Search Results - "Nowakowski, Tomasz Jan"
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The Long Noncoding RNA Pnky Regulates Neuronal Differentiation of Embryonic and Postnatal Neural Stem Cells
Published in Cell stem cell (02-04-2015)“…While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are known. Here, we identify…”
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MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain
Published in Proceedings of the National Academy of Sciences - PNAS (23-04-2013)“…Cerebral cortical neurons arise from radial glia (direct neurogenesis) or from intermediate progenitors (indirect neurogenesis); intriguingly, the sizes of…”
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Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma
Published in Cell stem cell (02-01-2020)“…Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor invasion, we created a…”
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Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior
Published in Molecular psychiatry (01-01-2024)“…The Wnt/β-catenin pathway contains multiple high-confidence risk genes that are linked to neurodevelopmental disorders, including autism spectrum disorder…”
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Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon
Published in PloS one (03-08-2011)“…Early telencephalic development involves transformation of neuroepithelial stem cells into radial glia, which are themselves neuronal progenitors, around the…”
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Loss of functional Dicer in mouse radial glia cell-autonomously prolongs cortical neurogenesis
Published in Developmental biology (15-10-2013)“…Radial glia of the mouse cerebral cortex emerge from neuroepithelial stem cells around embryonic day 11 and produce excitatory cortical neurons until a few…”
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Building blocks of the human brain
Published in Science (American Association for the Advancement of Science) (12-10-2018)“…Area-specific excitatory neuron subtypes emerge before sensory experience Classical computer software programs perform tasks in series: One algorithm has to be…”
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Single-cell analysis of prenatal and postnatal human cortical development
Published in Science (American Association for the Advancement of Science) (13-10-2023)“…We analyzed >700,000 single-nucleus RNA sequencing profiles from 106 donors during prenatal and postnatal developmental stages and identified lineage-specific…”
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Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices
Published in Nature neuroscience (15-11-2024)“…Seizures are made up of the coordinated activity of networks of neurons, suggesting that control of neurons in the pathologic circuits of epilepsy could allow…”
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Roles of the microrna pathway in cortical development
Published 01-01-2012“…Dicer endoribonuclease catalyzes the maturation of microRNAs (miRNAs) from double stranded precursors. Studies conditionally inactivating Dicer in the mouse…”
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Dissertation -
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01-P027 Investigating the roles of dicer1 endoribonuclease in embryonic organogenesis of mouse retina
Published in Mechanisms of development (01-08-2009)Get full text
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