Search Results - "Nowlan, N. C."

Differential effect of frequency and duration of mechanical loading on fetal chick cartilage and bone development by Khatib, N, Parisi, C, Nowlan, N C

“…Developmental engineering strategies aim to recapitulate aspects of development in vitro as a means of forming functional engineered tissues, including…”
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Prenatal murine skeletogenesis partially recovers from absent skeletal muscle as development progresses by Sotiriou, V, Huang, Y, Ahmed, S, Isaksson, H, Nowlan, N C

“…Skeletal muscle contractions are critical for normal skeletal growth and morphogenesis but it is unclear how the detrimental effects of absent muscle on the…”
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Initiation and emerging complexity of the collagen network during prenatal skeletal development by Ahmed, S, Nowlan, N C

“…The establishment of a complex collagen network is critical for the architecture and mechanical properties of cartilage and bone. However, when and how the key…”
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Biomechanics of foetal movement by Nowlan, N C

“…Foetal movements commence at seven weeks of gestation, with the foetal movement repertoire including twitches, whole body movements, stretches, isolated limb…”
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Prenatal muscle forces are necessary for vertebral segmentation and disc structure, but not for notochord involution in mice by Levillain, A, Ahmed, S, Kaimaki, D-M, Schuler, S, Barros, S, Labonte, D, Iatridis, J C, Nowlan, N C

“…Embryonic muscle forces are necessary for normal vertebral development and spinal curvature, but their involvement in intervertebral disc (IVD) development…”
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Short-term foetal immobility temporally and progressively affects chick spinal curvature and anatomy and rib development by Levillain, A, Rolfe, R A, Huang, Y, Iatridis, Y C, Nowlan, N C

“…Congenital spine deformities may be influenced by movements in utero, but the effects of foetal immobility on spine and rib development remain unclear. The…”
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Smaller, weaker, and less stiff bones evolve from changes in subsistence strategy by Nowlan, N. C., Jepsen, K. J., Morgan, E. F.

“…Summary We propose a computational model with which to examine the evolution of bone. Our results indicate that changes in subsistence strategy have influenced…”
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Evolution of mechanoregulation of bone growth will lead to non-optimal bone phenotypes by Nowlan, Niamh C., Prendergast, Patrick J.

“…Mechanical forces acting on the bones during growth affect their final shape and strength. Mechanoregulation of bone growth may be recognized in embryogenesis,…”
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Blocking mechanosensitive ion channels eliminates the effects of applied mechanical loading on chick joint morphogenesis by Parisi, Cristian, Chandaria, Vikesh V., Nowlan, Niamh C.

“…Abnormalities in joint shape are increasingly considered a critical risk factor for developing osteoarthritis in life. It has been shown that mechanical forces…”
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