Search Results - "Northup, J"

Modification of human 5-HT2C receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution by OKADA, M, NORTHUP, J. K, OZAKI, N, RUSSELL, J. T, LINNOILA, M, GOLDMAN, D

“…A human serotonin (5-HT)(2C) receptor gene polymorphism leads to the substitution of cysteine for serine at codon 23 (Cys23Ser); the frequency of the Ser23…”
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Position Effects Due to Chromosome Breakpoints that Map similar to 900 Kb Upstream and similar to 1.3 Mb Downstream of SOX9 in Two Patients with Campomelic Dysplasia by Velagaleti, GVN, Bien-Willner, G A, Northup, J K, Lockhart, L H, Hawkins, J C, Jalal, S M, Withers, M, Lupski, J R, Stankiewicz, P

“…Campomelic dysplasia (CD) is a semilethal skeletal malformation syndrome with or without XY sex reversal. In addition to the multiple mutations found within…”
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Laparoscopic gastric banding in a kidney–pancreas transplant recipient with new onset type II diabetes mellitus associated with morbid obesity by Bonatti, H., Schmitt, T., Northup, J., Schirmer, B., Swenson, B.R., Pruett, T.L., Sawyer, R.G., Brayman, K.

“…:  Combined kidney–pancreas transplantation is the treatment of choice for end‐stage diabetic nephropathy. Post‐transplant weight gain increases the risk for…”
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Molecular cytogenetic characterization of a familial der(1)del(1)(p36.33)dup(1)(p36.33p36.22) with variable phenotype by Tonk, Vijay S., Wilson, Golder N., Yatsenko, Svetlana A., Stankiewicz, Pawel, Lupski, James R., Schutt, Robert C., Northup, J.K., Velagaleti, Gopalrao V.N.

“…Chromosome deletions involving 1p36 are the most common known terminal rearrangements occurring at a frequency of ∼1 in 5,000 live births. In contrast,…”
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Independent and synergistic interaction of retinal G-protein subunits with bovine rhodopsin measured by surface plasmon resonance by Clark, W A, Jian, X, Chen, L, Northup, J K

“…We have used surface plasmon resonance (SPR) measurements for the kinetic analysis of G-protein-receptor interaction monitored in real time. Functionally…”
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Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase by Bokoch, G M, Katada, T, Northup, J K, Ui, M, Gilman, A G

“…Attenuation of GTP-dependent inhibition of adenylate cyclase by islet-activating protein (pertussis toxin) is due to the ability of the toxin to catalyze the…”
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The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein by Katada, T, Bokoch, G M, Northup, J K, Ui, M, Gilman, A G

“…Treatment of membranes with islet activating protein (IAP), a toxin from Bordetella pertussis, results in abolition of GTP-dependent, receptor-mediated…”
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The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition by Katada, T, Northup, J K, Bokoch, G M, Ui, M, Gilman, A G

“…The inhibitory and stimulatory guanine nucleotide-binding regulatory components (Gi and Gs) of adenylate cyclase both have an alpha X beta subunit structure,…”
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The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit by Northup, J K, Smigel, M D, Sternweis, P C, Gilman, A G

“…Activation of the stimulatory guanine nucleotide-binding regulatory component (G/F) of adenylate cyclase by guanine nucleotides or by Al3+, Mg2+, and…”
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Purification of the major GTP-binding proteins from human placental membranes by Evans, T, Brown, M L, Fraser, E D, Northup, J K

“…Using minor modifications of procedures developed to purify GTP-binding proteins (G-proteins) from rabbit liver, we have purified the major G-proteins present…”
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The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding by Northup, J K, Smigel, M D, Gilman, A G

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Identification of the predominant substrate for ADP-ribosylation by islet activating protein by Bokoch, G M, Katada, T, Northup, J K, Hewlett, E L, Gilman, A G

“…Islet activating protein (IAP), a toxin isolated from Bordetella pertussis, blocks the ability of inhibitory hormones to attenuate adenylate cyclase activity…”
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Steady-state levels of G-proteins and beta-adrenergic receptors in rat fat cells. Permissive effects of thyroid hormones by Ros, M, Northup, J K, Malbon, C C

“…Thyroid hormones exert a permissive influence on the ability of cells to respond to other hormones. In hypothyroidism, stimulation of adenylate cyclase by…”
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The Influence of a Token Economy and Methylphenidate on Attentive and Disruptive Behavior during Sports with Adhd-Diagnosed Children by Reitman, David, Hupp, Stephen D. A., O’Callaghan, Patrick M., Gulley, Veronica, Northup, John

“…Three children diagnosed with attention deficit hyperactivity disorder (ADHD) participated in a summer program designed to evaluate the influence of stimulant…”
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G Protein Diversity is Increased by Associations with a Variety of γ Subunits by Gautam, Narasimhan, Northup, John, Tamir, Haya, Simon, Melvin I.

“…Guanine nucleotide-binding regulatory proteins (G proteins) are heterotrimeric proteins that transduce extracellular signals into intracellular changes…”
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Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization by Waldo, G L, Northup, J K, Perkins, J P, Harden, T K

“…Incubation of 1321N1 human astrocytoma cells with 1 microM isoproterenol rapidly results in the conversion of a portion of the beta-adrenergic receptors to a…”
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Safety Evaluation of Medical Devices: US Food and Drug Administration and International Standards Organization Guidelines by Northup, Sharon J.

“…During the last 20 years, safety evaluation of medical devices has evolved from screening assays to the “pharmaceutical model” of preclinical testing…”
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Functional expression of the taste specific G-protein, alpha-gustducin by Hoon, M A, Northup, J K, Margolskee, R F, Ryba, N J

“…The taste-specific G-protein alpha-subunit, alpha-gustducin, was expressed using a baculovirus based system. alpha-Gustducin was demonstrated to be…”
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The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit by Northup, J K, Sternweis, P C, Gilman, A G

“…The stimulatory guanine nucleotide-binding regulatory component (G/F) of adenylate cyclase is activated by exposure to guanine nucleotide analogs or to Al3+ +…”
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Specificity of Action of Guanine Nucleotide-Binding Regulatory Protein Subunits on the Cardiac Muscarinic K+ Channel by Logothetis, Diomedes E., Kim, Donghee, Northup, John K., Neer, Eva J., Clapham, David E.

“…The cardiac muscarinic receptor stimulates a potassium-selective ionic current (IK.ACh) through activation of a guanine nucleotide-binding regulatory protein…”
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