Search Results - "Northcote, Peter T."

Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A by Prota, Andrea E., Bargsten, Katja, Northcote, Peter T., Marsh, May, Altmann, Karl-Heinz, Miller, John H., Díaz, José Fernando, Steinmetz, Michel O.

“…Laulimalide and peloruside A are microtubule‐stabilizing agents (MSAs), the mechanism of action on microtubules of which is poorly defined. Here, using X‐ray…”
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Chemical Reactions on Surface Molecules Attached to Silicon Quantum Dots by Shiohara, Amane, Hanada, Sanshiro, Prabakar, Sujay, Fujioka, Kohki, Lim, Teck H, Yamamoto, Kenji, Northcote, Peter T, Tilley, Richard D

“…This Article describes research on chemical reactions on molecules attached to the surface of silicon quantum dots that have been performed to produce quantum…”
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Natural Products from Tongan Marine Organisms by Taufa, Taitusi, Subramani, Ramesh, Northcote, Peter, Keyzers, Robert

“…The islands of the South Pacific Ocean have been in the limelight for natural product biodiscovery, due to their unique and pristine tropical waters and…”
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The Oxeatamides: Nitrogenous Spongian Diterpenes from the New Zealand Marine Sponge Darwinella oxeata by Wojnar, Joanna M, Dowle, Katie O, Northcote, Peter T

“…As part of our ongoing search for novel and bioactive compounds from New Zealand marine organisms, we investigated the extracts of the sponge Darwinella…”
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Resistance to peloruside A and laulimalide: functional significance of acquired βI-tubulin mutations at sites important for drug-tubulin binding by Kanakkanthara, Arun, Eras, Jonathan, Northcote, Peter T, Cabral, Fernando, Miller, John H

“…Cancer cell lines selected for resistance to microtubule targeting agents (MTA) often have acquired mutations in the β-tubulin binding sites for these agents…”
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Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide by Miller, John H, Singh, A Jonathan, Northcote, Peter T

“…Marine sponges are an excellent source of bioactive secondary metabolites with potential therapeutic value in the treatment of diseases. One group of compounds…”
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Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly by Hamel, Ernest, Day, Billy W, Miller, John H, Jung, M Katherine, Northcote, Peter T, Ghosh, Arun K, Curran, Dennis P, Cushman, Mark, Nicolaou, K C, Paterson, Ian, Sorensen, Erik J

“…Previous studies on the drug content of pelleted tubulin polymers suggest that peloruside A binds in the laulimalide site, which is distinct from the taxoid…”
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Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and Peloruside A by Crume, Kevin P., O'Sullivan, David, Miller, John H., Northcote, Peter T., La Flamme, Anne C.

“…Microtubule‐stabilizing drugs able to delay the onset of CNS disease in an MS mouse model depends on altering both the lymphoid and myeloid cell compartments…”
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Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease by Kanakkanthara, Arun, Northcote, Peter T, Miller, John H

“…Covering: 2000 up to 2016Peloruside A, a macrocyclic secondary metabolite from a New Zealand marine sponge, Mycale hentscheli, has shown potent…”
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Marine natural products by Blunt, John W, Copp, Brent R, Munro, Murray H G, Northcote, Peter T, Prinsep, Michèle R

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Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts by Storey, Mathew A, Andreassend, Sarah K, Bracegirdle, Joe, Brown, Alistair, Keyzers, Robert A, Ackerley, David F, Northcote, Peter T, Owen, Jeremy G

“…Marine sponges have been a prolific source of unique bioactive compounds that are presumed to act as a deterrent to predation. Many of these compounds have…”
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Marine natural products by Blunt, John W, Copp, Brent R, Hu, Wan-Ping, Munro, Murray H G, Northcote, Peter T, Prinsep, Michèle R

“…This review covers the literature published in 2007 for marine natural products, with 948 citations(627 for the period January to December 2007) referring to…”
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Marine natural products by Blunt, John W, Copp, Brent R, Munro, Murray H G, Northcote, Peter T, Prinsep, Michèle R

“…This review covers the literature published in 2008 for marine natural products, with 829 citations (613 for the period January to December 2008) referring to…”
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Marine Invertebrate Natural Products that Target Microtubules by Miller, John H, Field, Jessica J, Kanakkanthara, Arun, Owen, Jeremy G, Singh, A. Jonathan, Northcote, Peter T

“…Marine natural products as secondary metabolites are a potential major source of new drugs for treating disease. In some cases, cytotoxic marine metabolites…”
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Two new 4-methylidene containing steroids, craterol A and B, from the New Zealand two sponge association between Stelletta crater and Desmacella dendyi by Taufa, Taitusi, Northcote, Peter T., Keyzers, Robert A.

“…[Display omitted] •Two new members of the rare 4-methylidene class of sterol have been isolated.•These compounds are the first natural products from either of…”
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Marine natural products by Blunt, John W, Copp, Brent R, Hu, Wan-Ping, Munro, Murray H G, Northcote, Peter T, Prinsep, Michèle R

“…This review covers the literature published in 2006 for marine natural products, with 758 citations (534 for the period January to December 2006) referring to…”
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Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole by Meyer, Kirsten J, Singh, A Jonathan, Cameron, Alanna, Tan, An S, Leahy, Dora C, O'Sullivan, David, Joshi, Praneta, La Flamme, Anne C, Northcote, Peter T, Berridge, Michael V, Miller, John H

“…Mycothiazole, a polyketide metabolite isolated from the marine sponge Cacospongia mycofijiensis, is a potent inhibitor of metabolic activity and mitochondrial…”
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Sized controlled synthesis, purification, and cell studies with silicon quantum dots by Shiohara, Amane, Prabakar, Sujay, Faramus, Angelique, Hsu, Chia-Yen, Lai, Ping-Shan, Northcote, Peter T, Tilley, Richard D

“…This article describes the size control synthesis of silicon quantum dots with simple microemulsion techniques. The silicon nanocrystals are small enough to be…”
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Marine natural products by Blunt, John W, Copp, Brent R, Hu, Wan-Ping, Munro, Murray H G, Northcote, Peter T, Prinsep, Michèle R

“…This review covers the literature published in 2005 for marine natural products, with 704 citations (493 for the period January to December 2005) referring to…”
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Halogenated Meroditerpenoids from a South Pacific Collection of the Red Alga Callophycus serratus by Woolner, Victoria H, Gordon, Rose M. A, Miller, John H, Lein, Matthias, Northcote, Peter T, Keyzers, Robert A

“…A detailed examination of the red alga Callophycus serratus collected in Tonga led to the isolation of six new halogenated meroditerpenoids: callophycol C (1),…”
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