Noy, Peter, Certa, Ulrich, Hegner, Martin

“…Advances in prevention, diagnosis and therapy are coupled to innovation and development of new medical tools, leading to improved patient prognosis. We…”
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Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to de-repress VEGF-signalling genes and promote cell survival by Noy, Peter, Sawasdichai, Anyaporn, Jayaraman, Padma-Sheela, Gaston, Kevin

“…Protein kinase CK2 promotes cell survival and the activity of this kinase is elevated in several cancers including chronic myeloid leukaemia. We have shown…”
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Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes by Noy, Peter, Gaston, Kevin, Jayaraman, Padma-Sheela

“…Abstract The PRH/Hhex transcription factor represses multiple genes in the VEGF signalling pathway (VSP) to inhibit myeloid cell survival. Protein kinase CK2…”
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CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding by Soufi, Abdenour, Noy, Peter, Buckle, Malcolm, Sawasdichai, Anyaporn, Gaston, Kevin, Jayaraman, Padma-Sheela

“…The proline-rich homeodomain protein (PRH/Hex) regulates transcription by binding to specific DNA sequences and regulates mRNA transport by binding to…”
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