Search Results - "Novozhilov, Artem S"

Origin and Evolution of the Universal Genetic Code by Koonin, Eugene V, Novozhilov, Artem S

“…The standard genetic code (SGC) is virtually universal among extant life forms. Although many deviations from the universal code exist, particularly in…”
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Origin and evolution of the genetic code: The universal enigma by Koonin, Eugene V., Novozhilov, Artem S.

“…The genetic code is nearly universal, and the arrangement of the codons in the standard codon table is highly nonrandom. The three main concepts on the origin…”
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How trait distributions evolve in populations with parametric heterogeneity by P Karev, Georgy, S Novozhilov, Artem

“…•Evolution of trait distributions is studied.•Heterogeneous models with parametric heterogeneity are analyzed.•Constant in time variance implies the normal…”
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On the spread of epidemics in a closed heterogeneous population by Novozhilov, Artem S.

“…Heterogeneity is an important property of any population experiencing a disease. Here we apply general methods of the theory of heterogeneous populations to…”
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Biological applications of the theory of birth-and-death processes by Novozhilov, Artem S, Karev, Georgy P, Koonin, Eugene V

“…In this review, we discuss applications of the theory of birth-and-death processes to problems in biology, primarily, those of evolutionary genomics. The…”
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Linear algebra of the permutation invariant Crow–Kimura model of prebiotic evolution by Bratus, Alexander S., Novozhilov, Artem S., Semenov, Yuri S.

“…•A purely algebraic approach to the Crow–Kimura model is elaborated.•A parametric solution to the Crow–Kimura model is found.•The model with the single peaked…”
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Evolution of the genetic code: partial optimization of a random code for robustness to translation error in a rugged fitness landscape by Novozhilov, Artem S, Wolf, Yuri I, Koonin, Eugene V

“…The standard genetic code table has a distinctly non-random structure, with similar amino acids often encoded by codons series that differ by a single…”
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Exceptional error minimization in putative primordial genetic codes by Novozhilov, Artem S, Koonin, Eugene V

“…The standard genetic code is redundant and has a highly non-random structure. Codons for the same amino acids typically differ only by the nucleotide in the…”
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Mathematical modeling of tumor therapy with oncolytic viruses: regimes with complete tumor elimination within the framework of deterministic models by Novozhilov, Artem S, Berezovskaya, Faina S, Koonin, Eugene V, Karev, Georgy P

“…Oncolytic viruses that specifically target tumor cells are promising anti-cancer therapeutic agents. The interaction between an oncolytic virus and tumor cells…”
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Mathematical modeling of tumor therapy with oncolytic viruses: effects of parametric heterogeneity on cell dynamics by Karev, Georgy P, Novozhilov, Artem S, Koonin, Eugene V

“…One of the mechanisms that ensure cancer robustness is tumor heterogeneity, and its effects on tumor cells dynamics have to be taken into account when studying…”
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Generalized quasispecies model on finite metric spaces: isometry groups and spectral properties of evolutionary matrices by Semenov, Yuri S., Novozhilov, Artem S.

“…The quasispecies model introduced by Eigen in 1971 has close connections with the isometry group of the space of binary sequences relative to the Hamming…”
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Exact solutions for the selection–mutation equilibrium in the Crow–Kimura evolutionary model by Semenov, Yuri S., Novozhilov, Artem S.

“…•We find stationary distributions of the Crow–Kimura model for specific fitness landscapes.•We propose a generating function method for the equilibrium…”
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On Eigen’s Quasispecies Model, Two-Valued Fitness Landscapes, and Isometry Groups Acting on Finite Metric Spaces by Semenov, Yuri S., Novozhilov, Artem S.

“…A two-valued fitness landscape is introduced for the classical Eigen’s quasispecies model. This fitness landscape can be considered as a direct generalization…”
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On the behavior of the leading eigenvalue of Eigen’s evolutionary matrices by Semenov, Yuri S., Bratus, Alexander S., Novozhilov, Artem S.

“…•A purely algebraic approach to the Eigen quasispecies model is elaborated.•Exact expressions for the mean population fitness are found.•Upper and lower bounds…”
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Solutions with a bounded support promote permanence of a distributed replicator equation by Bratus, Alexander S., Posvyanskii, Vladimir P., Novozhilov, Artem S.

“…The now classical replicator equation describes a wide variety of biological phenomena, including those in theoretical genetics, evolutionary game theory, or…”
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Mathematical modeling of evolution of horizontally transferred genes by Novozhilov, Artem S, Karev, Georgy P, Koonin, Eugene V

“…We describe a stochastic birth-and-death model of evolution of horizontally transferred genes in microbial populations. The model is a generalization of the…”
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On Diffusive Stability of Eigen’s Quasispecies Model by Bratus, Alexander S., Hu, Chin-Kun, Safro, Mikhail V., Novozhilov, Artem S.

“…Eigen’s quasispecies system with explicit space and global regulation is considered. Limit behavior and stability of the system in a functional space under…”
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Population models with singular equilibrium by Berezovskaya, Faina S., Novozhilov, Artem S., Karev, Georgy P.

“…A class of models of biological population and communities with a singular equilibrium at the origin is analyzed; it is shown that these models can possess a…”
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On the asymptotic behaviour of the solutions to the replicator equation by Karev, Georgy P, Novozhilov, Artem S, Berezovskaya, Faina S

“…Selection systems and the corresponding replicator equations model the evolution of replicators with a high level of abstraction. In this paper, we apply novel…”
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Existence and stability of stationary solutions to spatially extended autocatalytic and hypercyclic systems under global regulation and with nonlinear growth rates by Bratus’, Alexander S., Posvyanskii, Vladimir P., Novozhilov, Artem S.

“…An analytical analysis of spatially extended autocatalytic and hypercyclic systems is presented. It is shown that spatially explicit systems in the form of…”
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