Search Results - "Northoff, Bernd H."

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans by Holdt, Lesca M., Stahringer, Anika, Sass, Kristina, Pichler, Garwin, Kulak, Nils A., Wilfert, Wolfgang, Kohlmaier, Alexander, Herbst, Andreas, Northoff, Bernd H., Nicolaou, Alexandros, Gäbel, Gabor, Beutner, Frank, Scholz, Markus, Thiery, Joachim, Musunuru, Kiran, Krohn, Knut, Mann, Matthias, Teupser, Daniel

“…Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular…”
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Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms by Sadler, Rebecca, Cramer, Julia V, Heindl, Steffanie, Kostidis, Sarantos, Betz, Dene, Zuurbier, Kielen R, Northoff, Bernd H, Heijink, Marieke, Goldberg, Mark P, Plautz, Erik J, Roth, Stefan, Malik, Rainer, Dichgans, Martin, Holdt, Lesca M, Benakis, Corinne, Giera, Martin, Stowe, Ann M, Liesz, Arthur

“…Recovery after stroke is a multicellular process encompassing neurons, resident immune cells, and brain-invading cells. Stroke alters the gut microbiome, which…”
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Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal by Skoglund, Pontus, Northoff, Bernd H., Shunkov, Michael V., Derevianko, Anatoli P., Pääbo, Svante, Krause, Johannes, Jakobsson, Mattias

“…One of the main impediments for obtaining DNA sequences from ancient human skeletons is the presence of contaminating modern human DNA molecules in many fossil…”
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RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke by Tiedt, Steffen, Prestel, Matthias, Malik, Rainer, Schieferdecker, Nicola, Duering, Marco, Kautzky, Veronika, Stoycheva, Ivelina, Böck, Julia, Northoff, Bernd H, Klein, Matthias, Dorn, Franziska, Krohn, Knut, Teupser, Daniel, Liesz, Arthur, Plesnila, Nikolaus, Holdt, Lesca Miriam, Dichgans, Martin

“…RATIONALE:Currently, there are no blood-based biomarkers with clinical utility for acute ischemic stroke (IS). MicroRNAs show promise as disease markers…”
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Whole genome sequencing of Brucella melitensis isolated from 57 patients in Germany reveals high diversity in strains from Middle East by Georgi, Enrico, Walter, Mathias C, Pfalzgraf, Marie-Theres, Northoff, Bernd H, Holdt, Lesca M, Scholz, Holger C, Zoeller, Lothar, Zange, Sabine, Antwerpen, Markus H

“…Brucellosis, a worldwide common bacterial zoonotic disease, has become quite rare in Northern and Western Europe. However, since 2014 a significant increase of…”
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Molecular Fingerprint for Terminal Abdominal Aortic Aneurysm Disease by Gäbel, Gabor, Northoff, Bernd H., Weinzierl, Irina, Ludwig, Stefan, Hinterseher, Irene, Wilfert, Wolfgang, Teupser, Daniel, Doderer, Stefan A., Bergert, Hendrik, Schönleben, Frank, Lindeman, Jan H. N., Holdt, Lesca M.

“…Background Clinical decision making in abdominal aortic aneurysms (AAA) relies completely on diameter. At this point, improved decision tools remain an unmet…”
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Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression by Gäbel, Gabor, Northoff, Bernd H, Balboa, Amanda, Becirovic-Agic, Mediha, Petri, Marcelo, Busch, Albert, Maegdefessel, Lars, Mahlmann, Adrian, Ludwig, Stefan, Teupser, Daniel, de Waard, Vivian, Golledge, Jonathan, Wanhainen, Anders, Wågsäter, Dick, Holdt, Lesca M, Lindeman, Jan H N

“…Background While numerous interventions effectively interfered with abdominal aortic aneurysm (AAA) formation/progression in preclinical models, none of the…”
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Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice by Nicolaou, Alexandros, Zhao, Zhen, Northoff, Bernd H, Sass, Kristina, Herbst, Andreas, Kohlmaier, Alexander, Chalaris, Athena, Wolfrum, Christian, Weber, Christian, Steffens, Sabine, Rose-John, Stefan, Teupser, Daniel, Holdt, Lesca M

“…OBJECTIVE—ADAM17 (a disintegrin and metalloproteinase 17) is a sheddase releasing different types of membrane-bound proteins, including adhesion molecules,…”
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Detection of a Parkinson's Disease-Specific MicroRNA Signature in Nasal and Oral Swabs by Schließer, Patricia, Struebing, Felix L, Northoff, Bernd H, Kurz, Anna, Rémi, Jan, Holdt, Lesca, Höglinger, Günter U, Herms, Jochen, Koeglsperger, Thomas

“…Biomaterials from oral and nasal swabs provide, in theory, a potential resource for biomarker development. However, their diagnostic value has not yet been…”
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Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer by Bernhart, Stephan H., Kretzmer, Helene, Holdt, Lesca M., Jühling, Frank, Ammerpohl, Ole, Bergmann, Anke K., Northoff, Bernd H., Doose, Gero, Siebert, Reiner, Stadler, Peter F., Hoffmann, Steve

“…Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epigenetic marks at…”
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Adventitial adipogenic degeneration is an unidentified contributor to aortic wall weakening in the abdominal aortic aneurysm by Doderer, Stefan A., Gäbel, Gabor, Kokje, Vivianne B.C., Northoff, Bernd H., Holdt, Lesca M., Hamming, Jaap F., Lindeman, Jan H.N.

“…The processes driving human abdominal aortic aneurysm (AAA) progression are not fully understood. Although antiinflammatory and proteolytic strategies…”
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Quantitative trait locus mapping in mice identifies phospholipase Pla2g12a as novel atherosclerosis modifier by Nicolaou, Alexandros, Northoff, Bernd H., Sass, Kristina, Ernst, Jana, Kohlmaier, Alexander, Krohn, Knut, Wolfrum, Christian, Teupser, Daniel, Holdt, Lesca M.

“…In a previous work, a female-specific atherosclerosis risk locus on chromosome (Chr) 3 was identified in an intercross of atherosclerosis-resistant FVB and…”
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Differential expression of gut miRNAs in idiopathic Parkinson's disease by Kurz, Anna, Kumar, Rohit, Northoff, Bernd H., Wenk, Catharina, Schirra, Jörg, Donakonda, Sainitin, Höglinger, Günter U., Schwarz, Johannes, Rozanski, Verena, Hübner, Rainer, Bötzel, Kai, Holdt, Lesca Miriam, Koeglsperger, Thomas

“…In the present work, we aimed to investigate the expression of microRNAs (miRNAs) in routine colonic biopsies obtained from patients with idiopathic…”
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IL-6: A Janus-like factor in abdominal aortic aneurysm disease by Kokje, Vivianne B.C, Gäbel, Gabor, Koole, Dave, Northoff, Bernd H, Holdt, Lesca M, Hamming, Jaap F, Lindeman, Jan H.N

“…Abstract Background and aims An abdominal aortic aneurysm (AAA) is part of the atherosclerotic spectrum of diseases. The disease is hallmarked by a…”
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The ADAM17 Metalloproteinase Maintains Arterial Elasticity by Nicolaou, Alexandros, Northoff, Bernd H, Zhao, Zhen, Kohlmaier, Alexander, Sass, Kristina, Rose-John, Stefan, Steffens, Sabine, Weber, Christian, Teupser, Daniel, Holdt, Lesca M

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CXCL8 hyper-signaling in the aortic abdominal aneurysm by Kokje, Vivianne B.C., Gäbel, Gabor, Dalman, Ron L., Koole, Dave, Northoff, Bernd H., Holdt, Lesca M., Hamming, Jaap F., Lindeman, Jan H.N.

“…•Abdominal Aortic Aneurysmal disease is associated with CXCL8 hyper expression.•The CXCL-8 receptors CXCR1 and -2 are abundantly expression in the aneurysm…”
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Abstract 142: Transcriptome-wide Expression Quantitative Trait Loci Mapping for Atherosclerosis Susceptibility Reveals Surf4 as Novel Candidate Gene by Northoff, Bernd H, Sass, Kristina, Nicolaou, Alexandros, Teupser, Daniel, Holdt, Lesca

“…Abstract only Previous work in an F2 intercross between atherosclerosis-susceptible C57BL/6 and atherosclerosis-resistant BALB/cByJ (BALB) mice on the…”
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Abstract 663: Identification of 2 Novel Candidate Genes of Atherosclerosis Susceptibility on Mouse Chromosome 3: Pla2g12a and Elovl6 by Nicolaou, Alexandros, Sass, Kristina, Northoff, Bernd H, Teupser, Daniel, Holdt, Lesca M

“…Abstract only Quantitative trait locus (QTL) mapping in an F2 intercross (n=452) of atherosclerosis-susceptible C57BL/6 (B6) and atherosclerosis-resistant FVB…”
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Separating endogenous ancient DNA from modern-day contamination: application to a Siberian Neandertal by Skoglund, Pontus, Northoff, Bernd H, Shunkov, Michael V, Derevianko, Anatoli P, Pääbo, Svante, Krause, Johannes, Jakobsson, Mattias

“…One of the main impediments for obtaining DNA sequences from ancient humanskeletons is the presence of contaminating modern human DNA molecules in many fossil…”
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Determining histone H4 acetylation patterns in human peripheral blood mononuclear cells using mass spectrometry by Bux, Esther Marie, Solis-Mezarino, Victor, Kuhm, Christoph, Northoff, Bernd H., Karin, Ivan, Klopstock, Thomas, Holdt, Lesca M., Völker-Albert, Moritz, Imhof, Axel, Peleg, Shahaf

“…•Histone acetylations can be precisely quantified in hPBMCs.•Histone H4 acetylation changes specifically during ageing.•Age-related changes are evolutionary…”
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