Search Results - "Nourshargh, S."

Role of neutrophil elastase in LTB 4 ‐induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice by Young, R E, Voisin, M‐B, Wang, S, Dangerfield, J, Nourshargh, S

“…Background and purpose: The serine protease neutrophil elastase (NE) appears to regulate inflammatory responses at multiple levels but its role in leukocyte…”
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Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo by Tharp, William G., Yadav, R., Irimia, D., Upadhyaya, A., Samadani, A., Hurtado, O., Liu, S‐Y., Munisamy, S., Brainard, D. M., Mahon, M. J., Nourshargh, S., Oudenaarden, A., Toner, M. G., Poznansky, Mark C.

“…We report for the first time that primary human neutrophils can undergo persistent, directionally biased movement away from a chemokine in vitro and in vivo,…”
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The melanocortin MC 1 receptor agonist BMS‐470539 inhibits leucocyte trafficking in the inflamed vasculature by Leoni, G, Voisin, M‐B, Carlson, K, Getting, SJ, Nourshargh, S, Perretti, M

“…Background and purpose:  Over three decades of research evaluating the biology of melanocortin (MC) hormones and synthetic peptides, activation of the MC type…”
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The melanocortin MC1 receptor agonist BMS‐470539 inhibits leucocyte trafficking in the inflamed vasculature by Leoni, G, Voisin, M‐B, Carlson, K, Getting, SJ, Nourshargh, S, Perretti, M

“…Background and purpose:  Over three decades of research evaluating the biology of melanocortin (MC) hormones and synthetic peptides, activation of the MC type…”
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Role of neutrophil elastase in LTB4‐induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice by Young, R E, Voisin, M‐B, Wang, S, Dangerfield, J, Nourshargh, S

“…Background and purpose: The serine protease neutrophil elastase (NE) appears to regulate inflammatory responses at multiple levels but its role in leukocyte…”
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An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane by Wakelin, M W, Sanz, M J, Dewar, A, Albelda, S M, Larkin, S W, Boughton-Smith, N, Williams, T J, Nourshargh, S

“…Platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) plays an active role in the process of leukocyte migration through cultured endothelial cells in…”
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A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo by WEG, V. B, WILLIAMS, T. J, LOBB, R. R, NOURSHARGH, S

“…Using an in vivo test system, the role of the beta 1 integrin very late activation antigen-4 (VLA-4) in eosinophil accumulation in allergic and nonallergic…”
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Divergent mechanisms of action of the inflammatory cytokines interleukin 1‐β and tumour necrosis factor‐α in mouse cremasteric venules by Young, R E, Thompson, R D, Nourshargh, S

“…Protein synthesis dependency and the role of endogenously generated platelet activating factor (PAF) and leukotriene B4 (LTB4) in leukocyte migration through…”
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MRL/lpr lupus‐prone mice show exaggerated ICAM‐1‐dependent leucocyte adhesion and transendothelial migration in response to TNF‐α by Marshall, D., Dangerfield, J. P., Bhatia, V. K., Larbi, K. Y., Nourshargh, S., Haskard, D. O.

“…Objective. Endothelial activation and dysfunctional leucocyte–endothelial interactions are thought to play key roles in the pathogenesis of systemic lupus…”
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Intravital microscopy in the study of ANCA-associated systemic vasculitis by Little, M A, Pusey, C D, Nourshargh, S

“…In addition to being useful clinical markers of systemic vasculitis, anti-neutrophil cytoplasm antibodies (ANCA) may play a role in the initiation of…”
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Lung eosinophilia is dependent on IL-5 and the adhesion molecules CD18 and VLA-4, in a guinea-pig model by Das, A M, Williams, T J, Lobb, R, Nourshargh, S

“…Blood and tissue-eosinophilia is a characteristic feature of a number of disease states. In experimental animals, the intravenous injection of parasitic larvae…”
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VCAM-1 has a tissue-specific role in mediating interleukin-4–induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration by Larbi, Karen Y., Allen, Andrew R., Tam, Frederick W.K., Haskard, Dorian O., Lobb, Roy R., Silva, Patricia M.R., Nourshargh, Sussan

“…Eosinophil accumulation has been associated with the pathogenesis of numerous allergic inflammatory disorders. Despite the great interest in this response,…”
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Human eotaxin induces eosinophil extravasation through rat mesenteric venules: role of α4 integrins and vascular cell adhesion molecule‐1 by Nagai, K, Larkin, S, Hartnell, A, Larbi, K, Razi Aghakhani, M, Windley, C, Davies, D, Lobb, R R, Williams, T J, Nourshargh, S

“…Eotaxin is a potent eosinophil‐specific CC‐chemokine, which has been shown to play a role in the selective induction of eosinophil accumulation in a number of…”
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The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues by Nourshargh, Sussan, Krombach, Fritz, Dejana, Elisabetta

“…Innate and adaptive immunological responses are accompanied by leukocyte adhesion to the blood‐vessel wall and their subsequent infiltration into the…”
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IL-1 is a potent inducer of eosinophil accumulation in rat skin. Inhibition of response by a platelet-activating factor antagonist and an anti-human IL-8 antibody by Sanz, MJ, Weg, VB, Bolanowski, MA, Nourshargh, S

“…The aim of the present study was to investigate directly and characterize the ability of IL-1 beta in inducing eosinophil accumulation in vivo. For this…”
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Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo by Little, Mark A., Smyth, C. Lucy, Yadav, Rashmi, Ambrose, Lyn, Cook, H. Terence, Nourshargh, Sussan, Pusey, Charles D.

“…Systemic small vessel vasculitis is associated with antineutrophil cytoplasm antibodies (ANCAs). While there is mounting in vitro evidence to suggest that…”
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Experimental Autoimmune Vasculitis: An Animal Model of Anti-neutrophil Cytoplasmic Autoantibody-Associated Systemic Vasculitis by Little, Mark A, Smyth, Lucy, Salama, Alan D, Mukherjee, Sriparna, Smith, Jennifer, Haskard, Dorian, Nourshargh, Sussan, Cook, H. Terence, Pusey, Charles D

“…The morbidity burden associated with anti-neutrophil cytoplasmic autoantibody-associated vasculitis is increasing, and many novel biological therapies are now…”
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Transmigration through venular walls: a key regulator of leukocyte phenotype and function by Nourshargh, Sussan, Marelli-Berg, Federica M.

“…Leukocyte transmigration is a key event in host defense. As well as delivering leukocytes to sites of inflammation, this response also has an important role in…”
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VCAM‐1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM‐1 in rat skin by Davies, D, Larbi, K, Allen, A, Sanz, M, Weg, V B, Haskard, D O, Lobb, R R, Nourshargh, S

“…The aim of the present study was to investigate the role of the adhesion pathway α4 integrins/vascular cell adhesion molecule type 1 (VCAM‐1) in rapid…”
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Effect of aprotinin (trasylol) on the inflammatory and thrombotic complications of conventional cardiopulmonary bypass surgery by Landis, R C, Asimakopoulos, G, Poullis, M, Thompson, R, Nourshargh, S, Haskard, D O, Taylor, K M

“…Before the discovery of its hemostatic properties, aprotinin was thought of as a potential anti-inflammatory agent. Its clinical introduction in 1987 to…”
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