Search Results - "Norton, R S"

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes by Pennington, M W, Beeton, C, Galea, C A, Smith, B J, Chi, V, Monaghan, K P, Garcia, A, Rangaraju, S, Giuffrida, A, Plank, D, Crossley, G, Nugent, D, Khaytin, I, Lefievre, Y, Peshenko, I, Dixon, C, Chauhan, S, Orzel, A, Inoue, T, Hu, X, Moore, R V, Norton, R S, Chandy, K G

“…Kv1.3 potassium channels maintain the membrane potential of effector memory (T(EM)) T cells that are important mediators of multiple sclerosis, type 1 diabetes…”
Get more information

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator by Corzo, G, Escoubas, P, Villegas, E, Barnham, K J, He, W, Norton, R S, Nakajima, T

“…Two novel antimicrobial peptides have been identified and characterized from venom of the African scorpion Pandinus imperator. The peptides, designated…”
Get full text

A common structural motif incorporating a cystine knot and a triple‐stranded β‐sheet in toxic and inhibitory polypeptides by Pallaghy, Paul K., Norton, Raymond S., Nielsen, Katherine J., Craik, David J.

“…A common structural motif consisting of a cystine knot and a small triple‐stranded β‐sheet has been defined from comparison of the 3‐dimensional structures of…”
Get full text

Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone by Tudor, Jane E, Pallaghy, Paul K, Pennington, Michael W, Norton, Raymond S

“…The first structure of a sea anemone potassium channel toxin reveals how a novel structural scaffold can be used to present key functional groups for channel…”
Get full text

Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases by Norton, Raymond S, Pennington, Michael W, Wulff, Heike

“…Expression of the two lymphocyte potassium channels, the voltage-gated channel Kv1.3 and the calcium activated channel IKCa1, changes during differentiation of…”
Get more information

Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel by Norton, R S

“…Sea anemones produce a series of toxic polypeptides and proteins with molecular weights in the range 3000-5000 that act by binding to specific receptor sites…”
Get more information

Interaction of insulin-like growth factor (IGF)-I and -II with IGF binding protein-2: mapping the binding surfaces by nuclear magnetic resonance by Carrick, F E, Hinds, M G, McNeil, K A, Wallace, J C, Forbes, B E, Norton, R S

“…The interaction of IGF binding protein-2 (IGFBP-2) with IGF-I and -II has been investigated in solution using nuclear magnetic resonance (NMR) spectroscopy…”
Get full text

Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits by Curtain, Cyril C., Ali, Feda, Volitakis, Irene, Cherny, Robert A., Norton, Raymond S., Beyreuther, Konrad, Barrow, Colin J., Masters, Colin L., Bush, Ashley I., Barnham, Kevin J.

“…Amyloid β peptide (Aβ) is the major constituent of extracellular plaques and perivascular amyloid deposits, the pathognomonic neuropathological lesions of…”
Get full text

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat by Day, Catherine L, Hinds, Mark G, Norton, Raymond S, Vaux, David L

“…Members of the inhibitor of apoptosis (IAP) family of proteins are able to inhibit cell death following viral infection, during development or in cell lines in…”
Get full text

Designed Peptide Analogues of the Potassium Channel Blocker ShK Toxin by Lanigan, Mark D, Pennington, Michael W, Lefievre, Yann, Rauer, Heiko, Norton, Raymond S

“…ShK toxin, a potassium channel blocker from the sea anemone Stichodactyla helianthus, is a 35-residue polypeptide cross-linked by 3 disulfide bridges. In an…”
Get full text

Structures of the Contryphan Family of Cyclic Peptides. Role of Electrostatic Interactions in cis−trans Isomerism by Pallaghy, Paul K, He, Weilan, Jimenez, Elsie C, Olivera, Baldomero M, Norton, Raymond S

“…The contryphan family of cyclic peptides, isolated recently from various species of cone shell, has the conserved sequence motif NH3 +-X1COD-WX5PWC-NH2, where…”
Get full text

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis by Barnham, Kevin J, McKinstry, William J, Multhaup, Gerd, Galatis, Denise, Morton, Craig J, Curtain, Cyril C, Williamson, Nicholas A, White, Anthony R, Hinds, Mark G, Norton, Raymond S, Beyreuther, Konrad, Masters, Colin L, Parker, Michael W, Cappai, Roberto

“…A major source of free radical production in the brain derives from copper. To prevent metal-mediated oxidative stress, cells have evolved complex metal…”
Get full text

Purification and characterization of ciguatoxins from moray eel (Lycodontis javanicus, Muraenidae) by Lewis, R J, Sellin, M, Poli, M A, Norton, R S, MacLeod, J K, Sheil, M M

“…Viscera (48.3 kg) from moray eels (Lycodontis javanicus) collected in a ciguatera endemic area were extracted and the ciguatoxins characterized. Three major…”
Get more information

Refined structure in solution of the sea anemone neurotoxin ShI by Wilcox, G R, Fogh, R H, Norton, R S

“…A high resolution structure in solution has been determined for the polypeptide neurotoxin I, from the sea anemone Stichodactyla helianthus, using NMR data,…”
Get full text

The cystine knot structure of ion channel toxins and related polypeptides by Norton, Raymond S., Pallaghy, Paul K.

“…An increasing number of ion channel toxins and related polypeptides have been found to adopt a common structural motif designated the inhibitor cystine knot…”
Get full text

Novel Conotoxins from Conus striatus and Conus kinoshitai Selectively Block TTX-Resistant Sodium Channels by Bulaj, Grzegorz, West, Peter J, Garrett, James E, Watkins, Maren, Zhang, Min-Min, Norton, Raymond S, Smith, Brian J, Yoshikami, Doju, Olivera, Baldomero M

“…The peptides isolated from venoms of predatory marine Conus snails (“conotoxins”) are well-known to be highly potent and selective pharmacological agents for…”
Get full text

Role of the 6‐20 disulfide bridge in the structure and activity of epidermal growth factor by Barnham, Kevin J., Torres, Allan M., Norton, Raymond S., Alewood, Dianne, Alewood, Paul F., Domagala, Teresa, Nice, Edouard C.

“…Two synthetic analogues of murine epidermal growth factor, [Abu6, 20 mEGF4‐48 (where Abu denotes amino‐butyric acid) and [Gl, M3, K21, H40] mEGF1‐48, have been…”
Get full text

Backbone dynamics measurements on leukemia inhibitory factor, a rigid four-helical bundle cytokine by YAO, SHENGGEN, SMITH, DAVID K., HINDS, MARK G., ZHANG, JIAN-GUO, NICOLA, NICOS A., NORTON, RAYMOND S.

“…The backbone dynamics of the four-helical bundle cytokine leukemia inhibitory factor (LIF) have been investigated using 15N NMR relaxation and amide proton…”
Get full text

Solution structure of the eukaryotic pore-forming cytolysin equinatoxin II: implications for pore formation by Hinds, Mark G, Zhang, Wei, Anderluh, Gregor, Hansen, Poul Erik, Norton, Raymond S

“…Sea anemones produce a family of 18–20 kDa proteins, the actinoporins, that lyse cells by forming pores in cell membranes. Sphingomyelin plays an important…”
Get full text

Solution structure of neurotoxin I from the sea anemone Stichodactyla helianthus. A nuclear magnetic resonance, distance geometry, and restrained molecular dynamics study by FOGH, R. H, KEM, W. R, NORTON, R. S

“…The three-dimensional structure of the sea anemone polypeptide Stichodactyla helianthus neurotoxin I in aqueous solution has been determined using distance…”
Get full text