Search Results - "Noveck, Robert J"

Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban by Ansell, Jack E, Bakhru, Sasha H, Laulicht, Bryan E, Steiner, Solomon S, Grosso, Michael, Brown, Karen, Dishy, Victor, Noveck, Robert J, Costin, James C

“…Among 80 healthy persons who had received a single dose of edoxaban, the whole-blood clotting time was reduced significantly more rapidly in those who received…”
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Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban by Ansell, Jack E, Bakhru, Sasha H, Laulicht, Bryan E, Steiner, Solomon S, Grosso, Michael A, Brown, Karen, Dishy, Victor, Lanz, Hans J, Mercuri, Michele F, Noveck, Robert J, Costin, James C

“…Of the new direct oral anticoagulants, direct factor Xa inhibitors are limited by the absence of a proven reversal agent. We assessed the safety, tolerability…”
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Proposed Strategies for the Integration of Genomics in Primary Care by Oo, Charles, PharmD, PhD, Noveck, Robert J., MD, PhD

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Intraarterial Microdosing: A Novel Drug Development Approach, Proof-of-Concept PET Study in Rats by Burt, Tal, Rouse, Douglas C, Lee, Kihak, Wu, Huali, Layton, Anita T, Hawk, Thomas C, Weitzel, Douglas H, Chin, Bennett B, Cohen-Wolkowiez, Michael, Chow, Shein-Chung, Noveck, Robert J

“…Intraarterial microdosing (IAM) is a novel drug development approach combining intraarterial drug delivery and microdosing. We aimed to demonstrate that IAM…”
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A randomized trial of the safety, pharmacokinetics and pharmacodynamics of edoxaban, an oral factor Xa inhibitor, following a switch from warfarin by Mendell, Jeanne, Noveck, Robert J., Shi, Minggao

“…Aims To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of edoxaban, an oral direct factor Xa inhibitor, in healthy subjects switching…”
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Pharmacokinetics, pharmacodynamics, and safety of cinacalcet hydrochloride in hemodialysis patients at doses up to 200 mg once daily by Harris, Robert Z., Padhi, Desmond, Marbury, Thomas C., Noveck, Robert J., Salfi, Margaret, Sullivan, John T.

“…Background: Cinacalcet hydrochloride (HCl) can be used to manage the secondary hyperparathyroidism of patients with chronic kidney disease. This study…”
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Controlled Phase III Clinical Trial of Diclofenac Potassium Liquid-Filled Soft Gelatin Capsule for Treatment of Postoperative Dental Pain by Zuniga, John R., DMD, PhD, Malmström, Hans, DDS, Noveck, Robert J., MD, PhD, Campbell, John H., DDS, MS, Christensen, Steven, DDS, Glickman, Robert S., DMD, Tomasetti, Boyd J., DMD, Boesing, Stephen E., MS

“…Purpose The purpose of the present study was to assess the safety and efficacy of oral diclofenac potassium liquid-filled soft gelatin capsule (DPSGC) that…”
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Pharmacokinetics of the direct factor Xa inhibitor edoxaban and digoxin administered alone and in combination by Mendell, Jeanne, Noveck, Robert J, Shi, Minggao

“…The oral anticoagulant edoxaban, a factor Xa inhibitor, will likely be coadministered with digoxin in some patients with atrial fibrillation. Both drugs are…”
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A Phase 1 Randomized Study of Single Intravenous Infusions of the Novel Nitroxyl Donor BMS‐986231 in Healthy Volunteers by Cowart, Douglas, Venuti, Robert P., Lynch, Kim, Guptill, Jeffrey T., Noveck, Robert J., Foo, Shi Yin

“…Nitroxyl (HNO) is a reactive nitrogen molecule that has potential therapeutic benefits for patients with acute heart failure. The results of the first‐in‐human…”
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Pharmacokinetics of the Direct Factor Xa Inhibitor Edoxaban and Digoxin Administered Alone and in Combination by Mendell, Jeanne, Noveck, Robert J, Shi, Minggao

“…The oral anticoagulant edoxaban, a factor Xa inhibitor, will likely be coadministered with digoxin in some patients with atrial fibrillation. Both drugs are…”
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Reversibility of peripheral blood leukocyte phenotypic and functional changes after exposure to and withdrawal from tofacitinib, a Janus kinase inhibitor, in healthy volunteers by Weinhold, Kent J., Bukowski, Jack F., Brennan, Todd V., Noveck, Robert J., Staats, Janet S., Lin, Liwen, Stempora, Linda, Hammond, Constance, Wouters, Ann, Mojcik, Christopher F., Cheng, John, Collinge, Mark, Jesson, Michael I., Hazra, Anasuya, Biswas, Pinaki, Lan, Shuping, Clark, James D., Hodge, Jennifer A.

“…This study evaluated the short-term effects of tofacitinib treatment on peripheral blood leukocyte phenotype and function, and the reversibility of any such…”
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Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia by Schroeder, Thies, Piantadosi, Claude A., Natoli, Michael J., Autmizguine, Julie, Cohen‐Wolkowieczs, Michael, Hamilton, Karyn L., Bell, Christopher, Klawitter, Jelena, Christians, Uwe, Irwin, David C., Noveck, Robert J.

“…We hypothesized that concomitant pharmacological inhibition of the endothelin and adenosine pathway is safe and improves exercise performance in hypoxic…”
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Low Plasma Gelsolin Concentrations in Chronic Granulomatous Disease by Audley, John, Gliniewicz, Emily F., Zarember, Kol A., Hong, Hanna S., Wald, Gal, Kuhns, Douglas B., Kang, Elizabeth, Malech, Harry L., Suffredini, Anthony F., Noveck, Robert J., Dinubile, Mark J., Levinson, Susan L., Stossel, Thomas P., Gallin, John I.

“…Plasma gelsolin (pGSN) is the secreted isoform of an intracellular actin remodeling protein found in high concentrations in human plasma. Clinical studies…”
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First‐in‐Human Studies of MW01‐6‐189WH, a Brain‐Penetrant, Antineuroinflammatory Small‐Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers by Van Eldik, Linda J., Sawaki, Lumy, Bowen, Karen, Laskowitz, Daniel T., Noveck, Robert J., Hauser, Byron, Jordan, Lynn, Spears, Tracy G., Wu, Huali, Watt, Kevin, Raja, Shruti, Roy, Saktimayee M., Watterson, D. Martin, Guptill, Jeffrey T.

“…MW01‐6‐189WH (MW189) is a novel central nervous system–penetrant small‐molecule drug candidate that selectively attenuates stressor‐induced proinflammatory…”
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The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans by Strand, Trond-Eirik, Khiabani, Hasse Z, Boico, Alina, Radiloff, Daniel, Zhao, Yulin, Hamilton, Karyn L, Christians, Uwe, Klawitter, Jelena, Noveck, Robert J, Piantadosi, Claude A, Bell, Christopher, Irwin, David, Schroeder, Thies

“…Hypoxemia can be life-threatening, both acutely and chronically. Because hypoxemia causes vascular dysregulation that further restricts oxygen availability to…”
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Pharmacological Modulation of Peripheral T and B Lymphocytes by a Selective Sphingosine 1-Phosphate Receptor-1 Modulator by Moberly, James B., Rohatagi, Shashank, Zahir, Hamim, Hsu, Ching, Noveck, Robert J., Truitt, Kenneth E.

“…CS-0777 is a selective sphingosine 1-phosphate receptor-1 (S1P1) modulator under development for treatment of autoimmune conditions. A randomized,…”
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Effect of Ketoconazole on the Pharmacokinetic Profile of Buprenorphine following Administration of a Once-Weekly Buprenorphine Transdermal System by Kapil, Ram P., Cipriano, Alessandra, Michels, Gregory H., Perrino, Peter, OʼKeefe, Sarah A., Shet, Manjunath S., Colucci, Salvatore V., Noveck, Robert J., Harris, Stephen C.

“…Background and Objective: Buprenorphine is extensively metabolized by cytochrome P450 (CYP) 3A4. This study evaluated the effect of ketoconazole, a CYP3A4…”
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Onset of action of diclofenac potassium liquid-filled capsules in dental surgery patients by Zuniga, John R., Noveck, Robert J., Schmidt, William K., Boesing, Stephen E., Hersh, Elliot V.

“…Abstract Objective: Diclofenac potassium soft gelatin capsules (DPSGC) are a low-dose, liquid-filled formulation that uses patented dispersion technology to…”
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Effect of Ketoconazole on the Pharmacokinetic Profile of Buprenorphine following Administration of a Once-Weekly Buprenorphine Transdermal System by Kapil, Ram P., Cipriano, Alessandra, Michels, Gregory H., Perrino, Peter, O’Keefe, Sarah A., Shet, Manjunath S., Colucci, Salvatore V., Noveck, Robert J., Harris, Stephen C.

“…Background and Objective: Buprenorphine is extensively metabolized by cytochrome P450 (CYP) 3A4. This study evaluated the effect of ketoconazole, a CYP3A4…”
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Effect of the Bile Acid Sequestrant Colesevelam on the Pharmacokinetics of Pioglitazone, Repaglinide, Estrogen Estradiol, Norethindrone, Levothyroxine, and Glyburide by Brown, Karen S., Armstrong, Ingrid C., Wang, Antonia, Walker, Joseph R., Noveck, Robert J., Swearingen, Dennis, Allison, Mark, Kissling, James C., Kisicki, James, Salazar, Daniel E.

“…The purpose of this study was to assess effects of colesevelam on the pharmacokinetics of glyburide, levothyroxine, estrogen estradiol (EE), norethindrone…”
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