Search Results - "North, Jeffrey"

Merkel cell carcinoma: An update and review: Pathogenesis, diagnosis, and staging by Coggshall, Kathleen, Tello, Tiffany L, North, Jeffrey P, Yu, Siegrid S

“…Merkel cell carcinoma (MCC) is an uncommon primary cutaneous neuroendocrine cancer. It most commonly presents as an indurated plaque or nodule on sun-damaged…”
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New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics by North, E Jeffrey, Jackson, Mary, Lee, Richard E

“…Mycolic acids are the major lipid components of the unique mycobacterial cell wall responsible for the protection of the tuberculosis bacilli from many outside…”
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The Association of Interleukin-36 Staining Intensity and Response to Biologic Therapy in Patients With Psoriasis: A Retrospective Immunohistochemical and Chart Review Pilot Study by Zhang, William R, Bhutani, Tina, North, Jeffrey P

“…There are limited surrogate biomarkers to identify the active inflammatory pathway in psoriasis to direct treatment with targeted biologic therapies. We…”
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Clinicopathologic overlap of psoriasis, eczema, and psoriasiform dermatoses: A retrospective study of T helper type 2 and 17 subsets, interleukin 36, and β-defensin 2 in spongiotic psoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor α inhibitor–associated dermatitis by Cohen, Jarish N., Bowman, Sarah, Laszik, Zoltan G., North, Jeffrey P.

“…T helper (Th) type 17 and Th2 cells mediate psoriasis and eczema, respectively. Some dermatoses exhibit overlapping clinicopathologic features, and their…”
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Targeted Genomic Profiling of Acral Melanoma by Yeh, Iwei, Jorgenson, Eric, Shen, Ling, Xu, Mengshu, North, Jeffrey P, Shain, A Hunter, Reuss, David, Wu, Hong, Robinson, William A, Olshen, Adam, von Deimling, Andreas, Kwok, Pui-Yan, Bastian, Boris C, Asgari, Maryam M

“…Abstract Background Acral melanoma is a rare type of melanoma that affects world populations irrespective of skin color and has worse survival than other…”
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The Genetic Evolution of Melanoma from Precursor Lesions by Shain, A. Hunter, Yeh, Iwei, Kovalyshyn, Ivanka, Sriharan, Aravindhan, Talevich, Eric, Gagnon, Alexander, Dummer, Reinhard, North, Jeffrey, Pincus, Laura, Ruben, Beth, Rickaby, William, D’Arrigo, Corrado, Robson, Alistair, Bastian, Boris C

“…Genetic analysis of melanomas from 37 patients sampled in 150 different areas showed that BRAF mutations were present from the first stages of tumor…”
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Patch‐type granuloma annulare: An institution‐based study of 23 cases by Khanna, Urmi, North, Jeffrey P.

“…Background Granuloma annulare (GA) is a skin disorder of uncertain etiology. Patch (type) GA is an uncommon variant of GA with a paucity of data characterizing…”
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Histopathologic features of cutaneous leishmaniasis and use of CD1a staining for amastigotes in Old World and New World leishmaniasis by Sundharkrishnan, Lohini, North, Jeffrey P.

“…Background Positive CD1a staining of Leishmania has been reported in Old World leishmaniasis, but the sensitivity of such staining for other Leishmania species…”
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Genomic Analysis of Pigmented Epithelioid Melanocytomas Reveals Recurrent Alterations in PRKAR1A, and PRKCA Genes by Cohen, Jarish N, Joseph, Nancy M, North, Jeffrey P, Onodera, Courtney, Zembowicz, Artur, LeBoit, Philip E

“…Pigmented epithelioid melanocytoma (PEM) is a rare cutaneous melanocytic tumor first described as epithelioid blue nevus in patients with the Carney Complex…”
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The utility of PRAME staining in identifying malignant transformation of melanocytic nevi by Lohman, Mary E., Steen, Aaron J., Grekin, Roy C., North, Jeffrey P.

“…Background PReferentially expressed Antigen in MElanoma (PRAME) immunohistochemical (IHC) staining is used to aid melanoma diagnosis. PRAME expression in…”
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Utility of IL‐36 immunostaining in distinguishing psoriasis from pityriasis rosea and pityriasis lichenoides by Ibraheim, Marina Kristy, North, Jeffrey P.

“…Background Psoriasis is an inflammatory skin disease driven by upregulation of cytokines in the Th17 pathway, including interleukin‐36 (IL‐36). Previous…”
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Cutaneous and pulmonary sarcoidosis-like reaction associated with ipilimumab by Reule, Ross B., MD, North, Jeffrey P., MD

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Recurrent inverse necrotizing infundibular crystalline folliculitis by Ibraheim, Marina Kristy, Storey, Leslie, North, Jeffrey P

“…Necrotizing infundibular crystalline folliculitis (NICF) is a rare type of necrotizing folliculitis. The disease typically manifests as folliculocentric…”
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Spitz melanoma is a distinct subset of spitzoid melanoma by Raghavan, Shyam S., Peternel, Sandra, Mully, Thaddeus W., North, Jeffrey P., Pincus, Laura B., LeBoit, Philip E., McCalmont, Timothy H., Bastian, Boris C., Yeh, Iwei

“…Melanomas that have histopathologic features that overlap with those of Spitz nevus are referred to as spitzoid melanomas. However, the diagnostic concept is…”
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Interleukin 36 expression in psoriasis variants and other dermatologic diseases with psoriasis‐like histopathologic features by Aquino, Terese Monette, Calvarido, Mary Grace, North, Jeffrey P.

“…Background Elevated epidermal interleukin (IL)‐36 expression distinguishes psoriasis from eczematous dermatitis, but other psoriasiform dermatitides (PDs) have…”
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Positive MITF and NKI/C3 Expression in Cellular Neurothekeoma and Dermatofibroma by Abdaljaleel, Maram, North, Jeffrey P.

“…Cellular neurothekeoma (CNT) is a benign mesenchymal tumor with uncertain cellular differentiation. Studies have found evidence of myofibroblastic…”
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The association of interleukin-36 staining intensity with histopathologic findings of eosinophil count and spongiosis in patients with psoriasis: A secondary analysis of a retrospective immunohistochemical and chart review pilot study by Zhang, William R, Bhutani, Tina, Schulman, Joshua M, North, Jeffrey P

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Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma by North, Jeffrey P., Golovato, Justin, Vaske, Charles J., Sanborn, J. Zachary, Nguyen, Andrew, Wu, Wei, Goode, Benjamin, Stevers, Meredith, McMullen, Kevin, Perez White, Bethany E., Collisson, Eric A., Bloomer, Michele, Solomon, David A., Benz, Stephen C., Cho, Raymond J.

“…Sebaceous carcinomas (SeC) are cutaneous malignancies that, in rare cases, metastasize and prove fatal. Here we report whole-exome sequencing on 32 SeC,…”
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Large‐cell variant of Merkel cell carcinoma with clear‐cell change by Khanna, Urmi, North, Jeffrey P.

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Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses by Nguyen, Khang D., MD, Lee, Eunice E., BA, Yue, Yangbo, PhD, Stork, Jiri, MD, Pock, Lumir, MD, North, Jeffrey P., MD, Vandergriff, Travis, MD, Cockerell, Clay, MD, Hosler, Gregory A., MD, PhD, Pastrana, Diana V., PhD, Buck, Christopher B., PhD, Wang, Richard C., MD, PhD

“…Background Human polyomavirus (HPyV)6 and HPyV7 are shed chronically from human skin. HPyV7, but not HPyV6, has been linked to a pruritic skin eruption of…”
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