Search Results - "Nosaka, Emi"

Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor by Honma, Daisuke, Kanno, Osamu, Watanabe, Jun, Kinoshita, Junzo, Hirasawa, Makoto, Nosaka, Emi, Shiroishi, Machiko, Takizawa, Takeshi, Yasumatsu, Isao, Horiuchi, Takao, Nakao, Akira, Suzuki, Keisuke, Yamasaki, Tomonori, Nakajima, Katsuyoshi, Hayakawa, Miho, Yamazaki, Takanori, Yadav, Ajay Singh, Adachi, Nobuaki

“…Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 and represses gene expression to regulate cell proliferation and differentiation. Enhancer…”
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RS-1748, a Novel CC Chemokine Receptor 4 Antagonist, Inhibits Ovalbumin-Induced Airway Inflammation in Guinea Pigs by Nakagami, Yasuhiro, Kawase, Yumi, Yonekubo, Kazuki, Nosaka, Emi, Etori, Maki, Takahashi, Sakiko, Takagi, Nana, Fukuda, Takeshi, Kuribayashi, Takeshi, Nara, Futoshi, Yamashita, Makoto

“…CC chemokine receptor 4 (CCR4) is generally recognized as a preferential marker for T helper 2 cells, and we have previously reported morpholine-derivative…”
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Novel triple neurokinin receptor antagonist CS-003 inhibits respiratory disease models in guinea pigs by Tsuchida, Hiroshi, Takahashi, Sakiko, Nosaka, Emi, Kuraya, Takako, Yamashita, Makoto, Morimoto, Kiyoshi

“…Neurokinins are known to induce neurogenic inflammation related to respiratory diseases. The effects of CS-003 ([1-{2-[(…”
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Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses by Tsuchida, Hiroshi, Takahashi, Sakiko, Nosaka, Emi, Mukaiyama, Osamu, Yamashita, Makoto, Morimoto, Kiyoshi

“…Neurokinins are known to induce neurogenic inflammation related to respiratory diseases, though there is little information on triple neurokinin receptor…”
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EZH1/2 Dual Inhibitor Valemetostat Tosylate (DS-3201b) Acts Differently from EZH2 Selective Inhibitor on Epigenetic Landscape to Exert Greater Anti-Tumor Effect Against Diffuse Large B-Cell Lymphoma by Banjo, Toshihiro, Hama, Yasuhiro, Nosaka, Emi, Takata, Yoshimi, Honma, Daisuke, Kitagawa, Mayumi, Yamamoto, Yuka, Wada, Chisa, Yoshida, Takanori, Lim, Kyungtaek, Okamoto, Atsushi, Sato, Erina, Katayama, Yumiko, Sato, Kazumi, Goto, Hiroki, Abe, Yuki

“…Enhancer of zeste homologous (EZH) 2 and its close homolog EZH1 are catalytic subunits of polycomb repressive complex (PRC) 2 protein complex, and play…”
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Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model by MUKAIYAMA, Osamu, MORIMOTO, Kiyoshi, NOSAKA, Emi, TAKAHASHI, Sakiko, YAMASHITA, Makoto

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Anti-Tumor Effect of the EZH1/2 Dual Inhibitor Valemetostat Against Diffuse Large B-Cell Lymphoma Via Modulation of B-Cell Receptor Signaling and c-Myc Signaling Pathways by Hama, Yasuhiro, Banjo, Toshihiro, Honma, Daisuke, Takata, Yoshimi, Nosaka, Emi, Shiroishi, Machiko, Watanabe, Kenji, Yamamoto, Yuka, Hirata, Tsuyoshi, Nakano, Rika, Inaki, Koichiro, Goto, Hiroki, Totoki, Yusuke, Kataoka, Miki, Lim, Kyungtaek, Wada, Chisa, Kumazawa, Eiji, Tsutsumi, Shinji

“…Enhancer of zeste homolog (EZH) 1 and its close homolog EZH2 are component of polycomb repressive complex 2 (PRC2), and play a partially redundant and crucial…”
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Development and Characterization of the Novel Orally Bioavailable EZH1/2 Dual Inhibitor DS-3201 by Honma, Daisuke, Adachi, Nobuaki, Kanno, Osamu, Watanabe, Jun, Hirasawa, Makoto, Nosaka, Emi, Shiroishi, Machiko, Takizawa, Takeshi, Yasumatsu, Isao, Horiuchi, Takao, Nakao, Akira, Suzuki, Keisuke, Yamasaki, Tomonori, Nakajima, Katsuyoshi, Hayakawa, Miho, Yamazaki, Takanori, Araki, Kazushi, Fujiwara, Kosaku

“…Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 (H3K27) and represses gene expression to regulate cell proliferation and differentiation…”
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DS-3201, a Potent EZH1/2 Dual Inhibitor, Demonstrates Antitumor Activity Against Non-Hodgkin Lymphoma (NHL) Regardless of EZH2 Mutation by Honma, Daisuke, Nosaka, Emi, Shiroishi, Machiko, Takata, Yoshimi, Hama, Yasuhiro, Yamamoto, Yuka, Adachi, Nobuaki, Maruyama, Dai, Tobinai, Kensei, Ishida, Takashi, Kusumoto, Shigeru, Ishitsuka, Kenji, Imaizumi, Yoshitaka, Takeuchi, Shogo, Tsukasaki, Kunihiro, Fujioka, Tomoyuki, Watanabe, Jun, Kanno, Osamu, Kumazawa, Eiji, Fujitani, Sumiaki, Araki, Kazushi, Fujiwara, Kosaku

“…Enhancer of zests homologous (EZH)1 and its close homolog EZH2 are component of polycomb repressive complex (PRC) 2 protein complex, and play redundant and…”
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Involvement of enhanced neurokinin NK 3 receptor expression in the severe asthma guinea pig model by Mukaiyama, Osamu, Morimoto, Kiyoshi, Nosaka, Emi, Takahashi, Sakiko, Yamashita, Makoto

“…In this study, we investigated the involvement of neurokinin NK 3 receptors in a severe asthma model prepared by administering ovalbumin via inhalation three…”
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Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model by Mukaiyama, Osamu, Morimoto, Kiyoshi, Nosaka, Emi, Takahashi, Sakiko, Yamashita, Makoto

“…In this study, we investigated the involvement of neurokinin NK3 receptors in a severe asthma model prepared by administering ovalbumin via inhalation three…”
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Greater involvement of neurokinins found in Guinea pig models of severe asthma compared with mild asthma by Mukaiyama, Osamu, Morimoto, Kiyoshi, Nosaka, Emi, Takahashi, Sakiko, Yamashita, Makoto

“…Involvement of neurokinins in asthma has been previously pointed out by several reports. However, the relationship between neurokinins and the severity of…”
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O-279 - Pharmacological activities of R-113281, a novel NK1, NK2 and NK3 receptor antagonist in vivo by Satoh, Yumiko, Nosaka, Emi, Ito, Kazuhiro, Nishi, Takahide, Yamaguchi, Takeshi

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Pharmacological activities of R-113281, a novel NK1, NK2 and NK3 receptor antagonist in vivo by Satoh, Yumiko, Nosaka, Emi, Ito, Kazuhiro, Nishi, Takahide, Yamaguchi, Takeshi

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