Search Results - "Novoa, Jose M."

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease by Grande, M Teresa, Sánchez-Laorden, Berta, López-Blau, Cristina, De Frutos, Cristina A, Boutet, Agnès, Arévalo, Miguel, Rowe, R Grant, Weiss, Stephen J, López-Novoa, José M, Nieto, M Angela

“…During renal fibrosis, epithelial cells undergo a partial epithelial-to-mesenchymal transition that can be targeted to reverse established disease. Progressive…”
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Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects by López-Hernández, Francisco J, López-Novoa, Jose M

“…Transforming growth factor beta (TGF-β) has been recognized as an important mediator in the genesis of chronic kidney diseases (CKD), which are characterized…”
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Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants by Simões, Eric A F, Forleo-Neto, Eduardo, Geba, Gregory P, Kamal, Mohamed, Yang, Feng, Cicirello, Helen, Houghton, Matthew R, Rideman, Ronald, Zhao, Qiong, Benvin, Sarah L, Hawes, Alicia, Fuller, Erin D, Wloga, Elzbieta, Pizarro, Jose M Novoa, Munoz, Flor M, Rush, Scott A, McLellan, Jason S, Lipsich, Leah, Stahl, Neil, Yancopoulos, George D, Weinreich, David M, Kyratsous, Christos A, Sivapalasingam, Sumathi

“…Respiratory syncytial virus (RSV) is a major cause of childhood medically attended respiratory infection (MARI). We conducted a randomized, double-blind,…”
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Fibroblast activation and myofibroblast generation in obstructive nephropathy by López-Novoa, José M, Grande, María T

“…Activation of local resident fibroblasts and generation of myofibroblasts via epithelial–mesenchymal transition are key processes in the development of the…”
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Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway by Morales, Ana I., Detaille, Dominique, Prieto, Marta, Puente, Angel, Briones, Elsa, Arévalo, Miguel, Leverve, Xavier, López-Novoa, José M., El-Mir, Mohamad-Yehia

“…The antidiabetic drug metformin can diminish apoptosis induced by oxidative stress in endothelial cells and prevent vascular dysfunction even in nondiabetic…”
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An integrative view on the role of TGF-β in the progressive tubular deletion associated with chronic kidney disease by García-Sánchez, Omar, López-Hernández, Francisco J., López-Novoa, José M.

“…Transforming growth factor-β (TGF-β) is a cytokine known to participate in several processes related to the development of chronic kidney disease (CKD),…”
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Human endoglin as a potential new partner involved in platelet–endothelium interactions by Rossi, Elisa, Pericacho, Miguel, Bachelot-Loza, Christilla, Pidard, Dominique, Gaussem, Pascale, Poirault-Chassac, Sonia, Blanco, Francisco J., Langa, Carmen, González-Manchón, Consuelo, Novoa, Jose M. Lopez, Smadja, David M., Bernabeu, Carmelo

“…Complex interactions between platelets and activated endothelium occur during the thrombo-inflammatory reaction at sites of vascular injuries and during…”
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TGF-β/BMP proteins as therapeutic targets in renal fibrosis. Where have we arrived after 25 years of trials and tribulations? by Muñoz-Félix, José M, González-Núñez, María, Martínez-Salgado, Carlos, López-Novoa, José M

“…The understanding of renal fibrosis in chronic kidney disease (CKD) remains as a challenge. More than 10% of the population of developed countries suffer from…”
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Differential effect of quercetin on cisplatin-induced toxicity in kidney and tumor tissues by Sánchez-González, Penélope D., López-Hernández, Francisco J., Dueñas, Montserrat, Prieto, Marta, Sánchez-López, Elsa, Thomale, Jürgen, Ruiz-Ortega, Marta, López-Novoa, José M., Morales, Ana I.

“…Strategies to minimize the nephrotoxicity of platinated antineoplastics without affecting its antitumour efficacy are strongly necessary to improve the…”
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An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin by Quiros, Yaremi, Vicente-Vicente, Laura, Morales, Ana I, López-Novoa, José M, López-Hernández, Francisco J

“…Gentamicin is an aminoglycoside antibiotic widely used against infections by Gram-negative microorganisms. Nephrotoxicity is the main limitation to its…”
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Pregnancy-Induced High Plasma Levels of Soluble Endoglin in Mice Lead to Preeclampsia Symptoms and Placental Abnormalities by Pérez-Roque, Lucía, Núñez-Gómez, Elena, Rodríguez-Barbero, Alicia, Bernabéu, Carmelo, López-Novoa, José M, Pericacho, Miguel

“…Preeclampsia is a pregnancy-specific disease of high prevalence characterized by the onset of hypertension, among other maternal or fetal signs. Its…”
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The role of endoglin in post-ischemic revascularization by Núñez-Gómez, Elena, Pericacho, Miguel, Ollauri-Ibáñez, Claudia, Bernabéu, Carmelo, López-Novoa, José M.

“…Following arterial occlusion, blood vessels respond by forming a new network of functional capillaries (angiogenesis), by reorganizing preexisting capillaries…”
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Endoglin-based biological therapy in the treatment of angiogenesis-dependent pathologies by Ollauri-Ibáñez, Claudia, López-Novoa, José M, Pericacho, Miguel

“…Alterations in the process of angiogenesis, either by excess or by defect, are present in different common pathologies. For this reason, great efforts are…”
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Subcellular targets of cisplatin cytotoxicity: an integrated view by Sancho-Martínez, Sandra M, Prieto-García, Laura, Prieto, Marta, López-Novoa, José M, López-Hernández, Francisco J

“…Cisplatin is a chemotherapeutic drug widely used against a variety of cancers. Its clinical utility is severely limited by its toxicity, which mainly affects,…”
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Impaired erythropoietin synthesis in chronic kidney disease is caused by alterations in extracellular matrix composition by Olmos, Gemma, Muñoz‐Félix, José M., Mora, Inés, Müller, Anton Gerhard, Ruiz‐Torres, Maria Piedad, López‐Novoa, José M., Rodríguez‐Puyol, Diego

“…Renal fibrosis and anaemia are two of the most relevant events in chronic kidney disease. Fibrosis is characterized by the accumulation of extracellular matrix…”
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Continuous endoglin (CD105) overexpression disrupts angiogenesis and facilitates tumor cell metastasis by Ollauri-Ibáñez, Claudia, Núñez-Gómez, Elena, Egido-Turrión, Cristina, Silva-Sousa, Laura, Díaz-Rodríguez, Elena, Rodríguez-Barbero, Alicia, López-Novoa, José M., Pericacho, Miguel

“…Endoglin (CD105) is an auxiliary receptor for members of the TFG-β superfamily. Whereas it has been demonstrated that the deficiency of endoglin leads to minor…”
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Glomerular nephrotoxicity of aminoglycosides by Martínez-Salgado, Carlos, López-Hernández, Francisco J., López-Novoa, José M.

“…Aminoglycoside antibiotics are the most commonly used antibiotics worldwide in the treatment of Gram-negative bacterial infections. However, aminoglycosides…”
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Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients by Blázquez-Medela, Ana M, García-Ortiz, Luis, Gómez-Marcos, Manuel A, Recio-Rodríguez, José I, Sánchez-Rodríguez, Angel, López-Novoa, José M, Martínez-Salgado, Carlos

“…Endoglin is involved in the regulation of endothelial function, but there are no studies concerning its relation with hypertension- and diabetes-associated…”
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Impaired Tubular Reabsorption Is the Main Mechanism Explaining Increases in Urinary NGAL Excretion Following Acute Kidney Injury in Rats by Sancho-Martínez, Sandra M, Blanco-Gozalo, Víctor, Quiros, Yaremi, Prieto-García, Laura, Montero-Gómez, María J, Docherty, Neil G, Martínez-Salgado, Carlos, Morales, Ana I, López-Novoa, José M, López-Hernández, Francisco J

“…Abstract Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted low-molecular weight iron-siderophore-binding protein. NGAL overexpression in injured…”
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N-acetylcysteine transforms necrosis into apoptosis and affords tailored protection from cisplatin cytotoxicity by Sancho-Martínez, Sandra M., Prieto-García, Laura, Prieto, Marta, Fuentes-Calvo, Isabel, López-Novoa, José M., Morales, Ana I., Martínez-Salgado, Carlos, López-Hernández, Francisco J.

“…Nephrotoxicity is the main limitation to the dosage and anticancer efficacy of cisplatin. Cisplatin produces tubular epithelial cell apoptosis and necrosis…”
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