Search Results - "Novitch, Bennett G."

Identification of neural oscillations and epileptiform changes in human brain organoids by Samarasinghe, Ranmal A., Miranda, Osvaldo A., Buth, Jessie E., Mitchell, Simon, Ferando, Isabella, Watanabe, Momoko, Allison, Thomas F., Kurdian, Arinnae, Fotion, Namie N., Gandal, Michael J., Golshani, Peyman, Plath, Kathrin, Lowry, William E., Parent, Jack M., Mody, Istvan, Novitch, Bennett G.

“…Brain organoids represent a powerful tool for studying human neurological diseases, particularly those that affect brain growth and structure. However, many…”
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Sox9 and NFIA Coordinate a Transcriptional Regulatory Cascade during the Initiation of Gliogenesis by Kang, Peng, Lee, Hyun Kyoung, Glasgow, Stacey M., Finley, Meggie, Donti, Tataka, Gaber, Zachary B., Graham, Brett H., Foster, Aaron E., Novitch, Bennett G., Gronostajski, Richard M., Deneen, Benjamin

“…Transcriptional cascades that operate over the course of lineage development are fundamental mechanisms that control cellular differentiation. In the…”
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ERK Inhibition Rescues Defects in Fate Specification of Nf1-Deficient Neural Progenitors and Brain Abnormalities by Wang, Yuan, Kim, Edward, Wang, Xiaojing, Novitch, Bennett G., Yoshikawa, Kazuaki, Chang, Long-Sheng, Zhu, Yuan

“…Germline mutations in the RAS/ERK signaling pathway underlie several related developmental disorders collectively termed neuro-cardio-facial-cutaneous (NCFC)…”
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Notch Activity Modulates the Responsiveness of Neural Progenitors to Sonic Hedgehog Signaling by Kong, Jennifer H., Yang, Linlin, Dessaud, Eric, Chuang, Katherine, Moore, Destaye M., Rohatgi, Rajat, Briscoe, James, Novitch, Bennett G.

“…Throughout the developing nervous system, neural stem and progenitor cells give rise to diverse classes of neurons and glia in a spatially and temporally…”
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Foxp-Mediated Suppression of N-Cadherin Regulates Neuroepithelial Character and Progenitor Maintenance in the CNS by Rousso, David L., Pearson, Caroline Alayne, Gaber, Zachary B., Miquelajauregui, Amaya, Li, Shanru, Portera-Cailliau, Carlos, Morrisey, Edward E., Novitch, Bennett G.

“…Neuroepithelial attachments at adherens junctions are essential for the self-renewal of neural stem and progenitor cells and the polarized organization of the…”
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Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling by Niewiadomski, Pawel, Kong, Jennifer H, Ahrends, Robert, Ma, Yan, Humke, Eric W, Khan, Sohini, Teruel, Mary N, Novitch, Bennett G, Rohatgi, Rajat

“…Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal development and cancer. We describe a program of multisite…”
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Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection by Watanabe, Momoko, Buth, Jessie E., Vishlaghi, Neda, de la Torre-Ubieta, Luis, Taxidis, Jiannis, Khakh, Baljit S., Coppola, Giovanni, Pearson, Caroline A., Yamauchi, Ken, Gong, Danyang, Dai, Xinghong, Damoiseaux, Robert, Aliyari, Roghiyh, Liebscher, Simone, Schenke-Layland, Katja, Caneda, Christine, Huang, Eric J., Zhang, Ye, Cheng, Genhong, Geschwind, Daniel H., Golshani, Peyman, Sun, Ren, Novitch, Bennett G.

“…The human cerebral cortex possesses distinct structural and functional features that are not found in the lower species traditionally used to model brain…”
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25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model by Li, Chunfeng, Deng, Yong-Qiang, Wang, Shuo, Ma, Feng, Aliyari, Roghiyh, Huang, Xing-Yao, Zhang, Na-Na, Watanabe, Momoko, Dong, Hao-Long, Liu, Ping, Li, Xiao-Feng, Ye, Qing, Tian, Min, Hong, Shuai, Fan, Junwan, Zhao, Hui, Li, Lili, Vishlaghi, Neda, Buth, Jessie E., Au, Connie, Liu, Ying, Lu, Ning, Du, Peishuang, Qin, F. Xiao-Feng, Zhang, Bo, Gong, Danyang, Dai, Xinghong, Sun, Ren, Novitch, Bennett G., Xu, Zhiheng, Qin, Cheng-Feng, Cheng, Genhong

“…Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV…”
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Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics by Sagner, Andreas, Gaber, Zachary B, Delile, Julien, Kong, Jennifer H, Rousso, David L, Pearson, Caroline A, Weicksel, Steven E, Melchionda, Manuela, Mousavy Gharavy, S Neda, Briscoe, James, Novitch, Bennett G

“…During tissue development, multipotent progenitors differentiate into specific cell types in characteristic spatial and temporal patterns. We addressed the…”
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Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog by Dessaud, Eric, Ribes, Vanessa, Balaskas, Nikolaos, Yang, Lin Lin, Pierani, Alessandra, Kicheva, Anna, Novitch, Bennett G, Briscoe, James, Sasai, Noriaki

“…Morphogens are secreted signalling molecules that act in a graded manner to control the pattern of cellular differentiation in developing tissues. An example…”
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Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism by Briscoe, James, Mynett, Anita, Ribeiro, Ana, Novitch, Bennett G, Cox, Barny, Ulloa, Fausto, Hill, Katy, Dessaud, Eric, Yang, Lin Lin

“…Morphogens act in developing tissues to control the spatial arrangement of cellular differentiation. The activity of a morphogen has generally been viewed as a…”
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Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube by Briscoe, James, Novitch, Bennett G

“…in vitro…”
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New perspectives on the mechanisms establishing the dorsal-ventral axis of the spinal cord by Andrews, Madeline G, Kong, Jennifer, Novitch, Bennett G, Butler, Samantha J

“…Distinct classes of neurons arise at different positions along the dorsal-ventral axis of the spinal cord leading to spinal neurons being segregated along this…”
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Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS) by Sangwan, Smriti, Zhao, Anni, Adams, Katrina L., Jayson, Christina K., Sawaya, Michael R., Guenther, Elizabeth L., Pan, Albert C., Ngo, Jennifer, Moore, Destaye M., Soriaga, Angela B., Do, Thanh D., Goldschmidt, Lukasz, Nelson, Rebecca, Bowers, Michael T., Koehler, Carla M., Shaw, David E., Novitch, Bennett G., Eisenberg, David S.

“…Fibrils and oligomers are the aggregated protein agents of neuronal dysfunction in ALS diseases. Whereas we now know much about fibril architecture, atomic…”
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Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates by Pearson, Caroline Alayne, Moore, Destaye M., Tucker, Haley O., Dekker, Joseph D., Hu, Hui, Miquelajáuregui, Amaya, Novitch, Bennett G.

“…The laminar architecture of the mammalian neocortex depends on the orderly generation of distinct neuronal subtypes by apical radial glia (aRG) during…”
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Coordinated Actions of the Forkhead Protein Foxp1 and Hox Proteins in the Columnar Organization of Spinal Motor Neurons by Rousso, David L., Gaber, Zachary B., Wellik, Deneen, Morrisey, Edward E., Novitch, Bennett G.

“…The formation of locomotor circuits depends on the spatially organized generation of motor columns that innervate distinct muscle and autonomic nervous system…”
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The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation by Linares, Anthony J, Lin, Chia-Ho, Damianov, Andrey, Adams, Katrina L, Novitch, Bennett G, Black, Douglas L

“…The RNA-binding proteins PTBP1 and PTBP2 control programs of alternative splicing during neuronal development. PTBP2 was found to maintain embryonic splicing…”
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Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells by Adams, Katrina L., Rousso, David L., Umbach, Joy A., Novitch, Bennett G.

“…Spinal motor neurons (MNs) control diverse motor tasks including respiration, posture and locomotion that are disrupted by neurodegenerative diseases such as…”
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Directed Differentiation of Human‐Induced Pluripotent Stem Cells Generates Active Motor Neurons by Karumbayaram, Saravanan, Novitch, Bennett G., Patterson, Michaela, Umbach, Joy A., Richter, Laura, Lindgren, Anne, Conway, Anne E., Clark, Amander T., Goldman, Steve A., Plath, Kathrin, Wiedau‐pazos, Martina, Kornblum, Harley I., Lowry, William E.

“…The potential for directed differentiation of human‐induced pluripotent stem (iPS) cells to functional postmitotic neuronal phenotypes is unknown. Following…”
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PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors by Gaber, Zachary B, Butler, Samantha J, Novitch, Bennett G

“…Distinct classes of neurons and glial cells in the developing spinal cord arise at specific times and in specific quantities from spatially discrete neural…”
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