Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents

Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents

Despite the growing interest by researchers into cellular senescence, a hallmark of cellular aging, its role in human skin remains equivocal. The skin is the largest and most accessible human organ, reacting to the external and internal environment. Hence, it is an organ of choice to investigate cel...

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Bibliographic Details
Published in:Aging cell Vol. 22; no. 6; pp. e13845 - n/a
Main Authors: Dańczak‐Pazdrowska, Aleksandra, Gornowicz‐Porowska, Justyna, Polańska, Adriana, Krajka‐Kuźniak, Violetta, Stawny, Maciej, Gostyńska, Aleksandra, Rubiś, Błażej, Nourredine, Sarah, Ashiqueali, Sarah, Schneider, Augusto, Tchkonia, Tamara, Wyles, Saranya P., Kirkland, James L., Masternak, Michal M.
Format: Journal Article
Language:English
Published: England John Wiley & Sons, Inc 01-06-2023
John Wiley and Sons Inc
Subjects:
Aging
Cell cycle
cellular senescence
Cellular Senescence - physiology
Extracellular matrix
Fibroblasts
Genotype & phenotype
Humans
Insulin-like growth factors
Kinases
Molecular modelling
Physiology
Radiation
Review
Senescence
senescence‐related skin disorders
senolytic agents
senomorphic agents
Signal Transduction
Skin
Skin Aging
Skin diseases
Wound healing
senescence-related skin disorders
skin aging
cellular senescence
senolytic agents
senomorphic agents
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Summary:Despite the growing interest by researchers into cellular senescence, a hallmark of cellular aging, its role in human skin remains equivocal. The skin is the largest and most accessible human organ, reacting to the external and internal environment. Hence, it is an organ of choice to investigate cellular senescence and to target root‐cause aging processes using senolytic and senomorphic agents, including naturally occurring plant‐based derivatives. This review presents different aspects of skin cellular senescence, from physiology to pathology and signaling pathways. Cellular senescence can have both beneficial and detrimental effects on the skin, indicating that both prosenescent and antisenescent therapies may be desirable, based on the context. Knowledge of molecular mechanisms involved in skin cellular senescence may provide meaningful insights for developing effective therapeutics for senescence‐related skin disorders, such as wound healing and cosmetic skin aging changes. Aging and external stressors including exposure to UV light promote senescence of keratinocytes accelerating aging process. Development of effective plant‐based senotherapeutics represent novel approaches for senescent‐related skin disorders and can be used in cosmetic skin changes related to aging.
Bibliography:Aleksandra Dańczak‐Pazdrowska and Justyna Gornowicz‐Porowska: Shared cofirst authorship.
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-2
ISSN:1474-9718
1474-9726
DOI:10.1111/acel.13845