Search Results - "Notley, C"

Lest we forget. Illuminating lived experience of the Covid-19 pandemic and lockdown by Hanson, S, Belderson, P, Ward, E, Naughton, F, Notley, C

“…The COVID-19 pandemic and associated 'lockdowns' profoundly impacted people's lives in 2020-2021 and beyond. This study sought to understand unique…”
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Medicalisation of vaping in the UK? E-cigarette users’ perspectives on the merging of commercial and medical routes to vaping by Ward, E, Dawkins, L, Holland, R, Pope, I, Notley, C

“…Background: In the UK, most smokers choosing e-cigarettes to quit smoking will access vaping via commercial routes. In recent years, however, a shift towards…”
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The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study by James, P. D., Notley, C., Hegadorn, C., Leggo, J., Tuttle, A., Tinlin, S., Brown, C., Andrews, C., Labelle, A., Chirinian, Y., O'Brien, L., Othman, M., Rivard, G., Rapson, D., Hough, C., Lillicrap, D.

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The genetics of Canadian type 3 von Willebrand disease: further evidence for co‐dominant inheritance of mutant alleles by Bowman, M., Tuttle, A., Notley, C., Brown, C., Tinlin, S., Deforest, M., Leggo, J., Blanchette, V.S., Lillicrap, D., James, P.

“…Summary Background Type 3 von Willebrand disease (VWD) is the most severe form of the disease and is classically inherited in an autosomal recessive fashion…”
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Abnormal von Willebrand factor secretion, factor VIII stabilization and thrombus dynamics in type 2N von Willebrand disease mice by Swystun, L. L., Georgescu, I., Mewburn, J., Deforest, M., Nesbitt, K., Hebert, K., Dwyer, C., Brown, C., Notley, C., Lillicrap, D.

“…Essentials Type 2N von Willebrand disease involves impaired von Willebrand factor to factor VIII binding. Type 2N von Willebrand disease mutations exhibit…”
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Chronic rhinosinusitis: patient experiences of primary and secondary care - a qualitative study by Erskine, S.E., Verkerk, M.M., Notley, C., Williamson, I.G., Philpott, C.M.

“…Objectives To explore the experience of CRS and its management from the perspective of patients with CRS. To our knowledge, this is the first qualitative study…”
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Genetic linkage and association analysis in type 1 von Willebrand disease: results from the Canadian Type 1 VWD Study by JAMES, P. D., PATERSON, A. D., NOTLEY, C., CAMERON, C., HEGADORN, C., TINLIN, S., BROWN, C., O'BRIEN, L., LEGGO, J., LILLICRAP, D.

“…Background: von Willebrand disease (VWD) is the most common bleeding disorder known in humans, with type 1 VWD representing the majority of cases. Unlike the…”
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The experience of long-term opiate maintenance treatment and reported barriers to recovery: a qualitative systematic review by Notley, Caitlin, Blyth, Annie, Maskrey, Vivienne, Craig, Jean, Holland, Richard

“…To inform understanding of the experience of long-term opiate maintenance and identify barriers to recovery. A qualitative systematic review. 14 studies in 17…”
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Influence of a GT repeat element on shear stress responsiveness of the VWF gene promoter by HOUGH, C., CAMERON, C. L., NOTLEY, C. R. P., BROWN, C., O’BRIEN, L., KEIGHTLEY, A. M., BERBER, E., LILLICRAP, D.

“…Background: Plasma von Willebrand factor (VWF) is mainly derived from endothelial cells, cells that express a large repertoire of genes that are…”
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Challenges in defining type 2M von Willebrand disease: results from a Canadian cohort study by JAMES, P. D., NOTLEY, C., HEGADORN, C., POON, M.‐C., WALKER, I., RAPSON, D., LILLICRAP, D.

“…Background/methods: In order to better characterize the genotype–phenotype correlation in type 2M von Willebrand disease (VWD), we sequenced the coding region…”
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The effect of exercise on von Willebrand factor and ADAMTS‐13 in individuals with type 1 and type 2B von Willebrand disease by STAKIW, J., BOWMAN, M., HEGADORN, C., PRUSS, C., NOTLEY, C., GROOT, E., LENTING, P. J., RAPSON, D., LILLICRAP, D., JAMES, P.

“…Background: The effect of exercise on von Willebrand factor (VWF) and ADAMTS‐13 levels in individuals with von Willebrand disease (VWD) has never been…”
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Expanded phenotype–genotype correlations in a pediatric population with type 1 von Willebrand disease by ROBERTSON, J. D., YENSON, P. R., RAND, M. L., BLANCHETTE, V. S., CARCAO, M. D., NOTLEY, C., LILLICRAP, D., JAMES, P. D.

“…Background: Recent phenotype–genotype studies have provided valuable insights into the pathophysiology of type 1 von Willebrand disease (VWD); however, no…”
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Role of the Liver-Enriched Transcription Factor Hepatocyte Nuclear Factor 1 in Transcriptional Regulation of the Factor VIII Gene by Mcglynn, L. K., Mueller, C. R., Begbie, M., Notley, C. R., Lillicrap, D.

“…Coagulation factor VIII is an essential cofactor required for normal hemostatic function. A deficiency in factor VIII results in the bleeding disorder…”
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PB0815 Involvement of the Nuclear Protein, TC2N, in Regulating VWF Levels in Endothelial Cells by Notley, C., Bowman, M., James, P., Lillicrap, D.

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The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF‐dependent and independent manner by Swystun, Laura L., Notley, Colleen, Georgescu, Ilinca, Lai, Jesse D., Nesbitt, Kate, James, Paula D., Lillicrap, David

“…Essentials CLEC4M is an endocytic receptor for factor FVIII. CLEC4M interacts with FVIII in a VWF‐dependent and independent manner. CLEC4M binds to…”
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The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen by Swystun, Laura L., Ogiwara, Kenichi, Lai, Jesse D., Ojala, Juha R. M., Rawley, Orla, Lassalle, Fanny, Notley, Colleen, Rengby, Olle, Michels, Alison, Nesbitt, Kate, Tryggvason, Karl, Lillicrap, David

“…Background Scavenger receptors play a significant role in clearing aged proteins from the plasma, including the large glycoprotein coagulation factors von…”
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Perception of need and barriers to access: the mental health needs of young people attending a Youth Offending Team in the UK by Walsh, Judi, Scaife, Victoria, Notley, Caitlin, Dodsworth, Jane, Schofield, Gillian

“…This study used a mixed methodology with young offenders attending a Youth Offending Service to identify, with regard to mental health problems, perceptions of…”
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Identification and functional characterization of a novel 27-bp deletion in the macroglycopeptide-coding region of the GPIBA gene resulting in platelet-type von Willebrand disease by Othman, Maha, Notley, Colleen, Lavender, Frances Louise, White, Helen, Byrne, Christopher D., Lillicrap, David, O'Shaughnessy, Denise Frances

“…Interaction between the platelet glycoprotein Ibα (GPIbα) receptor and its adhesive ligand von Willebrand factor (VWF) has a critical role in the process of…”
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Four groups of illicit substance users amongst the adult 'hidden' non-problematic community by Notley, Caitlin

“…This paper describes and distinguishes between adult drug users' perceptions of their own drug use. Focusing on 'non-problematic' (non-addicted) users over the…”
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Scavenger receptor class A member 5 (SCARA5) binds and internalizes VWF in vitro : a novel candidate VWF clearance receptor by Ogiwara, K, Swystun, L, Brown, C, Notley, C, Ojala, J, Tryggvason, K, Lillicrap, D

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