Search Results - "North, Kari E."

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations by Tcheandjieu, Catherine, Zhu, Xiang, Hilliard, Austin T., Clarke, Shoa L., Napolioni, Valerio, Ma, Shining, Lee, Kyung Min, Fang, Huaying, Chen, Fei, Lu, Yingchang, Tsao, Noah L., Raghavan, Sridharan, Koyama, Satoshi, Gorman, Bryan R., Vujkovic, Marijana, Klarin, Derek, Levin, Michael G., Sinnott-Armstrong, Nasa, Wojcik, Genevieve L., Plomondon, Mary E., Maddox, Thomas M., Waldo, Stephen W., Bick, Alexander G., Pyarajan, Saiju, Huang, Jie, Song, Rebecca, Ho, Yuk-Lam, Buyske, Steven, Kooperberg, Charles, Haessler, Jeffrey, Loos, Ruth J. F., Do, Ron, Verbanck, Marie, Chaudhary, Kumardeep, North, Kari E., Avery, Christy L., Graff, Mariaelisa, Haiman, Christopher A., Le Marchand, Loïc, Wilkens, Lynne R., Bis, Joshua C., Leonard, Hampton, Shen, Botong, Lange, Leslie A., Giri, Ayush, Dikilitas, Ozan, Kullo, Iftikhar J., Stanaway, Ian B., Jarvik, Gail P., Gordon, Adam S., Hebbring, Scott, Namjou, Bahram, Kaufman, Kenneth M., Ito, Kaoru, Ishigaki, Kazuyoshi, Kamatani, Yoichiro, Verma, Shefali S., Ritchie, Marylyn D., Kember, Rachel L., Baras, Aris, Lotta, Luca A., Kathiresan, Sekar, Hauser, Elizabeth R., Miller, Donald R., Lee, Jennifer S., Saleheen, Danish, Reaven, Peter D., Cho, Kelly, Gaziano, J. Michael, Natarajan, Pradeep, Huffman, Jennifer E., Voight, Benjamin F., Rader, Daniel J., Chang, Kyong-Mi, Lynch, Julie A., Damrauer, Scott M., Wilson, Peter W. F., Tang, Hua, Sun, Yan V., Tsao, Philip S., O’Donnell, Christopher J., Assimes, Themistocles L.

“…We report a genome-wide association study (GWAS) of coronary artery disease (CAD) incorporating nearly a quarter of a million cases, in which existing studies…”
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Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data by Shungin, Dmitry, Haworth, Simon, Divaris, Kimon, Agler, Cary S., Kamatani, Yoichiro, Keun Lee, Myoung, Grinde, Kelsey, Hindy, George, Alaraudanjoki, Viivi, Pesonen, Paula, Teumer, Alexander, Holtfreter, Birte, Sakaue, Saori, Hirata, Jun, Yu, Yau-Hua, Ridker, Paul M., Giulianini, Franco, Chasman, Daniel I., Magnusson, Patrik K. E., Sudo, Takeaki, Okada, Yukinori, Völker, Uwe, Kocher, Thomas, Anttonen, Vuokko, Laitala, Marja-Liisa, Orho-Melander, Marju, Sofer, Tamar, Shaffer, John R., Vieira, Alexandre, Marazita, Mary L., Kubo, Michiaki, Furuichi, Yasushi, North, Kari E., Offenbacher, Steve, Ingelsson, Erik, Franks, Paul W., Timpson, Nicholas J., Johansson, Ingegerd

“…Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here,…”
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Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity by Kaplan, Robert C, Wang, Zheng, Usyk, Mykhaylo, Sotres-Alvarez, Daniela, Daviglus, Martha L, Schneiderman, Neil, Talavera, Gregory A, Gellman, Marc D, Thyagarajan, Bharat, Moon, Jee-Young, Vázquez-Baeza, Yoshiki, McDonald, Daniel, Williams-Nguyen, Jessica S, Wu, Michael C, North, Kari E, Shaffer, Justin, Sollecito, Christopher C, Qi, Qibin, Isasi, Carmen R, Wang, Tao, Knight, Rob, Burk, Robert D

“…Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on the gut microbiome. We report a cross-sectional analysis of…”
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A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos by Feofanova, Elena V., Chen, Han, Dai, Yulin, Jia, Peilin, Grove, Megan L., Morrison, Alanna C., Qi, Qibin, Daviglus, Martha, Cai, Jianwen, North, Kari E., Laurie, Cathy C., Kaplan, Robert C., Boerwinkle, Eric, Yu, Bing

“…Variation in levels of the human metabolome reflect changes in homeostasis, providing a window into health and disease. The genetic impact on circulating…”
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GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation by Offenbacher, Steven, Jiao, Yizu, Kim, Steven J., Marchesan, Julie, Moss, Kevin L., Jing, Li, Divaris, Kimon, Bencharit, Sompop, Agler, Cary S., Morelli, Thiago, Zhang, Shaoping, Sun, Lu, Seaman, William T., Cowley, Dale, Barros, Silvana P., Beck, James D., Munz, Matthias, Schaefer, Arne S., North, Kari E.

“…There is no agnostic GWAS evidence for the genetic control of IL-1β expression in periodontal disease. Here we report a GWAS for “high” gingival crevicular…”
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Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes by Menni, Cristina, Zhu, Jialing, Le Roy, Caroline I, Mompeo, Olatz, Young, Kristin, Rebholz, Casey M., Selvin, Elizabeth, North, Kari E., Mohney, Robert P, Bell, Jordana T, Boerwinkle, Eric, Spector, Tim D, Mangino, Massimo, Yu, Bing, Valdes, Ana M

“…Type 2 diabetes (T2D) is associated with reduced gut microbiome diversity, although the cause is unclear. Metabolites generated by gut microbes also appear to…”
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Microbial co-occurrence complicates associations of gut microbiome with US immigration, dietary intake and obesity by Wang, Zheng, Usyk, Mykhaylo, Vázquez-Baeza, Yoshiki, Chen, Guo-Chong, Isasi, Carmen R, Williams-Nguyen, Jessica S, Hua, Simin, McDonald, Daniel, Thyagarajan, Bharat, Daviglus, Martha L, Cai, Jianwen, North, Kari E, Wang, Tao, Knight, Rob, Burk, Robert D, Kaplan, Robert C, Qi, Qibin

“…Obesity and related comorbidities are major health concerns among many US immigrant populations. Emerging evidence suggests a potential involvement of the gut…”
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Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study by Carlson, Christopher S, Matise, Tara C, North, Kari E, Haiman, Christopher A, Fesinmeyer, Megan D, Buyske, Steven, Schumacher, Fredrick R, Peters, Ulrike, Franceschini, Nora, Ritchie, Marylyn D, Duggan, David J, Spencer, Kylee L, Dumitrescu, Logan, Eaton, Charles B, Thomas, Fridtjof, Young, Alicia, Carty, Cara, Heiss, Gerardo, Le Marchand, Loic, Crawford, Dana C, Hindorff, Lucia A, Kooperberg, Charles L

“…The vast majority of genome-wide association study (GWAS) findings reported to date are from populations with European Ancestry (EA), and it is not yet clear…”
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Selenomonas sputigena acts as a pathobiont mediating spatial structure and biofilm virulence in early childhood caries by Cho, Hunyong, Ren, Zhi, Divaris, Kimon, Roach, Jeffrey, Lin, Bridget M., Liu, Chuwen, Azcarate-Peril, M. Andrea, Simancas-Pallares, Miguel A., Shrestha, Poojan, Orlenko, Alena, Ginnis, Jeannie, North, Kari E., Zandona, Andrea G. Ferreira, Ribeiro, Apoena Aguiar, Wu, Di, Koo, Hyun

“…Streptococcus mutans has been implicated as the primary pathogen in childhood caries (tooth decay). While the role of polymicrobial communities is appreciated,…”
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GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk by Pirastu, Nicola, Joshi, Peter K., de Vries, Paul S., Cornelis, Marilyn C., McKeigue, Paul M., Keum, NaNa, Franceschini, Nora, Colombo, Marco, Giovannucci, Edward L., Spiliopoulou, Athina, Franke, Lude, North, Kari E., Kraft, Peter, Morrison, Alanna C., Esko, Tõnu, Wilson, James F.

“…Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50;…”
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Genetic Association Analysis under Complex Survey Sampling: The Hispanic Community Health Study/Study of Latinos by Lin, Dan-Yu, Tao, Ran, Kalsbeek, William D., Zeng, Donglin, Gonzalez, Franklyn, Fernández-Rhodes, Lindsay, Graff, Mariaelisa, Koch, Gary G., North, Kari E., Heiss, Gerardo

“…The cohort design allows investigators to explore the genetic basis of a variety of diseases and traits in a single study while avoiding major weaknesses of…”
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Epigenome-wide methylation and progression to high-grade cervical intraepithelial neoplasia (CIN2+): a prospective cohort study in the United States by Bukowski, Alexandra, Hoyo, Cathrine, Vielot, Nadja A, Graff, Misa, Kosorok, Michael R, Brewster, Wendy R, Maguire, Rachel L, Murphy, Susan K, Nedjai, Belinda, Ladoukakis, Efthymios, North, Kari E, Smith, Jennifer S

“…Methylation levels may be associated with and serve as markers to predict risk of progression of precancerous cervical lesions. We conducted an epigenome-wide…”
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Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos by Hodonsky, Chani J, Jain, Deepti, Schick, Ursula M, Morrison, Jean V, Brown, Lisa, McHugh, Caitlin P, Schurmann, Claudia, Chen, Diane D, Liu, Yong Mei, Auer, Paul L, Laurie, Cecilia A, Taylor, Kent D, Browning, Brian L, Li, Yun, Papanicolaou, George, Rotter, Jerome I, Kurita, Ryo, Nakamura, Yukio, Browning, Sharon R, Loos, Ruth J F, North, Kari E, Laurie, Cathy C, Thornton, Timothy A, Pankratz, Nathan, Bauer, Daniel E, Sofer, Tamar, Reiner, Alex P

“…Prior GWAS have identified loci associated with red blood cell (RBC) traits in populations of European, African, and Asian ancestry. These studies have not…”
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Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction by WILK, Jemma B, SHRINE, Nick R. G, LOTH, Daan W, CURJURIC, Ivan, JENNIE HUI, CHO, Michael H, LATOURELLE, Jeanne C, HENRY, Amanda P, ALDRICH, Melinda, BAKKE, Per, BEATY, Terri H, BENTLEY, Amy R, LOEHR, Laura R, BORECKI, Ingrid B, BRUSSELLE, Guy G, BURKART, Kristin M, CHEN, Ting-Hsu, COUPER, David, CRAPO, James D, DAVIES, Gail, DUPUIS, Josee, FRANCESCHINI, Nora, GULSVIK, Amund, JING HUA ZHAO, HANCOCK, Dana B, HARRIS, Tamara B, HOFMAN, Albert, IMBODEN, Medea, JAMES, Alan L, KHAW, Kay-Tee, LAHOUSSE, Lies, LAUNER, Lenore J, LITONJUA, Augusto, YONGMEI LIU, MANICHAIKUL, Ani, LOHMAN, Kurt K, LOMAS, David A, LUMLEY, Thomas, MARCIANTE, Kristin D, MCARDLE, Wendy L, MEIBOHM, Bernd, MORRISON, Alanna C, MUSK, Arthur W, MYERS, Richard H, NORTH, Kari E, LOPEZ, LornaM, POSTMA, Dirkje S, PSATY, Bruce M, RICH, Stephen S, RIVADENEIRA, Fernando, ROCHAT, Thierry, ROTTER, Jerome I, SOLER ARTIGAS, Maria, STARR, John M, UITTERLINDEN, André G, WAREHAM, Nicholas J, VERNONSMITH, Albert, HECKBERT, Susan R, SMOLONSKA, Joanna, WENBO TANG

“…Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD)…”
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Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family Study by Tinkelman, Naomi E., Spratlen, Miranda Jones, Domingo-Relloso, Arce, Tellez-Plaza, Maria, Grau-Perez, Maria, Francesconi, Kevin A., Goessler, Walter, Howard, Barbara V., MacCluer, Jean, North, Kari E., Umans, Jason G., Factor-Litvak, Pam, Cole, Shelley A., Navas-Acien, Ana

“…•Maternal arsenic exposure may play a role in risk for adult-onset type 2 diabetes.•Maternal arsenic exposure has a greater effect on diabetes than adult…”
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Novel Insights into the Effects of Genetic Variants on Serum Urate Response to an Acute Fructose Challenge: A Pilot Study by Zhang, Xinruo, Mass, Baba B, Talevi, Valentina, Hou, Ruixue, North, Kari E, Voruganti, Venkata Saroja

“…Studies have shown that genetic variations can influence metabolic response to nutrient intake, and that diets rich in fructose contribute to hyperuricemia. In…”
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Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children by Hou, Ruixue, Cole, Shelley A., Graff, Mariaelisa, Haack, Karin, Laston, Sandra, Comuzzie, Anthony G., Mehta, Nitesh R., Ryan, Kathleen, Cousminer, Diana L., Zemel, Babette S., Grant, Struan F.A., Mitchell, Braxton D., Shypailo, Roman J., Gourlay, Margaret L., North, Kari E., Butte, Nancy F., Voruganti, V. Saroja

“…Osteoporosis is a major public health burden with significant economic costs. However, the correlates of bone health in Hispanic children are understudied. We…”
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Longitudinal impact of physical activity on lipid profiles in middle-aged adults: the Atherosclerosis Risk in Communities Study[S] by Monda, Keri L., Ballantyne, Christie M., North, Kari E.

“…Evidence exists that increased levels of physical activity decrease the population burden of cardiovascular disease (CVD). Although risk factors for CVD,…”
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Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics by Hodonsky, Chani J, Baldassari, Antoine R, Bien, Stephanie A, Raffield, Laura M, Highland, Heather M, Sitlani, Colleen M, Wojcik, Genevieve L, Tao, Ran, Graff, Marielisa, Tang, Weihong, Thyagarajan, Bharat, Buyske, Steve, Fornage, Myriam, Hindorff, Lucia A, Li, Yun, Lin, Danyu, Reiner, Alex P, North, Kari E, Loos, Ruth J F, Kooperberg, Charles, Avery, Christy L

“…Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait…”
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A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses by Baranski, Thomas J, Kraja, Aldi T, Fink, Jill L, Feitosa, Mary, Lenzini, Petra A, Borecki, Ingrid B, Liu, Ching-Ti, Cupples, L Adrienne, North, Kari E, Province, Michael A

“…Human GWAS of obesity have been successful in identifying loci associated with adiposity, but for the most part, these are non-coding SNPs whose function, or…”
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