Search Results - "North, K. E."

BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort by Graff, M, North, K E, Richardson, A S, Young, K L, Mazul, A L, Highland, H M, Mohlke, K L, Lange, L A, Lange, E M, Mullan Harris, K, Gordon-Larsen, P

“…Objective: The association of obesity susceptibility variants with change in body mass index (BMI) across the life course is not well understood. Subjects: In…”
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Chronic Periodontitis Genome-wide Association Studies: Gene-centric and Gene Set Enrichment Analyses by Rhodin, K., Divaris, K., North, K.E., Barros, S.P., Moss, K., Beck, J.D., Offenbacher, S.

“…Recent genome-wide association studies (GWAS) of chronic periodontitis (CP) offer rich data sources for the investigation of candidate genes, functional…”
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PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: The NHLBI Family Heart Study by Graff, M, North, K E, Franceschini, N, Reiner, A P, Feitosa, M, Carr, J J, Gordon-Larsen, P, Wojczynski, M K, Borecki, I B

“…BACKGROUND: Fatty liver disease (FLD) is characterized by increased intrahepatic triglyceride content with or without inflammation and is associated with…”
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Cyclooxygenase Polymorphisms and Risk of Cardiovascular Events: The Atherosclerosis Risk in Communities (ARIC) Study by Lee, C R, North, K E, Bray, M S, Couper, D J, Heiss, G, Zeldin, D C

“…Cyclooxygenase‐derived prostaglandins modulate cardiovascular disease risk. We genotyped 2212 Atherosclerosis Risk in Communities study participants (1,023…”
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Genome-wide Association Study of Periodontal Pathogen Colonization by Divaris, K., Monda, K.L., North, K.E., Olshan, A.F., Lange, E.M., Moss, K., Barros, S.P., Beck, J.D., Offenbacher, S.

“…Pathological shifts of the human microbiome are characteristic of many diseases, including chronic periodontitis. To date, there is limited evidence on host…”
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Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study / Study of Latinos by Sanders, A.E., Sofer, T., Wong, Q., Kerr, K.F., Agler, C., Shaffer, J.R., Beck, J.D., Offenbacher, S., Salazar, C.R., North, K.E., Marazita, M.L., Laurie, C.C., Singer, R.H., Cai, J., Finlayson, T.L., Divaris, K.

“…Chronic periodontitis (CP) has a genetic component, particularly its severe forms. Evidence from genome-wide association studies (GWASs) has highlighted…”
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TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study by Bielinski, S. J, Pankow, J. S, Folsom, A. R, North, K. E, Boerwinkle, E

“…Aims/hypothesis We hypothesised that TCF7L2 single nucleotide polymorphisms (SNPs) are associated with cardiovascular disease (CVD) and that the associations…”
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Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart Family Study by Franceschini, N., Haack, K., Göring, H. H. H., Voruganti, V. S., Laston, S., Almasy, L., Lee, E. T., Best, L. G., Fabsitz, R. R., North, K. E., MacCluer, J. W., Meigs, J. B., Pankow, J. S., Cole, S. A.

“…Aims/hypothesis Type 2 diabetes is a chronic, heterogeneous disease and a major risk factor for cardiovascular diseases. The underlying mechanisms leading to…”
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Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study by Justice, A.E., Chittoor, G., Blanco, E., Graff, M., Wang, Y., Albala, C., Santos, J.L., Angel, B., Lozoff, B., Voruganti, V.S., North, K.E., Gahagan, S.

“…Summary Background While the genetic contribution to obesity is well established, few studies have examined how genetic variants influence standardized body…”
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Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort by Richardson, A. S., North, K. E., Graff, M., Young, K. M., Mohlke, K. L., Lange, L. A., Lange, E. M., Harris, K. M., Gordon-Larsen, P.

“…Summary What is already known about this subject Genome‐Wide Association Studies have successfully identified numerous genetic loci that influence body mass…”
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The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter? by Graff, M., Richardson, A.S., Young, K.L., Mazul, A.L., Highland, Heather, North, K.E., Mohlke, K.L., Lange, L.A., Lange, E.M., Harris, K.M., Gordon-Larsen, P.

“…Little is known about how obesity susceptibility single nucleotide polymorphisms (SNPs) interact with moderate to vigorous physical activity (MVPA) in relation…”
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Influence of SNPSNP interaction on BMI in European American adolescents: findings from the National Longitudinal Study of Adolescent Health by Young, K. L., Graff, M., North, K. E., Richardson, A. S., Bradfield, J. P., Grant, S. F. A., Lange, L. A., Lange, E. M., Harris, K. M., Gordon-Larsen, P.

“…Summary Background Adolescent obesity is predictive of future weight gain, obesity and adult onset severe obesity (body mass index [BMI] ≥40 kg m−2). Despite…”
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Generalization of adiposity genetic loci to US Hispanic women by Graff, M, Fernández-Rhodes, L, Liu, S, Carlson, C, Wassertheil-Smoller, S, Neuhouser, M, Reiner, A, Kooperberg, C, Rampersaud, E, Manson, J E, Kuller, L H, Howard, B V, Ochs-Balcom, H M, Johnson, K C, Vitolins, M Z, Sucheston, L, Monda, K, North, K E

“…BACKGROUND: Obesity is a public health concern. Yet the identification of adiposity-related genetic variants among United States (US) Hispanics, which is the…”
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Exploring the genetic basis of chronic periodontitis: a genome-wide association study by Divaris, Kimon, Monda, Keri L, North, Kari E, Olshan, Andrew F, Reynolds, Lindsay M, Hsueh, Wen-Chi, Lange, Ethan M, Moss, Kevin, Barros, Silvana P, Weyant, Robert J, Liu, Yongmei, Newman, Anne B, Beck, James D, Offenbacher, Steven

“…Chronic periodontitis (CP) is a common oral disease that confers substantial systemic inflammatory and microbial burden and is a major cause of tooth loss…”
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Screen time behaviours may interact with obesity genes, independent of physical activity, to influence adolescent BMI in an ethnically diverse cohort by Graff, M., North, K. E., Richardson, A. S., Young, K. M., Mohlke, K. L., Lange, L. A., Lange, E. M., Harris, K. M., Gordon-Larsen, P.

“…Summary Background There has been little investigation of gene‐by‐environment interactions related to sedentary behaviour, a risk factor for obesity defined as…”
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Sex-specific findings from a genome-wide linkage analysis of human fatness in non-Hispanic whites and African Americans: The HyperGEN Study by LEWIS, C. E, NORTH, K. E, MILLER, M. B, ARNETT, D, BORECKI, I. B, COON, H, ELLISON, R. C, HUNT, S. C, OBERMAN, A, RICH, S. S, PROVINCE, M. A

“…To conduct a full genome search for genes potentially influencing two related phenotypes: body mass index (BMI, kg/m2) and percent body fat (PBF) from…”
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Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health by Graff, M, North, K E, Mohlke, K L, Lange, L A, Luo, J, Harris, K M, Young, K L, Richardson, A S, Lange, E M, Gordon-Larsen, P

“…Objective: The contribution of genetic variants to body mass index (BMI) during adolescence across multiethnic samples is largely unknown. We selected genetic…”
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Linkage analysis of LDL cholesterol in American Indian populations: the Strong Heart Family Study by North, K. E, Goring, H. H. H, Cole, S. A, Diego, V. P, Almasy, L, Laston, S, Cantu, T, Howard, B. V, Lee, E. T, Best, L. G, Fabsitz, R. R, MacCluer, J. W

“…Previous studies have demonstrated that low density lipoprotein cholesterol (LDL-C) concentration is influenced by both genes and environment. Although rare…”
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Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche by Sarnowski, C, Cousminer, D L, Franceschini, N, Raffield, L M, Jia, G, Fernández-Rhodes, L, Grant, S F A, Hakonarson, H, Lange, L A, Long, J, Sofer, T, Tao, R, Wallace, R B, Wong, Q, Zirpoli, G, Boerwinkle, E, Bradfield, J P, Correa, A, Kooperberg, C L, North, K E, Palmer, J R, Zemel, B S, Zheng, W, Murabito, J M, Lunetta, K L

“…Does the expansion of genome-wide association studies (GWAS) to a broader range of ancestries improve the ability to identify and generalise variants…”
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Genotype-by-sex interaction in the aetiology of type 2 diabetes mellitus : support for sex-specific quantitative trait loci in Hypertension Genetic Epidemiology Network participants by AVERY, C. L, FREEDMAN, B. I, NORTH, K. E, KRAJA, A. T, BORECKI, I. B, MILLER, M. B, PANKOW, J. S, ARNETT, D, LEWIS, C. E, MYERS, R. H, HUNT, S. C

“…While there are sex-related differences in both the prevalence of type 2 diabetes mellitus and disease risk factors, there is only limited research on…”
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