Search Results - "Nowell, Cameron J"

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination by Le, Caroline P., Nowell, Cameron J., Kim-Fuchs, Corina, Botteri, Edoardo, Hiller, Jonathan G., Ismail, Hilmy, Pimentel, Matthew A., Chai, Ming G., Karnezis, Tara, Rotmensz, Nicole, Renne, Giuseppe, Gandini, Sara, Pouton, Colin W., Ferrari, Davide, Möller, Andreas, Stacker, Steven A., Sloan, Erica K.

“…Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives cancer progression, although the pathways of tumour cell dissemination…”
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NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells by Masters, Seth L., Gerlic, Motti, Metcalf, Donald, Preston, Simon, Pellegrini, Marc, O’Donnell, Joanne A., McArthur, Kate, Baldwin, Tracey M., Chevrier, Stephane, Nowell, Cameron J., Cengia, Louise H., Henley, Katya J., Collinge, Janelle E., Kastner, Daniel L., Feigenbaum, Lionel, Hilton, Douglas J., Alexander, Warren S., Kile, Benjamin T., Croker, Ben A.

“…Cytopenias are key prognostic indicators of life-threatening infection, contributing to immunosuppression and mortality. Here we define a role for…”
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Resolving subcellular pH with a quantitative fluorescent lifetime biosensor by Rennick, Joshua J., Nowell, Cameron J., Pouton, Colin W., Johnston, Angus P. R.

“…Changes in sub-cellular pH play a key role in metabolism, membrane transport, and triggering cargo release from therapeutic delivery systems. Most methods to…”
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Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors by Mor, Michael, Werbner, Michal, Alter, Joel, Safra, Modi, Chomsky, Elad, Lee, Jamie C, Hada-Neeman, Smadar, Polonsky, Ksenia, Nowell, Cameron J, Clark, Alex E, Roitburd-Berman, Anna, Ben-Shalom, Noam, Navon, Michal, Rafael, Dor, Sharim, Hila, Kiner, Evgeny, Griffis, Eric R, Gershoni, Jonathan M, Kobiler, Oren, Leibel, Sandra Lawrynowicz, Zimhony, Oren, Carlin, Aaron F, Yaari, Gur, Dessau, Moshe, Gal-Tanamy, Meital, Hagin, David, Croker, Ben A, Freund, Natalia T

“…The interactions between antibodies, SARS-CoV-2 and immune cells contribute to the pathogenesis of COVID-19 and protective immunity. To understand the…”
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Machine Learning for the Fast and Accurate Assessment of Fitness in Coral Early Life History by Macadam, Alex, Nowell, Cameron J., Quigley, Kate

“…As coral reefs continue to degrade globally due to climate change, considerable effort and investment is being put into coral restoration. The production of…”
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Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish by Pase, Luke, Layton, Judith E., Wittmann, Christine, Ellett, Felix, Nowell, Cameron J., Reyes-Aldasoro, Constantino Carlos, Varma, Sony, Rogers, Kelly L., Hall, Chris J., Keightley, M. Cristina, Crosier, Philip S., Grabher, Clemens, Heath, Joan K., Renshaw, Stephen A., Lieschke, Graham J.

“…Prompt neutrophil arrival is critical for host defense immediately after injury [1–3]. Following wounding, a hydrogen peroxide (H2O2) burst generated in…”
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Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells by Flanagan, Dustin J., Phesse, Toby J., Barker, Nick, Schwab, Renate H.M., Amin, Nancy, Malaterre, Jordane, Stange, Daniel E., Nowell, Cameron J., Currie, Scott A., Saw, Jarel T.S., Beuchert, Eva, Ramsay, Robert G., Sansom, Owen J., Ernst, Matthias, Clevers, Hans, Vincan, Elizabeth

“…The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is maintained by a pool of cycling stem cells intermingled with Paneth…”
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Physiological and pharmacological impact of oxytocin on epididymal propulsion during the ejaculatory process in rodents and men by Stadler, Beatrix, Nowell, Cameron J., Whittaker, Michael R., Arnhold, Stefan, Pilatz, Adrian, Wagenlehner, Florian M., Exintaris, Betty, Middendorff, Ralf

“…During the emission phase of ejaculation, the sperm is driven from the cauda epididymidis, where it is stored, through the vas deferens by strong contractions…”
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Air-Liquid-Interface Differentiated Human Nose Epithelium: A Robust Primary Tissue Culture Model of SARS-CoV-2 Infection by Tran, Bang M, Grimley, Samantha L, McAuley, Julie L, Hachani, Abderrahman, Earnest, Linda, Wong, Sharon L, Caly, Leon, Druce, Julian, Purcell, Damian F J, Jackson, David C, Catton, Mike, Nowell, Cameron J, Leonie, Laura, Deliyannis, Georgia, Waters, Shafagh A, Torresi, Joseph, Vincan, Elizabeth

“…The global urgency to uncover medical countermeasures to combat the COVID-19 pandemic caused by the severe acute respiratory syndrome-coronavirus 2…”
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Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A (KIF1A) by Kaur, Simranpreet, Van Bergen, Nicole J., Verhey, Kristen J., Nowell, Cameron J., Budaitis, Breane, Yue, Yang, Ellaway, Carolyn, Brunetti‐Pierri, Nicola, Cappuccio, Gerarda, Bruno, Irene, Boyle, Lia, Nigro, Vincenzo, Torella, Annalaura, Roscioli, Tony, Cowley, Mark J., Massey, Sean, Sonawane, Rhea, Burton, Matthew D., Schonewolf‐Greulich, Bitten, Tümer, Zeynep, Chung, Wendy K., Gold, Wendy A., Christodoulou, John

“…Defects in the motor domain of kinesin family member 1A (KIF1A), a neuron‐specific ATP‐dependent anterograde axonal transporter of synaptic cargo, are…”
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Inhibition of the KCa3.1 Channel Alleviates Established Pulmonary Fibrosis in a Large Animal Model by Organ, Louise, Bacci, Barbara, Koumoundouros, Emmanuel, Kimpton, Wayne G, Samuel, Chrishan S, Nowell, Cameron J, Bradding, Peter, Roach, Katy M, Westall, Glen, Jaffar, Jade, Snibson, Ken J

“…Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease of increasing prevalence marked by poor prognosis and limited treatment options…”
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No observed effect on brain vasculature of Alzheimer's disease-related mutations in the zebrafish presenilin 1 gene by Barthelson, Karissa, Newman, Morgan, Nowell, Cameron J, Lardelli, Michael

“…Previously, we found that brains of adult zebrafish heterozygous for Alzheimer's disease-related mutations in their presenilin 1 gene (psen1, orthologous to…”
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The Wiggle Index: An Open Source Bioassay to Assess Sub-Lethal Insecticide Response in Drosophila melanogaster by Denecke, Shane, Nowell, Cameron J, Fournier-Level, Alexandre, Perry, Trent, Batterham, Phil

“…Toxicological assays measuring mortality are routinely used to describe insecticide response, but sub-lethal exposures to insecticides can select for…”
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Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1 by Croker, Ben A, O'Donnell, Joanne A, Nowell, Cameron J, Metcalf, Donald, Dewson, Grant, Campbell, Kirsteen J, Rogers, Kelly L, Hu, Yifang, Smyth, Gordon K, Zhang, Jian-Guo, White, Michael, Lackovic, Kurt, Cengia, Louise H, O'Reilly, Lorraine A, Bouillet, Philippe, Cory, Suzanne, Strasser, Andreas, Roberts, Andrew W

“…During immune responses, neutrophils must integrate survival and death signals from multiple sources to regulate their lifespan. Signals that activate either…”
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Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling by Williams, Steven P, Odell, Adam F, Karnezis, Tara, Farnsworth, Rae H, Gould, Cathryn M, Li, Jason, Paquet-Fifield, Sophie, Harris, Nicole C, Walter, Anne, Gregory, Julia L, Lamont, Sara F, Liu, Ruofei, Takano, Elena A, Nowell, Cameron J, Bower, Neil I, Resnick, Daniel, Smyth, Gordon K, Coultas, Leigh, Hogan, Benjamin M, Fox, Stephen B, Mueller, Scott N, Simpson, Kaylene J, Achen, Marc G, Stacker, Steven A

“…Lymphatic vessels constitute a specialized vasculature that is involved in development, cancer, obesity, and immune regulation. The migration of lymphatic…”
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A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth by FARNSWORTH, Rae H, KARNEZIS, Tara, SHAYAN, Ramin, MATSUMOTO, Masataka, NOWELL, Cameron J, ACHEN, Marc G, STACKER, Steven A

“…Lymph node metastasis, an early and prognostically important event in the progression of many human cancers, is associated with expression of VEGF-D. Changes…”
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Rosiglitazone and a β3-Adrenoceptor Agonist Are Both Required for Functional Browning of White Adipocytes in Culture by Merlin, Jon, Sato, Masaaki, Chia, Ling Yeong, Fahey, Richard, Pakzad, Mohsen, Nowell, Cameron J., Summers, Roger J., Bengtsson, Tore, Evans, Bronwyn A., Hutchinson, Dana S.

“…The recruitment of brite (or beige) adipocytes has been advocated as a means to combat obesity, due to their ability to phenotypically resemble brown…”
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Using a Multiplex Nucleic Acid in situ Hybridization Technique to Determine HCN4 mRNA Expression in the Adult Rodent Brain by Oyrer, Julia, Bleakley, Lauren E., Richards, Kay L., Maljevic, Snezana, Phillips, A. Marie, Petrou, Steven, Nowell, Cameron J., Reid, Christopher A.

“…Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels carry a non-selective cationic conductance, Ih, which is important for modulating neuron…”
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Visualising functional 5-HT3 receptors containing A and C subunits at or near the cell surface by Abad, Isaiah P.L., Fam, Ray L., Nguyen, Dan-Thanh, Nowell, Cameron J., Trinh, Phuc N.H., Manallack, David T., Freihat, Lubna A., Chakrabarti, Jay, Jamil, Aamani, Exintaris, Betty, Yaakob, Nor S., Irving, Helen R.

“…[Display omitted] •5-HT3 receptor A and C subunits influence clinical responses to ligands.•A and C subunits with intracellular fluorescent protein inserts…”
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Mouse models for dominant dystrophic epidermolysis bullosa (DDEB) carrying common human point mutations recapitulate the human disease by Smith, B R C, Nystrom, A, Nowell, C J, Hausser, I, Gretzmeier, C, Robertson, S J, Varigos, G A, Has, C, Kern, J S, Pang, K C

“…Heterozygous missense mutations in the human COL7A1 gene - coding for collagen VII - lead to the rare, dominantly inherited skin disorder dominant dystrophic…”
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