Search Results - "Novitskiy, Sergey"

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival by Özdemir, Berna C., Pentcheva-Hoang, Tsvetelina, Carstens, Julienne L., Zheng, Xiaofeng, Wu, Chia-Chin, Simpson, Tyler R., Laklai, Hanane, Sugimoto, Hikaru, Kahlert, Christoph, Novitskiy, Sergey V., De Jesus-Acosta, Ana, Sharma, Padmanee, Heidari, Pedram, Mahmood, Umar, Chin, Lynda, Moses, Harold L., Weaver, Valerie M., Maitra, Anirban, Allison, James P., LeBleu, Valerie S., Kalluri, Raghu

“…Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal myofibroblasts, but their functional contribution remains unknown…”
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Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer by Raz, Yael, Cohen, Noam, Shani, Ophir, Bell, Rachel E, Novitskiy, Sergey V, Abramovitz, Lilach, Levy, Carmit, Milyavsky, Michael, Leider-Trejo, Leonor, Moses, Harold L, Grisaru, Dan, Erez, Neta

“…Cancer-associated fibroblasts (CAFs) are highly prominent in breast tumors, but their functional heterogeneity and origin are still largely unresolved. We…”
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Adenosine/TGFβ axis in regulation of mammary fibroblast functions by Vasiukov, Georgii, Menshikh, Anna, Owens, Philip, Novitskaya, Tatiana, Hurley, Paula, Blackwell, Timothy, Feoktistov, Igor, Novitskiy, Sergey V.

“…Cancer associated fibroblasts (CAF) play a key role in cancer progression and metastasis. Diminished TGFβ response on CAF correlates with poor outcome and…”
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SMAD4 Suppresses Colitis-associated Carcinoma Through Inhibition of CCL20/CCR6-mediated Inflammation by Hanna, David N., Smith, Paula Marincola, Novitskiy, Sergey V., Washington, M. Kay, Zi, Jinghuan, Weaver, Connie J., Hamaamen, Jalal A., Lewis, Keeli B., Zhu, Jing, Yang, Jing, Liu, Qi, Beauchamp, R. Daniel, Means, Anna L.

“…We previously reported that colon epithelial cell silencing of Smad4 increased epithelial expression of inflammatory genes, including the chemokine c-c motif…”
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Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression by Laklai, Hanane, Miroshnikova, Yekaterina A, Pickup, Michael W, Collisson, Eric A, Kim, Grace E, Barrett, Alex S, Hill, Ryan C, Lakins, Johnathon N, Schlaepfer, David D, Mouw, Janna K, LeBleu, Valerie S, Roy, Nilotpal, Novitskiy, Sergey V, Johansen, Julia S, Poli, Valeria, Kalluri, Raghu, Iacobuzio-Donahue, Christine A, Wood, Laura D, Hebrok, Matthias, Hansen, Kirk, Moses, Harold L, Weaver, Valerie M

“…Impaired TGF-β signaling due to SMAD4 mutation in PDAC tumors initiates a STAT3-dependent signaling cascade that leads to increased stromal stiffening and…”
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Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells by Ryzhov, Sergey, Novitskiy, Sergey V, Goldstein, Anna E, Biktasova, Asel, Blackburn, Michael R, Biaggioni, Italo, Dikov, Mikhail M, Feoktistov, Igor

“…Extracellular adenosine and purine nucleotides are elevated in many pathological situations associated with the expansion of CD11b(+)Gr1(+) myeloid-derived…”
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Switching off CD73: a way to boost the activity of conventional and targeted antineoplastic therapies by Antonioli, Luca, Novitskiy, Sergey V., Sachsenmeier, Kris F., Fornai, Matteo, Blandizzi, Corrado, Haskó, György

“…•CD73 supports cancer onset and progression via an ‘adenosine halo’.•Preclinical studies highlighted CD73 as a useful target for cancer management.•CD73…”
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Characterization of Immunopathology and Small Airway Remodeling in Constrictive Bronchiolitis by Gutor, Sergey S, Richmond, Bradley W, Du, Rui-Hong, Wu, Pingsheng, Lee, Jae Woo, Ware, Lorraine B, Shaver, Ciara M, Novitskiy, Sergey V, Johnson, Joyce E, Newman, John H, Rennard, Stephen I, Miller, Robert F, Blackwell, Timothy S, Polosukhin, Vasiliy V

“…Constrictive bronchiolitis (ConB) is a relatively rare and understudied form of lung disease whose underlying immunopathology remains incompletely defined. Our…”
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Brief report: STING expressed in tumor and non-tumor compartments has distinct roles in regulating anti-tumor immunity by Kim, Jennie C., Liu, Xian, Fitzgerald, Karen, Eng, Jason S., Orf, Jessica, O’Brien, Sarah A., Belmontes, Brian, Casbon, Amy-Jo, Novitskiy, Sergey V., Tarbell, Kristin V., DeVoss, Jason, Egen, Jackson G.

“…Type I interferon-mediated activation of immune cells can facilitate the generation of productive tumor antigen-specific T cell responses in solid tumors. The…”
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Myeloid Cell-Derived TGFβ Signaling Regulates ECM Deposition in Mammary Carcinoma via Adenosine-Dependent Mechanisms by Vasiukov, Georgii, Novitskaya, Tatiana, Zijlstra, Andries, Owens, Philip, Ye, Fei, Zhao, Zhiguo, Moses, Harold L, Blackwell, Timothy, Feoktistov, Igor, Novitskiy, Sergey V

“…TGFβ plays a crucial role in the tumor microenvironment by regulating cell-cell and cell-stroma interactions. We previously demonstrated that TGFβ signaling on…”
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Loss of CXCR4 in Myeloid Cells Enhances Antitumor Immunity and Reduces Melanoma Growth through NK Cell and FASL Mechanisms by Yang, Jinming, Kumar, Amrendra, Vilgelm, Anna E, Chen, Sheau-Chiann, Ayers, Gregory D, Novitskiy, Sergey V, Joyce, Sebastian, Richmond, Ann

“…The chemokine receptor, CXCR4, is involved in cancer growth, invasion, and metastasis. Several promising CXCR4 antagonists have been shown to halt tumor…”
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Role of TGF-β signaling in generation of CD39+CD73+ myeloid cells in tumors by Ryzhov, Sergey V, Pickup, Michael W, Chytil, Anna, Gorska, Agnieszka E, Zhang, Qinkun, Owens, Philip, Feoktistov, Igor, Moses, Harold L, Novitskiy, Sergey V

“…There is growing evidence that generation of adenosine from ATP, which is mediated by the CD39/CD73 enzyme pair, predetermines immunosuppressive and…”
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Lipid accumulation and dendritic cell dysfunction in cancer by Gabrilovich, Dmitry I, Herber, Donna L, Cao, Wei, Nefedova, Yulia, Novitskiy, Sergey V, Nagaraj, Srinivas, Tyurin, Vladimir A, Corzo, Alex, Cho, Hyun-Il, Celis, Esteban, Lennox, Brianna, Knight, Stella C, Padhya, Tapan, McCaffrey, Thomas V, McCaffrey, Judith C, Antonia, Scott, Fishman, Mayer, Ferris, Robert L, Kagan, Valerian E

“…Dendritic cells in individuals with cancer and in mouse tumor models show an increase in triacylglycerides that seems to impair their antigen-processing…”
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Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss by Jolly, Lee Ann, Novitskiy, Sergey, Owens, Phillip, Massoll, Nicole, Cheng, Nikki, Fang, Wei, Moses, Harold L, Franco, Aime T

“…Contributions of the tumor microenvironment (TME) to progression in thyroid cancer are largely unexplored and may illuminate a basis for understanding rarer…”
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Adenosine receptors in regulation of dendritic cell differentiation and function by Novitskiy, Sergey V., Ryzhov, Sergey, Zaynagetdinov, Rinat, Goldstein, Anna E., Huang, Yuhui, Tikhomirov, Oleg Y., Blackburn, Michael R., Biaggioni, Italo, Carbone, David P., Feoktistov, Igor, Dikov, Mikhail M.

“…Differentiation of functional dendritic cells (DCs) critically depends on the microenvironment. DCs differentiate in hypoxic tumor sites and inflamed or…”
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Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival by Özdemir, Berna C., Pentcheva-Hoang, Tsvetelina, Carstens, Julienne L., Zheng, Xiaofeng, Wu, Chia-Chin, Simpson, Tyler R., Laklai, Hanane, Sugimoto, Hikaru, Kahlert, Christoph, Novitskiy, Sergey V., De Jesus-Acosta, Ana, Sharma, Padmanee, Heidari, Pedram, Mahmood, Umar, Chin, Lynda, Moses, Harold L., Weaver, Valerie M., Maitra, Anirban, Allison, James P., LeBleu, Valerie S., Kalluri, Raghu

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A requirement for p120-catenin in the metastasis of invasive ductal breast cancer by Kurley, Sarah J, Tischler, Verena, Bierie, Brian, Novitskiy, Sergey V, Noske, Aurelia, Varga, Zsuzsanna, Zürrer-Härdi, Ursina, Brandt, Simone, Carnahan, Robert H, Cook, Rebecca S, Muller, William J, Richmond, Ann, Reynolds, Albert B

“…We report here the effects of targeted p120-catenin (encoded by ; hereafter denoted p120) knockout (KO) in a PyMT mouse model of invasive ductal (mammary)…”
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PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses by Sai, Jiqing, Owens, Philip, Novitskiy, Sergey V, Hawkins, Oriana E, Vilgelm, Anna E, Yang, Jinming, Sobolik, Tammy, Lavender, Nicole, Johnson, Andrew C, McClain, Colt, Ayers, Gregory D, Kelley, Mark C, Sanders, Melinda, Mayer, Ingrid A, Moses, Harold L, Boothby, Mark, Richmond, Ann

“…Metastatic breast cancers continue to elude current therapeutic strategies, including those utilizing PI3K inhibitors. Given the prominent role of PI3Kα,β in…”
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Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion by Owens, Philip, Polikowsky, Hannah, Pickup, Michael W, Gorska, Agnieszka E, Jovanovic, Bojana, Shaw, Aubie K, Novitskiy, Sergey V, Hong, Charles C, Moses, Harold L

“…Bone Morphogenetic Proteins (BMPs) are secreted cytokines that are part of the Transforming Growth Factor β (TGFβ) superfamily. BMPs have been shown to be…”
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Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties by Novitskiy, Sergey V., Pickup, Michael W., Chytil, Anna, Polosukhina, Dina, Owens, Philip, Moses, Harold L.

“…Specific deletion of TGF‐β receptor II in macrophages, CD11b+Gr1+, and dendritic cells inhibit tumor growth by increasing efficiency of the immune system. By…”
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