Search Results - "North, Brian J."

The Intersection Between Aging and Cardiovascular Disease by North, Brian J, Sinclair, David A

“…The average lifespan of humans is increasing, and with it the percentage of people entering the 65 and older age group is growing rapidly and will continue to…”
Get full text

Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis by North, Brian J, Verdin, Eric

“…The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the cytoplasm where it functions as a tubulin deacetylase. Here we report that…”
Get full text

Unraveling the Molecular Nexus between GPCRs, ERS, and EMT by Kumari, Niti, Reabroi, Somrudee, North, Brian J.

“…G protein-coupled receptors (GPCRs) represent a large family of transmembrane proteins that transduce an external stimulus into a variety of cellular…”
Get full text

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy by Gao, Yang, Nihira, Naoe Taira, Bu, Xia, Chu, Chen, Zhang, Jinfang, Kolodziejczyk, Aleksandra, Fan, Yizeng, Chan, Ngai Ting, Ma, Leina, Liu, Jing, Wang, Dong, Dai, Xiaoming, Liu, Huadong, Ono, Masaya, Nakanishi, Akira, Inuzuka, Hiroyuki, North, Brian J., Huang, Yu-Han, Sharma, Samanta, Geng, Yan, Xu, Wei, Liu, X. Shirley, Li, Lei, Miki, Yoshio, Sicinski, Piotr, Freeman, Gordon J., Wei, Wenyi

“…Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1 as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have…”
Get full text

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy by Ohnstad, Amelia E, Delgado, Jose M, North, Brian J, Nasa, Isha, Kettenbach, Arminja N, Schultz, Sebastian W, Shoemaker, Christopher J

“…Autophagosome formation requires multiple autophagy‐related (ATG) factors. However, we find that a subset of autophagy substrates remains robustly targeted to…”
Get full text

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function by Price, Nathan L., Gomes, Ana P., Ling, Alvin J.Y., Duarte, Filipe V., Martin-Montalvo, Alejandro, North, Brian J., Agarwal, Beamon, Ye, Lan, Ramadori, Giorgio, Teodoro, Joao S., Hubbard, Basil P., Varela, Ana T., Davis, James G., Varamini, Behzad, Hafner, Angela, Moaddel, Ruin, Rolo, Anabela P., Coppari, Roberto, Palmeira, Carlos M., de Cabo, Rafael, Baur, Joseph A., Sinclair, David A.

“…Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but whether SIRT1 mediates these benefits is the subject of debate. To…”
Get full text

The Role of Molecular and Cellular Aging Pathways on Age-Related Hearing Loss by Ege, Tuba, Tao, Litao, North, Brian J

“…Aging, a complex process marked by molecular and cellular changes, inevitably influences tissue and organ homeostasis and leads to an increased onset or…”
Get full text

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site by Rumpf, Tobias, Schiedel, Matthias, Karaman, Berin, Roessler, Claudia, North, Brian J., Lehotzky, Attila, Oláh, Judit, Ladwein, Kathrin I., Schmidtkunz, Karin, Gajer, Markus, Pannek, Martin, Steegborn, Clemens, Sinclair, David A., Gerhardt, Stefan, Ovádi, Judit, Schutkowski, Mike, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred

“…Sirtuins are a highly conserved class of NAD + -dependent lysine deacylases. The human isotype Sirt2 has been implicated in the pathogenesis of cancer,…”
Get full text

Functional analysis of deubiquitylating enzymes in tumorigenesis and development by Cheng, Ji, Guo, Jianping, North, Brian J., Wang, Bin, Cui, Chun-Ping, Li, Hongchang, Tao, Kaixiong, Zhang, Lingqiang, Wei, Wenyi

“…Deubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from ubiquitylated substrates to antagonize the modification mediated by E3…”
Get full text

Functional analysis of Cullin 3 E3 ligases in tumorigenesis by Cheng, Ji, Guo, Jianping, Wang, Zhiwei, North, Brian J., Tao, Kaixiong, Dai, Xiangpeng, Wei, Wenyi

“…Cullin 3-RING ligases (CRL3) play pivotal roles in the regulation of various physiological and pathological processes, including neoplastic events. The…”
Get full text

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan by North, Brian J, Rosenberg, Michael A, Jeganathan, Karthik B, Hafner, Angela V, Michan, Shaday, Dai, Jing, Baker, Darren J, Cen, Yana, Wu, Lindsay E, Sauve, Anthony A, van Deursen, Jan M, Rosenzweig, Anthony, Sinclair, David A

“…Mice overexpressing the mitotic checkpoint kinase gene BubR1 live longer, whereas mice hypomorphic for BubR1 (BubR1 H/H ) live shorter and show signs of…”
Get full text

Regulation of Insulin Secretion by SIRT4, a Mitochondrial ADP-ribosyltransferase by Ahuja, Nidhi, Schwer, Bjoern, Carobbio, Stefania, Waltregny, David, North, Brian J., Castronovo, Vincenzo, Maechler, Pierre, Verdin, Eric

“…Sirtuins are homologues of the yeast transcriptional repressor Sir2p and are conserved from bacteria to humans. We report that human SIRT4 is localized to the…”
Get full text

Mitotic Regulation of SIRT2 by Cyclin-dependent Kinase 1-dependent Phosphorylation by North, Brian J., Verdin, Eric

“…Sirtuins are evolutionarily conserved NAD+-dependent deacetylases and ADP-ribosyltransferases involved in the regulation of cell division, apoptosis, DNA…”
Get full text

Genetic fusions favor tumorigenesis through degron loss in oncogenes by Liu, Jing, Tokheim, Collin, Lee, Jonathan D., Gan, Wenjian, North, Brian J., Liu, X. Shirley, Pandolfi, Pier Paolo, Wei, Wenyi

“…Chromosomal rearrangements can generate genetic fusions composed of two distinct gene sequences, many of which have been implicated in tumorigenesis and…”
Get full text

Interplay between protein acetylation and ubiquitination controls MCL1 protein stability by Shimizu, Kouhei, Gi, Min, Suzuki, Shugo, North, Brian J., Watahiki, Asami, Fukumoto, Satoshi, Asara, John M., Tokunaga, Fuminori, Wei, Wenyi, Inuzuka, Hiroyuki

“…The anti-apoptotic myeloid cell leukemia 1 (MCL1) protein belongs to the pro-survival BCL2 family and is frequently amplified or elevated in human cancers…”
Get full text

Editorial: Post-translational modifications of proteins in cancer immunity and immunotherapy by Dai, Xiangpeng, Zhang, Jinfang, North, Brian J., Guo, Jianping

Get full text

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function by Nihira, Naoe T, Ogura, Kohei, Shimizu, Kouhei, North, Brian J, Zhang, Jinfang, Gao, Daming, Inuzuka, Hiroyuki, Wei, Wenyi

“…Abnormal activation of the oncogenic E3 ubiquitin ligase murine double minute 2 (MDM2) is frequently observed in human cancers. By ubiquitinating the tumor…”
Get more information

Enhancement of pomalidomide anti-tumor response with ACY-241, a selective HDAC6 inhibitor by North, Brian J, Almeciga-Pinto, Ingrid, Tamang, David, Yang, Min, Jones, Simon S, Quayle, Steven N

“…Thalidomide-based Immunomodulatory Drugs (IMiDs®), including lenalidomide and pomalidomide, are effective therapeutics for multiple myeloma. These agents have…”
Get full text

E3 ubiquitin ligases in cancer stem cells: key regulators of cancer hallmarks and novel therapeutic opportunities by Zou, Qiang, Liu, Meng, Liu, Kewei, Zhang, Yi, North, Brian J., Wang, Bin

“…Background Human malignancies are composed of heterogeneous subpopulations of cancer cells with phenotypic and functional diversity. Among them, a unique…”
Get full text

Isolation, Purification, and Culture of Primary Murine Sensory Neurons by Katzenell, Sarah, Cabrera, Jorge R, North, Brian J, Leib, David A

“…Cultured primary neurons have been of extraordinary value for the study of neuronal anatomy, cell biology, and physiology. While use of neuronal cell lines has…”
Get more information