Effects of feeding various tocotrienol sources on plasma lipids and aortic atherosclerotic lesions in cholesterol-fed rabbits

Effects of feeding various tocotrienol sources on plasma lipids and aortic atherosclerotic lesions in cholesterol-fed rabbits

Tocotrienols exert hypocholesterolaemic and antioxidant effects, and may hence have anti-atherogenic properties. Therefore, the aim of this study was to investigate the cholesterol-lowering and anti-atherogenic effects of tocotrienols in cholesterol-fed rabbits. Rabbits were fed a basal diet (contro...

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Bibliographic Details
Published in:Food research international Vol. 35; no. 2-3; pp. 245 - 251
Main Authors: Hasselwander, Oliver, Krämer, Klaus, Hoppe, Peter P, Oberfrank, Uwe, Baldenius, Kai, Schröder, Hartwig, Kaufmann, Wolfgang, Bahnemann, Rainer, Nowakowsky, Brigitte
Format: Journal Article Conference Proceeding
Language:English
Published: Oxford Elsevier Ltd 2002
Elsevier
Subjects:
Atherosclerosis
Biological and medical sciences
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
General pharmacology
Lipids
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plasma cholesterol
Tocotrienols
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Lipids
Tocotrienols
Plasma cholesterol
Atherosclerosis
Nutrition
Rat
Cholesterolemia
Rodentia
Vitamin
Cardiovascular disease
Cholesterol LDL
Supplemented diet
E-Vitamins
Antioxidant
Biological activity
Feeding
Prevention
Vertebrata
Mammalia
Absorption
Cholesterol HDL
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Summary:Tocotrienols exert hypocholesterolaemic and antioxidant effects, and may hence have anti-atherogenic properties. Therefore, the aim of this study was to investigate the cholesterol-lowering and anti-atherogenic effects of tocotrienols in cholesterol-fed rabbits. Rabbits were fed a basal diet (control) supplemented with γ-tocotrienol, γ-tocotrienyl acetate, mixed tocotrienols or α-tocotrienol for 12 weeks. All treatments resulted in significant increases in plasma tocotrienols. None of the treatments, however, had significant effects on serum lipids or size of atherosclerotic lesions. A trend towards a decrease in plasma cholesterol was observed following γ-tocotrienol treatment (−22%) after 6 weeks. The decrease was mainly attributable to a reduction in LDL cholesterol (23%), whereas HDL cholesterol increased (14%). This trend was mirrored in a non-significant reduction in lesion area (20%). Our results demonstrate that tocotrienols are absorbed, but have little effect on plasma lipids and atherosclerosis in cholesterol-fed rabbits.
ISSN:0963-9969
1873-7145
DOI:10.1016/S0963-9969(01)00192-2