Associations between maternal pre-pregnancy body mass index and neonatal neurobehavior in infants born before 30 weeks gestation
Objective To examine the relationship between maternal pre-pregnancy body mass index (BMI) and neonatal neurobehavior in very premature infants. Study design Multi-center prospective observational study of 664 very preterm infants with 227 born to obese mothers. The NICU Network Neurobehavioral Scal...
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| Published in: | Journal of perinatology Vol. 42; no. 4; pp. 483 - 490 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
New York
Nature Publishing Group US
01-04-2022
Nature Publishing Group |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Objective
To examine the relationship between maternal pre-pregnancy body mass index (BMI) and neonatal neurobehavior in very premature infants.
Study design
Multi-center prospective observational study of 664 very preterm infants with 227 born to obese mothers. The NICU Network Neurobehavioral Scale (NNNS) assessed neurobehavior at NICU discharge.
Results
Elevated BMI combined with infection increased the odds of having the most poorly regulated NNNS profile by 1.9 times per BMI SD. Infants born to mothers with elevated BMI in combination with: infection had poorer self-regulation, chorioamnionitis had increased asymmetrical reflexes, diabetes had poorer attention, and low SES required more handling.
Conclusion
Maternal pre-pregnancy BMI alone did not affect short-term neonatal neurobehavior in infants born before 30 weeks gestation. Infants born to mothers with elevated pre-pregnancy weight in addition to infections, diabetes, or socioeconomic adversity demonstrated increased risk of having the most poorly regulated NNNS profile and deficits in multiple domains. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 Authors Contributions Lynne M. Smith was responsible for the conceptualization, data curation, investigation, and supervision of the manuscript along with the drafting and editing of the manuscript. Lynne M. Dansereau and Mary B. Roberts were responsible for the methodology, data curation, formal analysis, and resources of the manuscript as well as the drafting and editing of the manuscript. Sheri A. DellaGrotta was responsible for the methodology, investigation, data curation, and resources of the manuscript along with the editing of the manuscript. Julie A. Hofheimer was responsible for the conceptualization, methodology, investigation, supervision, funding acquisition, data curation, and resources of the manuscript along with the drafting and editing of the manuscript. Brian S. Carter, Jennifer B. Helderman, Elisabeth C. McGowan, Charles R. Neal, and Steve Pastyrnak were responsible for the methodology, investigation, and resources of the manuscript along with the editing of the manuscript. Reprint Request Author: Lynne M. Smith, MD Nina P. Nosavan was responsible for the conceptualization, investigation, and resources of the manuscript as well as the drafting and editing of the manuscript. Michael O’Shea and Barry M. Lester were responsible for the conceptualization, methodology, investigation, supervision, funding acquisition, data curation, and resources of the manuscript along with the drafting and editing of the manuscript. |
| ISSN: | 0743-8346 1476-5543 |
| DOI: | 10.1038/s41372-021-01308-y |