Search Results - "Novikoff, Aaron"

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists by Novikoff, Aaron, O'Brien, Shannon L., Bernecker, Miriam, Grandl, Gerald, Kleinert, Maximilian, Knerr, Patrick J., Stemmer, Kerstin, Klingenspor, Martin, Zeigerer, Anja, DiMarchi, Richard, Tschöp, Matthias H., Finan, Brian, Calebiro, Davide, Müller, Timo D.

“…We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including…”
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Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity by Jall, Sigrid, De Angelis, Meri, Lundsgaard, Anne-Marie, Fritzen, Andreas M., Nicolaisen, Trine S., Klein, Anders B., Novikoff, Aaron, Sachs, Stephan, Richter, Erik A., Kiens, Bente, Schramm, Karl-Werner, Tschöp, Matthias H., Stemmer, Kerstin, Clemmensen, Christoffer, Müller, Timo D., Kleinert, Maximilian

“…Aims/hypothesis Treatment with the α3β4 nicotinic acetylcholine receptor (nAChR) agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), improves glucose…”
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Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice by Akindehin, Seun, Liskiewicz, Arkadiusz, Liskiewicz, Daniela, Bernecker, Miriam, Garcia-Caceres, Cristina, Drucker, Daniel J., Finan, Brian, Grandl, Gerald, Gutgesell, Robert, Hofmann, Susanna M., Khalil, Ahmed, Liu, Xue, Cota, Perla, Bakhti, Mostafa, Czarnecki, Oliver, Bastidas-Ponce, Aimée, Lickert, Heiko, Kang, Lingru, Maity, Gandhari, Novikoff, Aaron, Parlee, Sebastian, Pathak, Ekta, Schriever, Sonja C., Sterr, Michael, Ussar, Siegfried, Zhang, Qian, DiMarchi, Richard, Tschöp, Matthias H., Pfluger, Paul T., Douros, Jonathan D., Müller, Timo D.

“…The glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) signaling, but the underlying mechanisms remain…”
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TRPM7 kinase is required for insulin production and compensatory islet responses during obesity by Khajavi, Noushafarin, Beck, Andreas, Riçku, Klea, Beyerle, Philipp, Jacob, Katharina, Syamsul, Sabrina F, Belkacemi, Anouar, Reinach, Peter S, Schreier, Pascale Cf, Salah, Houssein, Popp, Tanja, Novikoff, Aaron, Breit, Andreas, Chubanov, Vladimir, Müller, Timo D, Zierler, Susanna, Gudermann, Thomas

“…Most overweight individuals do not develop diabetes due to compensatory islet responses to restore glucose homeostasis. Therefore, regulatory pathways that…”
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The molecular pharmacology of glucagon agonists in diabetes and obesity by Novikoff, Aaron, Müller, Timo D.

“…Within recent decades glucagon receptor (GcgR) agonism has drawn attention as a therapeutic tool for the treatment of type 2 diabetes and obesity. In both mice…”
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Antagonizing GIPR adds fire to the GLP-1R flame by Novikoff, Aaron, Müller, Timo D.

“…Unimolecular co-agonists at the GLP-1/GIP receptors have recently achieved remarkable anti-obesogenic feats; yet, in a recent Phase 1 clinical trial, Véniant…”
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Recent achievements and future directions of anti-obesity medications by Grandl, Gerald, Novikoff, Aaron, Liu, Xue, Müller, Timo D.

“…Pharmacological management of obesity long suffered from a reputation of a ‘Mission Impossible,’ with inefficient weight loss and/or unacceptable tolerability…”
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Why are we still in need for novel anti-obesity medications? by Novikoff, Aaron, Grandl, Gerald, Liu, Xue, D. Müller, Timo

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Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes by Sekar, Revathi, Motzler, Karsten, Kwon, Yun, Novikoff, Aaron, Jülg, Julia, Najafi, Bahar, Wang, Surui, Warnke, Anna-Luisa, Seitz, Susanne, Hass, Daniela, Gancheva, Sofiya, Kahl, Sabine, Yang, Bin, Finan, Brian, Schwarz, Kathrin, Okun, Juergen G., Roden, Michael, Blüher, Matthias, Müller, Timo D., Krahmer, Natalie, Behrends, Christian, Plettenburg, Oliver, Miaczynska, Marta, Herzig, Stephan, Zeigerer, Anja

“…During mammalian energy homeostasis, the glucagon receptor (Gcgr) plays a key role in regulating both glucose and lipid metabolisms. However, the mechanisms by…”
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Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes by Sekar, Revathi, Motzler, Karsten, Kwon, Yun, Novikoff, Aaron, Jülg, Julia, Najafi, Bahar, Wang, Surui, Warnke, Anna-Luisa, Seitz, Susanne, Hass, Daniela, Gancheva, Sofiya, Kahl, Sabine, Yang, Bin, Finan, Brian, Schwarz, Kathrin, Okun, Juergen G, Roden, Michael, Blüher, Matthias, Müller, Timo D, Krahmer, Natalie, Behrends, Christian, Plettenburg, Oliver, Miaczynska, Marta, Herzig, Stephan, Zeigerer, Anja

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The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets by El, Kimberley, Douros, Jonathan D., Willard, Francis S., Novikoff, Aaron, Sargsyan, Ashot, Perez-Tilve, Diego, Wainscott, David B., Yang, Bin, Chen, Alex, Wothe, Donald, Coupland, Callum, Tschöp, Mattias H., Finan, Brian, D’Alessio, David A., Sloop, Kyle W., Müller, Timo D., Campbell, Jonathan E.

“…The incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) mediate insulin responses that are proportionate to…”
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Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice by Liskiewicz, Arkadiusz, Khalil, Ahmed, Liskiewicz, Daniela, Novikoff, Aaron, Grandl, Gerald, Maity-Kumar, Gandhari, Gutgesell, Robert M., Bakhti, Mostafa, Bastidas-Ponce, Aimée, Czarnecki, Oliver, Makris, Konstantinos, Lickert, Heiko, Feuchtinger, Annette, Tost, Monica, Coupland, Callum, Ständer, Lisa, Akindehin, Seun, Prakash, Sneha, Abrar, Faiyaz, Castelino, Russell L., He, Yantao, Knerr, Patrick J., Yang, Bin, Hogendorf, Wouter F. J., Zhang, Shiqi, Hofmann, Susanna M., Finan, Brian, DiMarchi, Richard D., Tschöp, Matthias H., Douros, Jonathan D., Müller, Timo D.

“…The development of single-molecule co-agonists for the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP)…”
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Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity by Grandl, Gerald, Collden, Gustav, Feng, Jin, Bhattacharya, Sreya, Klingelhuber, Felix, Schomann, Leopold, Bilekova, Sara, Ansarullah, Xu, Weiwei, Far, Fataneh Fathi, Tost, Monica, Gruber, Tim, Bastidas-Ponce, Aimée, Zhang, Qian, Novikoff, Aaron, Liskiewicz, Arkadiusz, Liskiewicz, Daniela, Garcia-Caceres, Cristina, Feuchtinger, Annette, Tschöp, Matthias H., Krahmer, Natalie, Lickert, Heiko, Müller, Timo D.

“…Insulin resistance is an early complication of diet-induced obesity (DIO) 1 , potentially leading to hyperglycaemia and hyperinsulinaemia, accompanied by…”
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GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice by Quarta, Carmelo, Stemmer, Kerstin, Novikoff, Aaron, Yang, Bin, Klingelhuber, Felix, Harger, Alex, Bakhti, Mostafa, Bastidas-Ponce, Aimee, Baugé, Eric, Campbell, Jonathan E., Capozzi, Megan, Clemmensen, Christoffer, Collden, Gustav, Cota, Perla, Douros, Jon, Drucker, Daniel J., DuBois, Barent, Feuchtinger, Annette, Garcia-Caceres, Cristina, Grandl, Gerald, Hennuyer, Nathalie, Herzig, Stephan, Hofmann, Susanna M., Knerr, Patrick J., Kulaj, Konxhe, Lalloyer, Fanny, Lickert, Heiko, Liskiewicz, Arek, Liskiewicz, Daniela, Maity, Gandhari, Perez-Tilve, Diego, Prakash, Sneha, Sanchez-Garrido, Miguel A., Zhang, Qian, Staels, Bart, Krahmer, Natalie, DiMarchi, Richard D., Tschöp, Matthias H., Finan, Brian, Müller, Timo D.

“…Dual agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPARɑ/ɣ) have beneficial effects on glucose and lipid metabolism in…”
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