Search Results - "Norton, James C"

Pimavanserin for Parkinson's Disease psychosis: Effects stratified by baseline cognition and use of cognitive‐enhancing medications by Espay, Alberto J., Guskey, Michael T., Norton, James C., Coate, Bruce, Vizcarra, Joaquin A., Ballard, Clive, Factor, Stewart A., Friedman, Joseph H., Lang, Anthony E., Larsen, Niccole J., Andersson, Candace, Fredericks, Doral, Weintraub, Daniel

“…ABSTRACT Background: PD psychosis is often associated with cognitive impairment, including dementia, and involves dopaminergic, serotonergic, and cholinergic…”
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Parkinson's disease and Parkinson's disease psychosis: a perspective on the challenges, treatments, and economic burden by Fredericks, Doral, Norton, James C, Atchison, Carolyn, Schoenhaus, Robert, Pill, Michael W

“…Parkinson's disease (PD) is a progressive neurodegenerative disease associated with a decrease in the neurotransmitter dopamine and characterized by the…”
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Inhibition of human telomerase activity by peptide nucleic acids by Norton, James C, Piatyszek, Mieczyslaw A, Wright, Woodring E, Shay, Jerry W, Corey, David R

“…We report the inhibition of human telomerase activity by peptide nucleic acids (PNAs). PNAs recognize the RNA component of human telomerase (hTR) and inhibit…”
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Pimavanserin for the treatment of Parkinson’s disease psychosis: number needed to treat, number needed to harm, and likelihood to be helped or harmed by Citrome, Leslie, Norton, James C., Chi-Burris, Kathy, Demos, George

“…Our aim was to describe the efficacy and tolerability of pimavanserin, a highly selective serotonin 5-HT2A receptor inverse agonist/antagonist indicated for…”
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In Vitro Stability and Recovery Studies of Pimavanserin in Water and in Different Vehicles Orally Administered by Bokser, Allan David, Adegbenle, Yvonne Holmes, Stoisavljevic, Vesna, Norton, James C.

“…Background and objective Swallowing difficulties (i.e., dysphagia) occur in up to 40% of the adult general population, particularly among the elderly…”
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Long-term evaluation of open-label pimavanserin safety and tolerability in Parkinson's disease psychosis by Ballard, Clive G., Kreitzman, David L., Isaacson, Stuart, Liu, I-Yuan, Norton, James C., Demos, George, Fernandez, Hubert H., Ilic, Tihomir V., Azulay, Jean-Philippe, Ferreira, Joaquim J., Abler, Victor, Stankovic, Srdjan

“…Pimavanserin is a selective 5-HT2A inverse agonist/antagonist approved for treating hallucinations and delusions associated with Parkinson's disease psychosis…”
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Efficacy results of pimavanserin from a multi-center, open-label extension study in Parkinson's disease psychosis patients by Isaacson, Stuart H., Ballard, Clive G., Kreitzman, David L., Coate, Bruce, Norton, James C., Fernandez, Hubert H., Ilic, Tihomir V., Azulay, Jean-Philippe, Ferreira, Joaquim J., Abler, Victor, Stankovic, Srdjan

“…Pimavanserin, a selective 5-HT2A inverse agonist/antagonist, was approved for hallucinations and delusions associated with Parkinson's disease psychosis (PDP)…”
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158 Open-label Study of Pimavanserin Patients with Comorbid Parkinson's Disease and Depression by Guskey, Michael T, Alva, Gustavo, Aldred, Jason L, Coate, Bruce, DeKarske, Daryl, Cantillon, Marc, Norton, James C

“…Depression occurs in ~50% of Parkinson's disease (PD) patients, increases in severity and duration as the disease progresses, and is associated with increased…”
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CPR to the Rescue!: An Interprofessional Pilot Program: Cultivating Practices for Resilience (CPR) Camp by Heath, Janie, Walmsley, Lee Anne, Aker, Rachelle M., Ferrin, Shelley, Stone, Dan, Norton, James C.

“…The hCATS (health Colleges Advancing Team Skills) to CPR (Cultivating Practices for Resilience) Camp was an interprofessional pilot program to promote…”
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Use of Pimavanserin in Combination with Selective Serotonin Reuptake Inhibitors (SSRIs) by Norton, James C., PhD, Fredericks, Doral, PharmD, MBA, Chi-Burris, Kathy, MPH, Owen, Randy, MD

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Dissemination of Evidence From Systematic Reviews Through Academic CME Providers: A Feasibility Study by Fordis, Michael, King, Jason E, Bonaduce de Nigris, Francesca, Morrow, Robert, Baron, Robert B, Kues, John R, Norton, James C, Kessler, Harold, Mazmanian, Paul E, Colburn, Lois

“…Although systematic reviews represent a source of best evidence to support clinical decision-making, reviews are underutilized by clinicians. Barriers include…”
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Enhancement of strand invasion by oligonucleotides through manipulation of backbone charge by Smulevitch, Sergey V, Simmons, Carla G, Norton, James C, Wise, Teresa W, Corey, David R

“…The ability of DNA oligonucleotides, neutral peptide nucleic acids (PNAS), and oligonucleotide conjugates to hybridize to inverted repeat sequences within…”
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Poster Number: NR 39 - Use of Pimavanserin in Combination with Selective Serotonin Reuptake Inhibitors (SSRIs) by Norton, James C., Fredericks, Doral, Chi-Burris, Kathy, Owen, Randy

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Specific and nonspecific inhibition of transcription by DNA, PNA, and phosphorothioate promoter analog duplexes by Hamilton, Susan E., Iyer, Mridula, Norton, James C., Corey, David R.

“…DNA duplexes analogous to the promoters for SP6 or T7 RNA polymerase inhibit transcription with exquisite selectivity. By contrast, phosphorothioate oligomers…”
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Comparison of the telomeric repeat amplification protocol (TRAP) to the new TRAP-eze telomerase detection kit by HOLT, S. E, NORTON, J. C, WRIGHT, W. E, SHAY, J. W

“…The ribonucleoprotein, telomerase, is believed to be responsible for the maintenance of telomere length in immortal and cancer cells. A PCR-based assay for the…”
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Accelerated Hybridization of Oligonucleotides to Duplex DNA by Iyer, Mridula, Norton, James C., Corey, David R.

“…We report two strategies for accelerating the hybridization of oligonucleotides to DNA. We demonstrate that oligodeoxyribonucleotides and peptide nucleic acid…”
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Patterns of neuropsychological test performance in Huntington's disease by Norton, J C

“…Neuropsychological test performance of Huntington's disease (HD) and a mixed brain-damaged group were compared. Wechsler patterns in the present samples were…”
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Object, Intensity and Subject Variables in Visual Evoked Response by Norton, James C.

“…10 subjects were studied to determine AEP effects of square, circle, and blank stimuli with variable stimulus intensity For the group as a whole, object and…”
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Medical problems of the alcoholic in nonmedical treatment by Penick, E C, Norton, J C, Sauers, C A, Powell, B J, Read, M R

“…The ambivalence about chronic alcohol abuse among health and related professionals can result in their failure to appreciate medical complications frequently…”
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Retinal Degeneration slow (rds) in Mouse Results from Simple Insertion of a t Haplotype-Specific Element into Protein-Coding Exon II by Ma, Jianshan, Norton, James C., Allen, Ann C., Burns, Jeffrey B., Hasel, Karl W., Burns, John L., Sutcliffe, J.Gregor, Travis, Gabriel H.

“…Retinal degeneration slow (rds) is a semidominant mutation of mice that causes dysplasia and degeneration of rod and cone photoreceptors. Mutations in RDS, the…”
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