Search Results - "Nowicky, J W"

Induction of bimodal programmed cell death in malignant cells by the derivative Ukrain (NSC-631570) by Liepins, A, Nowicky, J W, Bustamante, J O, Lam, E

“…Selective induction of malignant cell death is one of the major goals of effective and safe chemotherapy. Recent developments in the understanding of…”
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Antineoplastic drug NSC631570 modulates functions of hypoxic macrophages by Skivka, L M, Fedorchuk, O G, Rudyk, M P, Pozur, V V, Khranovska, N M, Grom, M Yu, Nowicky, J W

“…Hypoxia is an important factor in the macrophages microenvironment. Many physiological and pathological processes including solid tumor development are…”
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Modulation of immune effector cell cytolytic activity and tumour growth inhibition in vivo by Ukrain (NSC 631570) by Liepins, A, Nowicky, J W

“…Ukrain is a semisynthetic compound consisting of alkaloids from Chelidonium majus L. conjugated to thiophosphoric acid, with immunomodulatory and therapeutic…”
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Influence of Ukrain on DNA, RNA and protein synthesis in malignant cells by Nowicky, J W, Hiesmayr, W, Nowicky, W, Liepins, A

“…3H labelled thymidine, uridine and leucine were used to evaluate the synthesis of DNA, RNA and proteins in malignant cells and normal cells incubated with…”
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Ukrain: a novel antitumor drug by Uglyanitsa, K N, Nefyodov, L I, Doroshenko, Y M, Nowicky, J W, Volchek, I V, Brzosko, W J, Hodysh, Y J

“…A review of the recent literature on the new anticancer drug Ukrain is provided herein. We review Ukrain, a thiophosphate derivative of alkaloids from…”
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Effect of Ukrain preparation on immune response in mice affected by influenza virus by Ciebiada, I, Korczak, E, Denys, A, Nowicky, J W

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Absorption spectra and spectral-kinetic characteristics of the fluorescence of Sanguinarine in complexes with polyelectrolytes and DNA by Motevich, I. G., Strekal, N. D., Nowicky, J. W., Maskevich, S. A.

“…The absorption spectra and stationary and time resolved fluorescence spectra of the isoquinoline alkaloid sanguinarine are studied in aqueous media and during…”
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Radiomodification effects of Ukrain, a cytostatic and immunomodulating drug, on intracellular glucocorticoid reception during short-term gamma-irradiation by Luksa-Lichtenthaeler, G L, Ladutko, E I, Nowicky, J W

“…The ability of Ukrain, a cytostatic and immunomodulating semisynthetic compound of thiophosphate-modified alkaloids of Chelidonium majus L., to modify the…”
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Influence of Ukrain on human xenografts in vitro by Nowicky, J W, Hiesmayr, W, Nowicky, W, Liepins, A

“…Tumour cells were taken from human tumour xenografts (HTX) and serially transplanted into nude mice. These cells were used in a colony-forming assay in vitro…”
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Clinical aspects of cancer treatment and new biochemical mechanisms of the drug Ukrain by Uglyanitsa, K N, Nefyodov, L I, Karayedova, L M, Nowicky, J W, Brzosko, W

“…A random group of 50 patients in tumor stages T1-3N0-2M0 was selected from breast cancer patients and given Ukrain therapy by intravenous injection…”
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Influence of Ukrain on the nuclear thyroid hormone receptors after short-term gamma-irradiation by Luksa-Lichtenthaler, G L, Ladutko, E I, Nowicky, J W

“…The ability of Ukrain, a semi-synthetic alkaloid thiophosphoric acid derivative (NSC-631579), to influence thyroid hormone levels in plasma and nuclear thyroid…”
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Influence of Ukrain on immunological blood parameters in vitro and in vivo by Nowicky, J W, Hiesmayr, W, Liepins, A

“…Immunological changes are often seen in subjects suffering from oncological disease. Decreased NK activity, alterations of the T4/T8 quotient, decreased…”
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IR absorption and surface-enhanced Raman spectra of the isoquinoline alkaloid berberine by Strekal’, N. D., Motevich, I. G., Nowicky, J. W., Maskevich, S. A.

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Inhibitory effect of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. (Ukrain) on ovalbumin antigenicity and antiovalbumin IgE antibody response in mice by Wyczółkowska, J, Michoń, T, Nowicky, J W

“…The ability of the Chelidonium majus L. alkaloid derivative Ukrain (UK) to inhibit ovalbumin-induced sensitization was tested in BALB/c and F1(BALB/c x…”
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Does the Ukrain preparation protect mice against lethal doses of bacteria? by Ciebiada, I, Korczak, E, Nowicky, J W, Denys, A

“…Ukrain, a semi-synthetic preparation obtained from Chelidonium majus L, is used in the treatment of cancer diseases. It has been observed to exert a protective…”
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Biophysiological effects of Ukrain therapy in a patient with breast cancer (case report) by Schramm, E, Nowicky, J W, Godysh, Y

“…The effects on different biophysiological parameters and subjective impressions were studied in a patient with breast cancer who was not previously given any…”
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Evaluation of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. ("Ukrain") as an immunostimulant in patients with various carcinomas by Nowicky, J W, Staniszewski, A, Zbroja-Sontag, W, Slesak, B, Nowicky, W, Hiesmayr, W

“…This paper summarizes the preliminary results of two independent clinical trials conducted with the preparation "Ukrain", containing thiophosphoric acid…”
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Cysteine proteinase inhibitor level in tumor and normal tissues in control and cured mice by Poteryaeva, O N, Falameyeva, O V, Korolenko, T A, Kaledin, V I, Djanayeva, S J, Nowicky, J W, Sandula, J

“…Cystatin C is the best known extracellular endogenous cysteine proteinase inhibitor and has been studied as a possible index of tumor growth and as a marker of…”
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Antinociceptive effect of ten day administration of Ukrain in mice and interaction of the treatment with morphine by Jagiełło-Wojtowicz, E, Kleinrok, Z, Chodkowska, A, Nowicky, J W, Piper, H, Kubiatowski, T

“…The present study shows that Ukrain, administered i.c. in doses of 9.5 and 19 mg/kg once daily for 10 days in mice, produced evident antinociceptive action in…”
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Interaction between Ukrain and morphine in their ten-day treatment in mice in the writhing syndrome test by Jagiełło-Wojtowicz, E, Kleinrok, Z, Nowicky, J W, Chodkowska, A, Kubiatowski, T, Piper, H

“…The antinociceptive properties of Ukrain and of morphine in their 10 day treatment in mice were studied by the writhing syndrome test. It was found that the…”
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