Surgical treatment of primary locally advanced rectal cancer in Norway

Most reports on locally advanced rectal cancer come from specialized centres, with a selected patient material. The purpose of this study was to examine the results after surgical treatment of patients with locally advanced rectal cancer at a population level. National cohort study of 896 patients u...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of surgical oncology Vol. 32; no. 2; pp. 174 - 180
Main Authors:	Eriksen, M.T., Wibe, A., Hestvik, U.E., Haffner, J., Wiig, J.N., Norwegian Rectal Cancer Group, Norwegian Gastrointestinal Cancer Group
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-03-2006
Subjects:	Adenocarcinoma - epidemiology Adenocarcinoma - pathology Adenocarcinoma - radiotherapy Adenocarcinoma - surgery Adult Age Factors Aged Aged, 80 and over Cohort Studies Digestive System Surgical Procedures Female Follow-Up Studies Humans Locally advanced Male Middle Aged Multivariate Analysis National cohort study Neoplasm Invasiveness Neoplasm Recurrence, Local Neoplasm Staging Norway - epidemiology Radiotherapy, Adjuvant Rectal cancer Rectal Neoplasms - epidemiology Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Sex Factors Survival Rate Treatment Outcome Norway Rectal cancer National cohort study Locally advanced
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Most reports on locally advanced rectal cancer come from specialized centres, with a selected patient material. The purpose of this study was to examine the results after surgical treatment of patients with locally advanced rectal cancer at a population level. National cohort study of 896 patients undergoing surgery for a locally advanced primary adenocarcinoma of the rectum from November 1993 to December 2001. Surgery with resection was undertaken in 724 patients and 172 patients underwent palliative procedures. Of 557 patients treated for cure, a R0 resection was achieved in 342 (61%). In a multivariate analysis, pre-operative radiotherapy was the only factor with a positive association with R0 status (odds ratio 3.7, 95% confidence interval (CI) 2.1–6.4). Five-year local recurrence rates were 18% (CI 14–23) for R0 resections and 40% (CI 26–52) for R1 resections. Overall 5-year survival rate was 23%; for the group of patients with a R0 resection the survival rate was 49%. The radical resection rate and survival rates in this national study were similar to those reported from specialized centres.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0748-7983 1532-2157
DOI:	10.1016/j.ejso.2005.10.008