Search Results - "Noshi, Takeshi"

Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts by Ikematsu, Hideyuki, Hayden, Frederick G, Kawaguchi, Keiko, Kinoshita, Masahiro, de Jong, Menno D, Lee, Nelson, Takashima, Satoru, Noshi, Takeshi, Tsuchiya, Kenji, Uehara, Takeki

“…In a randomized, double-blind trial that treated household contacts of patients with influenza with a single dose of baloxavir or placebo, participants taking…”
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In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit by Noshi, Takeshi, Kitano, Mitsutaka, Taniguchi, Keiichi, Yamamoto, Atsuko, Omoto, Shinya, Baba, Keiko, Hashimoto, Takashi, Ishida, Kayo, Kushima, Yukihiro, Hattori, Kazunari, Kawai, Makoto, Yoshida, Ryu, Kobayashi, Masanori, Yoshinaga, Tomokazu, Sato, Akihiko, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi, Shishido, Takao, Naito, Akira

“…Cap-dependent endonuclease (CEN) resides in the PA subunit of the influenza virus and mediates the critical “cap-snatching” step of viral RNA transcription,…”
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Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models by Fukao, Keita, Ando, Yoshinori, Noshi, Takeshi, Kitano, Mitsutaka, Noda, Takahiro, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira

“…Baloxavir marboxil (BXM) is an orally available small molecule inhibitor of cap-dependent endonuclease (CEN), an essential enzyme in the initiation of mRNA…”
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Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil by Taniguchi, Keiichi, Ando, Yoshinori, Nobori, Haruaki, Toba, Shinsuke, Noshi, Takeshi, Kobayashi, Masanori, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira, Matsuno, Keita, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi

“…Human infections with avian-origin influenza A(H7N9) virus represent a serious threat to global health; however, treatment options are limited. Here, we show…”
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Pharmacokinetic and pharmacodynamic analysis of baloxavir marboxil, a novel cap-dependent endonuclease inhibitor, in a murine model of influenza virus infection by Ando, Yoshinori, Noshi, Takeshi, Sato, Kenji, Ishibashi, Toru, Yoshida, Yuki, Hasegawa, Takahiro, Onishi, Motoyasu, Kitano, Mitsutaka, Oka, Ryoko, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira

“…Baloxavir acid, the active form of the orally available prodrug baloxavir marboxil, is a novel cap-dependent endonuclease inhibitor of influenza virus…”
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Prophylactic Treatment with Baloxavir Protects Mice from Lethal Infection with Influenza A and B Viruses by Fukao, Keita, Noshi, Takeshi, Shano, Shinya, Baba, Kaoru, Sato, Kenji, Sakuramoto, Masashi, Kitade, Naohisa, Tanioka, Hideki, Kusakabe, Shinji, Shishido, Takao

“…Influenza remains a worldwide health concern. Antiviral drugs are considered as one of the useful options for its prevention as a complementary measure to…”
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In Vivo Antiviral Activity of Baloxavir against PA/I38T-Substituted Influenza A Viruses at Clinically Relevant Doses by Kuroda, Takayuki, Fukao, Keita, Yoshida, Shinpei, Oka, Ryoko, Baba, Kaoru, Ando, Yoshinori, Taniguchi, Keiichi, Noshi, Takeshi, Shishido, Takao

“…Although the prevalence of polymerase acidic (PA)/I38T strains of influenza virus with reduced susceptibility to baloxavir acid is low, there is a possibility…”
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Open-label study of the safety, pharmacokinetics, and effectiveness of a 2 mg/kg dose of baloxavir marboxil 2% granules in children <20 kg with influenza by Sonoyama, Takuhiro, Sakaguchi, Hiroki, Koshimichi, Hiroki, Noshi, Takeshi, Tsuchiya, Kenji, Uehara, Takeki

“…Baloxavir marboxil is an oral anti-influenza drug with demonstrated safety and efficacy in pediatric patients when a 2% granules formulation is administered at…”
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Characterization of the In Vitro and In Vivo Efficacy of Baloxavir Marboxil against H5 Highly Pathogenic Avian Influenza Virus Infection by Taniguchi, Keiichi, Ando, Yoshinori, Kobayashi, Masanori, Toba, Shinsuke, Nobori, Haruaki, Sanaki, Takao, Noshi, Takeshi, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira, Matsuno, Keita, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi

“…Human infections caused by the H5 highly pathogenic avian influenza virus (HPAIV) sporadically threaten public health. The susceptibility of HPAIVs to…”
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Antiviral activity of stachyflin on influenza A viruses of different hemagglutinin subtypes by Motohashi, Yurie, Igarashi, Manabu, Okamatsu, Masatoshi, Noshi, Takeshi, Sakoda, Yoshihiro, Yamamoto, Naoki, Ito, Kimihito, Yoshida, Ryu, Kida, Hiroshi

“…BACKGROUND: The hemagglutinin (HA) of influenza viruses is a possible target for antiviral drugs because of its key roles in the initiation of infection…”
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The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral by GARVEY, Edward P, JOHNS, Brian A, WEATHERHEAD, Jason G, KOBLE, Cecilia S, ALIEN, Scott H, SCHALLER, Lee T, SHERRILL, Ronald G, YOSHINAGA, Tomokazu, KOBAYASHI, Masanori, WAKASA-MORIMOTO, Chiaki, MIKI, Shigeru, NAKAHARA, Koichiro, GARTLAND, Margaret J, NOSHI, Takeshi, SATO, Akihiko, FUJIWARA, Tamio, FOSTER, Scott A, MILLER, Wayne H, FERRIS, Robert G, HAZEN, Richard J, UNDERWOOD, Mark R, BOROS, Eric E, THOMPSON, James B

“…ERRATUM ( vol. 52 , p. 1899 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
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A Strategy for Neuraminidase Inhibitors Using Mechanism-Based Labeling Information by Hinou, Hiroshi, Miyoshi, Risho, Takasu, Yasuaki, Kai, Hirokazu, Kurogochi, Masaki, Arioka, Shingo, Gao, Xiao-Dong, Miura, Nobuaki, Fujitani, Naoki, Omoto, Shinya, Yoshinaga, Tomokazu, Fujiwara, Tamio, Noshi, Takeshi, Togame, Hiroko, Takemoto, Hiroshi, Nishimura, Shin-Ichiro

“…A potent inhibitor for Vibrio cholerae neuraminidase (VCNA) was developed by using a novel two‐step strategy, a target amino acid validation using…”
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Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil by Omoto, Shinya, Speranzini, Valentina, Hashimoto, Takashi, Noshi, Takeshi, Yamaguchi, Hiroto, Kawai, Makoto, Kawaguchi, Keiko, Uehara, Takeki, Shishido, Takao, Naito, Akira, Cusack, Stephen

“…Baloxavir acid (BXA), derived from the prodrug baloxavir marboxil (BXM), potently and selectively inhibits the cap-dependent endonuclease within the polymerase…”
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Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection by Fukao, Keita, Noshi, Takeshi, Yamamoto, Atsuko, Kitano, Mitsutaka, Ando, Yoshinori, Noda, Takahiro, Baba, Kaoru, Matsumoto, Kazumi, Higuchi, Naoko, Ikeda, Minoru, Shishido, Takao, Naito, Akira

“…Abstract Objectives Baloxavir marboxil (formerly S-033188) is a first-in-class, orally available, cap-dependent endonuclease inhibitor licensed in Japan and…”
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Effects of Mutation in Hepatitis C Virus Nonstructural Protein 5A on Interferon Resistance Mediated by Inhibition of PKR Kinase Activity in Mammalian Cells by Noguchi, Tohru, Satoh, Shinya, Noshi, Takeshi, Hatada, Eriko, Fukuda, Ryuji, Kawai, Akihiko, Ikeda, Satoru, Hijikata, Makoto, Shimotohno, Kunitada

“…The IFN‐induced double‐stranded RNA (dsRNA)‐activated protein kinase PKR is one of the key molecules in the antiviral effects of IFN. To clarify the effects of…”
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Dihydrodibenzothiepine: Promising hydrophobic pharmacophore in the influenza cap-dependent endonuclease inhibitor by Taoda, Yoshiyuki, Miyagawa, Masayoshi, Akiyama, Toshiyuki, Tomita, Kenji, Hasegawa, Yasushi, Yoshida, Ryu, Noshi, Takeshi, Shishido, Takao, Kawai, Makoto

“…[Display omitted] This work describes a set of discovery research studies of an influenza cap-dependent endonuclease (CEN) inhibitor with a carbamoyl pyridone…”
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The impact of PA/I38 substitutions and PA polymorphisms on the susceptibility of zoonotic influenza A viruses to baloxavir by Taniguchi, Keiichi, Noshi, Takeshi, Omoto, Shinya, Sato, Akihiko, Shishido, Takao, Matsuno, Keita, Okamatsu, Masatoshi, Krauss, Scott, Webby, Richard J, Sakoda, Yoshihiro, Kida, Hiroshi

“…Genetic reassortment of avian, swine, and human influenza A viruses (IAVs) poses potential pandemic risks. Surveillance is important for influenza pandemic…”
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Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses by Toba, Shinsuke, Sato, Akihiko, Kawai, Makoto, Taoda, Yoshiyuki, Unoh, Yuto, Kusakabe, Shinji, Nobori, Haruaki, Uehara, Shota, Uemura, Kentaro, Taniguchi, Keiichi, Kobayashi, Masanori, Noshi, Takeshi, Yoshida, Ryu, Naito, Akira, Shishido, Takao, Maruyama, Junki, Paessler, Slobodan, Carr, Michael J, Hall, William W, Yoshimatsu, Kumiko, Arikawa, Jiro, Matsuno, Keita, Sakoda, Yoshihiro, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Kida, Hiroshi

“…Viral hemorrhagic fevers caused by members of the order comprise endemic and emerging human infections that are significant public health concerns. Despite the…”
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Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus by Baba, Keiko, Oka, Ryoko, Shano, Shinya, Omoto, Shinya, Noshi, Takeshi, Shishido, Takao, Naito, Akira, Kawaguchi, Keiko, Ishibashi, Toru, Uehara, Takeki

“…Baloxavir marboxil (BXM) demonstrated a rapid and profound decline in infectious viral titer 1 day after BXM administration. Rapid reduction in virus titer is…”
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Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation by Kobayashi, Masanori, Kodama, Makoto, Noshi, Takeshi, Yoshida, Ryu, Kanazu, Takushi, Nomura, Naoki, Soda, Kosuke, Isoda, Norikazu, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Yamano, Yoshinori, Sato, Akihiko, Kida, Hiroshi

“…High morbidity and mortality associated with human cases of highly pathogenic avian influenza (HPAI) viruses, including H5N1 influenza virus, have been…”
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