Search Results - "Norris, Russell A"

The Living Scar – Cardiac Fibroblasts and the Injured Heart by Rog-Zielinska, Eva A, Norris, Russell A, Kohl, Peter, Markwald, Roger

“…Cardiac scars, often dubbed ‘dead tissue’, are very much alive, with heterocellular activity contributing to the maintenance of structural and mechanical…”
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Co-occurrence of tethered cord syndrome and cervical spine instability in hypermobile Ehlers-Danlos syndrome by Gensemer, Cortney, Daylor, Victoria, Nix, Jared, Norris, Russell A, Patel, Sunil

“…The Ehlers-Danlos Syndromes (EDS) represent a group of hereditary connective tissue disorders, with the hypermobile subtype (hEDS) being the most prevalent…”
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Descriptors of Cytochrome Inhibitors and Useful Machine Learning Based Methods for the Design of Safer Drugs by Beck, Tyler C, Beck, Kyle R, Morningstar, Jordan, Benjamin, Menny M, Norris, Russell A

“…Roughly 2.8% of annual hospitalizations are a result of adverse drug interactions in the United States, representing more than 245,000 hospitalizations…”
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Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart by Wessels, Andy, van den Hoff, Maurice J.B., Adamo, Richard F., Phelps, Aimee L., Lockhart, Marie M., Sauls, Kimberly, Briggs, Laura E., Norris, Russell A., van Wijk, Bram, Perez-Pomares, Jose M., Dettman, Robert W., Burch, John B.E.

“…The importance of the epicardium for myocardial and valvuloseptal development has been well established; perturbation of epicardial development results in…”
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Mitral Valve Prolapse and Its Motley Crew-Syndromic Prevalence, Pathophysiology, and Progression of a Common Heart Condition by Morningstar, Jordan E, Nieman, Annah, Wang, Christina, Beck, Tyler, Harvey, Andrew, Norris, Russell A

“…Mitral valve prolapse (MVP) is a commonly occurring heart condition defined by enlargement and superior displacement of the mitral valve leaflet(s) during…”
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The exocyst is required for photoreceptor ciliogenesis and retinal development by Lobo, Glenn P., Fulmer, Diana, Guo, Lilong, Zuo, Xiaofeng, Dang, Yujing, Kim, Seok-Hyung, Su, Yanhui, George, Kola, Obert, Elisabeth, Fogelgren, Ben, Nihalani, Deepak, Norris, Russell A., Rohrer, Bärbel, Lipschutz, Joshua H.

“…We previously have shown that the highly conserved eight-protein exocyst trafficking complex is required for ciliogenesis in kidney tubule cells. We…”
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Hypermobile Ehlers-Danlos syndrome and spontaneous CSF leaks: the connective tissue conundrum by Severance, Sydney, Daylor, Victoria, Petrucci, Taylor, Gensemer, Cortney, Patel, Sunil, Norris, Russell A

“…Collagen, the most abundant protein in the body, is a key component of the extracellular matrix (ECM), which plays a crucial role in the structure and support…”
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Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues by Norris, Russell A., Damon, Brook, Mironov, Vladimir, Kasyanov, Vladimir, Ramamurthi, Anand, Moreno-Rodriguez, Ricardo, Trusk, Thomas, Potts, Jay D., Goodwin, Richard L., Davis, Jeff, Hoffman, Stanley, Wen, Xuejun, Sugi, Yukiko, Kern, Christine B., Mjaatvedt, Corey H., Turner, Debi K., Oka, Toru, Conway, Simon J., Molkentin, Jeffery D., Forgacs, Gabor, Markwald, Roger R.

“…Periostin is predominantly expressed in collagen‐rich fibrous connective tissues that are subjected to constant mechanical stresses including: heart valves,…”
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Periostin mediates vascular smooth muscle cell migration through the integrins ανβ3 and ανβ5 and focal adhesion kinase (FAK) pathway by Li, Guohong, Jin, Rong, Norris, Russell A, Zhang, Lin, Yu, Shiyong, Wu, Fusheng, Markwald, Roger R, Nanda, Anil, Conway, Simon J, Smyth, Susan S, Granger, D. Neil

“…Abstract Smooth muscle cell (SMC) migration involves interactions of integrin receptors with extracellular matrix (ECM) and is an important process of…”
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Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis by Morningstar, Jordan E, Gensemer, Cortney, Moore, Reece, Fulmer, Diana, Beck, Tyler C, Wang, Christina, Moore, Kelsey, Guo, Lilong, Sieg, Franz, Nagata, Yasufumi, Bertrand, Philippe, Spampinato, Ricardo A, Glover, Janiece, Poelzing, Stephen, Gourdie, Robert G, Watts, Kelsey, Richardson, William J, Levine, Robert A, Borger, Michael A, Norris, Russell A

“…Background Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging…”
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Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho/PI 3-kinase by Butcher, Jonathan T., Norris, Russell A., Hoffman, Stanley, Mjaatvedt, Corey H., Markwald, Roger R.

“…Recent evidence suggests that extracellular matrix components may play a signaling role in embryonic valve development. We have previously identified the…”
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BMP-2 induces cell migration and periostin expression during atrioventricular valvulogenesis by Inai, Kei, Norris, Russell A., Hoffman, Stanley, Markwald, Roger R., Sugi, Yukiko

“…Atrioventricular (AV) endocardium transforms into the cushion mesenchyme, the primordia of the valves and membranous septa, through epithelial–mesenchymal…”
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Application of Pharmacokinetic Prediction Platforms in the Design of Optimized Anti-Cancer Drugs by Beck, Tyler C, Springs, Kendra, Morningstar, Jordan E, Mills, Catherine, Stoddard, Andrew, Guo, Lilong, Moore, Kelsey, Gensemer, Cortney, Biggs, Rachel, Petrucci, Taylor, Kwon, Jennie, Stayer, Kristina, Koren, Natalie, Dunne, Jaclyn, Fulmer, Diana, Vohra, Ayesha, Mai, Le, Dooley, Sarah, Weninger, Julianna, Peterson, Yuri, Woster, Patrick, Dix, Thomas A, Norris, Russell A

“…Cancer is the second most common cause of death in the United States, accounting for 602,350 deaths in 2020. Cancer-related death rates have declined by 27%…”
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Characterization of Green Fluorescent Protein in Heart Valves of a Transgenic Swine Model for Partial Heart Transplant Research by Bishara, Katherine, Kwon, Jennie H, Hill, Morgan A, Helke, Kristi L, Norris, Russell A, Whitworth, Kristin, Prather, Randall S, Rajab, Taufiek Konrad

“…A transgenic strain of pigs was created to express green fluorescent protein (GFP) ubiquitously using a pCAGG promoter. Here, we characterize GFP expression in…”
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Ischemia-Reperfusion Injury in Porcine Aortic Valvular Endothelial and Interstitial Cells by Kwon, Jennie H, Atteya, Miriam, Mitta, Alekhya, Vogel, Andrew D, Norris, Russell A, Rajab, Taufiek Konrad

“…Ischemia-reperfusion injury (IRI) in the myocardium has been thoroughly researched, especially in acute coronary syndrome and heart transplantation. However,…”
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The C-C Chemokine Receptor Type 4 Is an Immunomodulatory Target of Hydroxychloroquine by Beck, Tyler C, Beck, Kyle R, Holloway, Calvin B, Hemings, Jr, Richard A, Dix, Thomas A, Norris, Russell A

“…The emergence of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) in China, reported to the World Health Organization on December 31,…”
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Collagen Fibrillogenesis in the Mitral Valve: It's a Matter of Compliance by Goodwin, Richard L, Kheradvar, Arash, Norris, Russell A, Price, Robert L, Potts, Jay D

“…Collagen fibers are essential structural components of mitral valve leaflets, their tension apparatus (chordae tendineae), and the associated papillary…”
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The many facets of the matricelluar protein periostin during cardiac development, remodeling, and pathophysiology by Norris, Russell A., Moreno-Rodriguez, Ricardo, Hoffman, Stanley, Markwald, Roger R.

“…Periostin is a member of a growing family of matricellular proteins, defined by their ability to interact with components of the extracellular milieu, and with…”
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Tugging at the Heart Strings: The Septin Cytoskeleton in Heart Development and Disease by Moore, Kelsey, Moore, Reece, Wang, Christina, Norris, Russell A

“…Septin genes were originally identified in budding yeast in 1971. Since their original discovery, at least 13 mammalian genes have now been found, which give…”
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Histopathological insights into mitral valve prolapse-induced fibrosis by Dieterlen, Maja-Theresa, Klaeske, Kristin, Spampinato, Ricardo, Marin-Cuartas, Mateo, Wiesner, Karoline, Morningstar, Jordan, Norris, Russell A, Melnitchouk, Serguei, Levine, Robert A, van Kampen, Antonia, Borger, Michael A

“…Mitral valve prolapse (MVP) is a cardiac valve disease that not only affects the mitral valve (MV), provoking mitral regurgitation, but also leads to…”
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