Search Results - "Novershtern, Noa"

Deterministic direct reprogramming of somatic cells to pluripotency by Rais, Yoach, Zviran, Asaf, Geula, Shay, Gafni, Ohad, Chomsky, Elad, Viukov, Sergey, Mansour, Abed AlFatah, Caspi, Inbal, Krupalnik, Vladislav, Zerbib, Mirie, Maza, Itay, Mor, Nofar, Baran, Dror, Weinberger, Leehee, Jaitin, Diego A., Lara-Astiaso, David, Blecher-Gonen, Ronnie, Shipony, Zohar, Mukamel, Zohar, Hagai, Tzachi, Gilad, Shlomit, Amann-Zalcenstein, Daniela, Tanay, Amos, Amit, Ido, Novershtern, Noa, Hanna, Jacob H.

“…Somatic cells can be inefficiently and stochastically reprogrammed into induced pluripotent stem (iPS) cells by exogenous expression of Oct4 (also called…”
Get full text

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming by Mansour, Abed AlFatah, Gafni, Ohad, Weinberger, Leehee, Zviran, Asaf, Ayyash, Muneef, Rais, Yoach, Krupalnik, Vladislav, Zerbib, Mirie, Amann-Zalcenstein, Daniela, Maza, Itay, Geula, Shay, Viukov, Sergey, Holtzman, Liad, Pribluda, Ariel, Canaani, Eli, Horn-Saban, Shirley, Amit, Ido, Novershtern, Noa, Hanna, Jacob H.

“…The H3K27 demethylase Utx is reported to be a critical regulator for the initiation of somatic and germ cell reprogramming. Epigenetic stem-cell programming…”
Get full text

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis by Novershtern, Noa, Subramanian, Aravind, Lawton, Lee N., Mak, Raymond H., Haining, W. Nicholas, McConkey, Marie E., Habib, Naomi, Yosef, Nir, Chang, Cindy Y., Shay, Tal, Frampton, Garrett M., Drake, Adam C.B., Leskov, Ilya, Nilsson, Bjorn, Preffer, Fred, Dombkowski, David, Evans, John W., Liefeld, Ted, Smutko, John S., Chen, Jianzhu, Friedman, Nir, Young, Richard A., Golub, Todd R., Regev, Aviv, Ebert, Benjamin L.

“…Though many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis…”
Get full text

SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity by Sheban, Daoud, Shani, Tom, Maor, Roey, Aguilera-Castrejon, Alejandro, Mor, Nofar, Oldak, Bernardo, Shmueli, Merav D., Eisenberg-Lerner, Avital, Bayerl, Jonathan, Hebert, Jakob, Viukov, Sergey, Chen, Guoyun, Kacen, Assaf, Krupalnik, Vladislav, Chugaeva, Valeriya, Tarazi, Shadi, Rodríguez-delaRosa, Alejandra, Zerbib, Mirie, Ulman, Adi, Masarwi, Solaiman, Kupervaser, Meital, Levin, Yishai, Shema, Efrat, David, Yael, Novershtern, Noa, Hanna, Jacob H., Merbl, Yifat

“…The fidelity of the early embryonic program is underlined by tight regulation of the chromatin. Yet, how the chromatin is organized to prohibit the reversal of…”
Get full text

Context-dependent functional compensation between Ythdf m6A reader proteins by Lasman, Lior, Krupalnik, Vladislav, Viukov, Sergey, Mor, Nofar, Aguilera-Castrejon, Alejandro, Schneir, Dan, Bayerl, Jonathan, Mizrahi, Orel, Peles, Shani, Tawil, Shadi, Sathe, Shashank, Nachshon, Aharon, Shani, Tom, Zerbib, Mirie, Kilimnik, Itay, Aigner, Stefan, Shankar, Archana, Mueller, Jasmine R., Schwartz, Schraga, Stern-Ginossar, Noam, Yeo, Gene W., Geula, Shay, Novershtern, Noa, Hanna, Jacob H.

“…Here, Lasman et al. sought to understand the role of three homologous m 6 A-binding proteins (Ythdf1, Ythdf2, and Ythdf3) and systematically knocked out the…”
Get full text

Role of m6A in Embryonic Stem Cell Differentiation and in Gametogenesis by Lasman, Lior, Hanna, Jacob H, Novershtern, Noa

“…The rising field of RNA modifications is stimulating massive research nowadays. m6A, the most abundant mRNA modification is highly conserved during evolution…”
Get full text

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation by Geula, Shay, Moshitch-Moshkovitz, Sharon, Dominissini, Dan, Mansour, Abed AlFatah, Kol, Nitzan, Salmon-Divon, Mali, Hershkovitz, Vera, Peer, Eyal, Mor, Nofar, Manor, Yair S., Ben-Haim, Moshe Shay, Eyal, Eran, Yunger, Sharon, Pinto, Yishay, Jaitin, Diego Adhemar, Viukov, Sergey, Rais, Yoach, Krupalnik, Vladislav, Chomsky, Elad, Zerbib, Mirie, Maza, Itay, Rechavi, Yoav, Massarwa, Rada, Hanna, Suhair, Amit, Ido, Levanon, Erez Y., Amariglio, Ninette, Stern-Ginossar, Noam, Novershtern, Noa, Rechavi, Gideon, Hanna, Jacob H.

“…Naïve and primed pluripotent states retain distinct molecular properties, yet limited knowledge exists on how their state transitions are regulated. Here, we…”
Get full text

Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs by Tarazi, Shadi, Aguilera-Castrejon, Alejandro, Joubran, Carine, Ghanem, Nadir, Ashouokhi, Shahd, Roncato, Francesco, Wildschutz, Emilie, Haddad, Montaser, Oldak, Bernardo, Gomez-Cesar, Elidet, Livnat, Nir, Viukov, Sergey, Lokshtanov, Dmitry, Naveh-Tassa, Segev, Rose, Max, Hanna, Suhair, Raanan, Calanit, Brenner, Ori, Kedmi, Merav, Keren-Shaul, Hadas, Lapidot, Tsvee, Maza, Itay, Novershtern, Noa, Hanna, Jacob H.

“…In vitro cultured stem cells with distinct developmental capacities can contribute to embryonic or extraembryonic tissues after microinjection into…”
Get full text

Derivation of novel human ground state naive pluripotent stem cells by Gafni, Ohad, Weinberger, Leehee, Mansour, Abed AlFatah, Manor, Yair S., Chomsky, Elad, Ben-Yosef, Dalit, Kalma, Yael, Viukov, Sergey, Maza, Itay, Zviran, Asaf, Rais, Yoach, Shipony, Zohar, Mukamel, Zohar, Krupalnik, Vladislav, Zerbib, Mirie, Geula, Shay, Caspi, Inbal, Schneir, Dan, Shwartz, Tamar, Gilad, Shlomit, Amann-Zalcenstein, Daniela, Benjamin, Sima, Amit, Ido, Tanay, Amos, Massarwa, Rada, Novershtern, Noa, Hanna, Jacob H.

“…It is known that human embryonic stem (ES) cells are more similar to mouse primed epiblast stem cells than to naive mouse ES cells; here culture conditions are…”
Get full text

Dynamic stem cell states: naive to primed pluripotency in rodents and humans by Weinberger, Leehee, Ayyash, Muneef, Novershtern, Noa, Hanna, Jacob H.

“…Key Points Pluripotency is highly dynamic in vivo and evolves at different stages of pre- and post-implantation development. However, the feature of…”
Get full text

Principles of signaling pathway modulation for enhancing human naive pluripotency induction by Bayerl, Jonathan, Ayyash, Muneef, Shani, Tom, Manor, Yair Shlomo, Gafni, Ohad, Massarwa, Rada, Kalma, Yael, Aguilera-Castrejon, Alejandro, Zerbib, Mirie, Amir, Hadar, Sheban, Daoud, Geula, Shay, Mor, Nofar, Weinberger, Leehee, Naveh Tassa, Segev, Krupalnik, Vladislav, Oldak, Bernardo, Livnat, Nir, Tarazi, Shadi, Tawil, Shadi, Wildschutz, Emilie, Ashouokhi, Shahd, Lasman, Lior, Rotter, Varda, Hanna, Suhair, Ben-Yosef, Dalit, Novershtern, Noa, Viukov, Sergey, Hanna, Jacob H.

“…Isolating human MEK/ERK signaling-independent pluripotent stem cells (PSCs) with naive pluripotency characteristics while maintaining differentiation…”
Get full text

Physical Module Networks: an integrative approach for reconstructing transcription regulation by Novershtern, Noa, Regev, Aviv, Friedman, Nir

“…Motivation: Deciphering the complex mechanisms by which regulatory networks control gene expression remains a major challenge. While some studies infer…”
Get full text

Complete human day 14 post-implantation embryo models from naive ES cells by Oldak, Bernardo, Wildschutz, Emilie, Bondarenko, Vladyslav, Comar, Mehmet-Yunus, Zhao, Cheng, Aguilera-Castrejon, Alejandro, Tarazi, Shadi, Viukov, Sergey, Pham, Thi Xuan Ai, Ashouokhi, Shahd, Lokshtanov, Dmitry, Roncato, Francesco, Ariel, Eitan, Rose, Max, Livnat, Nir, Shani, Tom, Joubran, Carine, Cohen, Roni, Addadi, Yoseph, Chemla, Muriel, Kedmi, Merav, Keren-Shaul, Hadas, Pasque, Vincent, Petropoulos, Sophie, Lanner, Fredrik, Novershtern, Noa, Hanna, Jacob H.

“…The ability to study human post-implantation development remains limited owing to ethical and technical challenges associated with intrauterine development…”
Get full text

Medical Image Segmentation Using Directional Window Attention by Kareem, Daniya Najiha A., Fiaz, Mustansar, Novershtern, Noa, Cholakkal, Hisham

“…Accurate segmentation of medical images is crucial for diagnostic purposes, including cell segmentation, tumor identification, and organ localization…”
Get full text

Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors by Maza, Itay, Caspi, Inbal, Zviran, Asaf, Chomsky, Elad, Rais, Yoach, Viukov, Sergey, Geula, Shay, Buenrostro, Jason D, Weinberger, Leehee, Krupalnik, Vladislav, Hanna, Suhair, Zerbib, Mirie, Dutton, James R, Greenleaf, William J, Massarwa, Rada, Novershtern, Noa, Hanna, Jacob H

“…Methods for direct conversion of fibroblasts to other cell types using pluripotency-associated factors generate a transient pluripotent state. Somatic cells…”
Get full text

Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency by Mor, Nofar, Rais, Yoach, Sheban, Daoud, Peles, Shani, Aguilera-Castrejon, Alejandro, Zviran, Asaf, Elinger, Dalia, Viukov, Sergey, Geula, Shay, Krupalnik, Vladislav, Zerbib, Mirie, Chomsky, Elad, Lasman, Lior, Shani, Tom, Bayerl, Jonathan, Gafni, Ohad, Hanna, Suhair, Buenrostro, Jason D., Hagai, Tzachi, Masika, Hagit, Vainorius, Gintautas, Bergman, Yehudit, Greenleaf, William J., Esteban, Miguel A., Elling, Ulrich, Levin, Yishai, Massarwa, Rada, Merbl, Yifat, Novershtern, Noa, Hanna, Jacob H.

“…Mbd3, a member of nucleosome remodeling and deacetylase (NuRD) co-repressor complex, was previously identified as an inhibitor for deterministic induced…”
Get full text

Improving 3-D Medical Image Segmentation at Boundary Regions Using Local Self-Attention and Global Volume Mixing by Abdul Kareem, Daniya Najiha, Fiaz, Mustansar, Novershtern, Noa, Hanna, Jacob, Cholakkal, Hisham

“…Volumetric medical image segmentation is a fundamental problem in medical image analysis where the objective is to accurately classify a given 3-D volumetric…”
Get full text

Role of m 6 A in Embryonic Stem Cell Differentiation and in Gametogenesis by Lasman, Lior, Hanna, Jacob H, Novershtern, Noa

“…The rising field of RNA modifications is stimulating massive research nowadays. m A, the most abundant mRNA modification is highly conserved during evolution…”
Get full text

Role of [m.sup.6] A in Embryonic Stem Cell Differentiation and in Gametogenesis by Lasman, Lior, Hanna, Jacob H, Novershtern, Noa

“…The rising field of RNA modifications is stimulating massive research nowadays. [m.sup.6] A, the most abundant mRNA modification is highly conserved during…”
Get full text

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules by Zviran, Asaf, Mor, Nofar, Rais, Yoach, Gingold, Hila, Peles, Shani, Chomsky, Elad, Viukov, Sergey, Buenrostro, Jason D., Scognamiglio, Roberta, Weinberger, Leehee, Manor, Yair S., Krupalnik, Vladislav, Zerbib, Mirie, Hezroni, Hadas, Jaitin, Diego Adhemar, Larastiaso, David, Gilad, Shlomit, Benjamin, Sima, Gafni, Ohad, Mousa, Awni, Ayyash, Muneef, Sheban, Daoud, Bayerl, Jonathan, Aguilera-Castrejon, Alejandro, Massarwa, Rada, Maza, Itay, Hanna, Suhair, Stelzer, Yonatan, Ulitsky, Igor, Greenleaf, William J., Tanay, Amos, Trumpp, Andreas, Amit, Ido, Pilpel, Yitzhak, Novershtern, Noa, Hanna, Jacob H.

“…The epigenetic dynamics of induced pluripotent stem cell (iPSC) reprogramming in correctly reprogrammed cells at high resolution and throughout the entire…”
Get full text