Search Results - "Norris, Peter A A"

Viper venoms drive the macrophages and hepatocytes to sequester and clear platelets: novel mechanism and therapeutic strategy for venom-induced thrombocytopenia by Shen, Chuanbin, Liu, Ming, Mackeigan, Daniel Thomas, Chen, Zi Yan, Chen, Pingguo, Karakas, Danielle, Li, June, Norris, Peter A. A., Li, Jiayao, Deng, Yanling, Long, Chengbo, Lai, Ren, Ni, Heyu

“…Venomous snakebites cause clinical manifestations that range from local to systemic and are considered a significant global health challenge. Persistent or…”
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FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia by Norris, Peter A A, Segel, George B, Burack, W Richard, Sachs, Ulrich J, Lissenberg-Thunnissen, Suzanne N, Vidarsson, Gestur, Bayat, Behnaz, Cserti-Gazdewich, Christine M, Callum, Jeannie, Lin, Yulia, Branch, Donald, Kapur, Rick, Semple, John W, Lazarus, Alan H

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Glycoprotein V is a relevant immune target in patients with immune thrombocytopenia by Vollenberg, Richard, Jouni, Rabie, Norris, Peter A A, Burg-Roderfeld, Monika, Cooper, Nina, Rummel, Mathias J, Bein, Gregor, Marini, Irene, Bayat, Behnaz, Burack, Richard, Lazarus, Alan H, Bakchoul, Tamam, Sachs, Ulrich J

“…Platelet autoantibody-induced platelet clearance represents a major pathomechanism in immune thrombocytopenia (ITP). There is growing evidence for clinical…”
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New insights into IVIg mechanisms and alternatives in autoimmune and inflammatory diseases by Norris, Peter A.A., Kaur, Gurleen, Lazarus, Alan H.

“…PURPOSE OF REVIEWIntravenous immunoglobulin (IVIg) is an effective treatment for an increasing number of autoimmune and inflammatory conditions. However, IVIg…”
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Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fcγ receptor inhibition by Norris, Peter A.A., Kaur, Gurleen, Khan, Ramsha, Zhu, Guangheng, Ni, Heyu, Lazarus, Alan H.

“…Monoclonal immunoglobulin G (IgG) antibodies to CD44 (anti-CD44) are anti-inflammatory in numerous murine autoimmune models, but the mechanisms are poorly…”
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Trogocytosis drives red blood cell antigen loss in association with antibody-mediated immune suppression by Cruz-Leal, Yoelys, Norris, Peter A. A., Gil Gonzalez, Lazaro, Marjoram, Danielle, Wabnitz, Hanna, Shan, Yuexin, Lazarus, Alan H.

“…•AMIS-inducing antibodies trigger in vivo RBC antigen and membrane loss independent of clearance.•AMIS-inducing antibodies, including anti-D, trigger in vitro…”
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Inhibition of platelet phagocytosis as an in vitro predictor for therapeutic potential of RBC antibodies in murine ITP by Khan, Ramsha, Menard, Melissa, Jen, Chao-Ching, Chen, Xi, Norris, Peter A.A., Lazarus, Alan H.

“…Polyclonal anti-D is a first-line therapy for immune thrombocytopenia (ITP). Monoclonal antibodies are desirable alternatives, but none have yet proven…”
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Serum from half of patients with immune thrombocytopenia trigger macrophage phagocytosis of platelets by Norris, Peter A A, Tawhidi, Zoya, Sachs, Ulrich J, Cserti-Gazdewich, Christine M, Lin, Yulia, Callum, Jeannie, Gil Gonzalez, Lazaro, Shan, Yuexin, Branch, Donald R, Lazarus, Alan H

“…Humoral antiplatelet factors, such as autoantibodies, are thought to primarily clear platelets by triggering macrophage phagocytosis in immune thrombocytopenia…”
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Human Fc gamma receptor IIIA blockade inhibits platelet destruction in a humanized murine model of ITP by Gil Gonzalez, Lazaro, Won, Kevin D., Tawhidi, Zoya, Cummins, Emma, Cruz-Leal, Yoelys, Tundidor Cabado, Yaima, Sachs, Ulrich J., Norris, Peter A. A., Shan, Yuexin, Bhakta, Varsha, Li, Janessa, Samudio, Ismael, Silva-Moreno, Begonia, Cerna-Portillo, Liza, Pavon Oro, Alequis, Bergqvist, Peter, Chan, Patrick, Moorehead, Amy, Sholzberg, Michelle, Sheffield, William P., Lazarus, Alan H.

“…•Human FcγRIII monovalent blocking as a 1-armed antibody or albumin fusion protein are effective in a humanized model of ITP.•The monovalent albumin fusion…”
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Antibodies Against Macrophage CD44 Protect Platelets from FcγR-Mediated Phagocytosis: A Potential Mechanism for CD44 Antibody Amelioration of Murine Immune Thrombocytopenia by Norris, Peter A A, Wang, Yawen, Zhu, Guangheng, Wang, Lin, Huo, Ming, Fairn, Gregory D, Ni, Heyu, Lazarus, Alan H

“…CD44 is a transmembrane protein that is widely expressed on leukocytes and other cell types. CD44 is the major receptor for hyaluronan, and CD44-hyaluronan…”
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Targeting β3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone by Stratton, Tyler W., Zhu, Guangheng, Wang, Yiming, Chen, Pingguo, Neves, Miguel A.D., Gallant, Reid C., Norris, Peter A.A., Freedman, John J., Ni, Heyu

“…Integrin αIIbβ3 plays key roles in thrombosis and hemostasis primarily through mediating platelet adhesion and aggregation. We recently reported that the…”
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Fcγ Receptors I and III on Splenic Macrophages Mediate GPIIb/IIIa Autoantibody-Dependent Phagocytosis of Platelets in Human Immune Thrombocytopenia by Norris, Peter A.A., Segel, George B., Sachs, Ulrich J, Bayat, Behnaz, Vidarsson, Gestur, Kapur, Rick, Cserti-Gazdewich, Christine M., Callum, Jeannie, Lin, Yulia, Burack, Richard, Semple, John W, Lazarus, Alan H

“…Autoantibody-opsonized platelets in immune thrombocytopenia (ITP) are thought to be destroyed primarily by macrophage Fc gamma receptor (FcγR)-mediated…”
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Anti-Glycoprotein V Autoantibodies in Patients with Immune Thrombocytopenia: Regularly Detectable and Functionally Relevant by Vollenberg, Richard, Jouni, Rabie, Norris, Peter A.A., Burg-Roderfeld, Monika, Cooper, Nina, Rummel, Mathias J, Bein, Gregor, Marini, Irene, Lazarus, Alan H, Bakchoul, Tamam, Sachs, Ulrich J

“…Immune thrombocytopenia (ITP) results from autoimmunization against platelet antigens. Autoantibodies (aabs) are considered to represent a major mechanism of…”
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Serum from half of patients with immune thrombocytopenia triggers macrophage phagocytosis of platelets by Norris, Peter A. A., Tawhidi, Zoya, Sachs, Ulrich J., Cserti-Gazdewich, Christine M., Lin, Yulia, Callum, Jeannie, Gil Gonzalez, Lazaro, Shan, Yuexin, Branch, Donald R., Lazarus, Alan H.

“…•Incubation of ITP serum with normal donor platelets triggered platelet uptake via macrophage phagocytosis for sera from half of the patients with…”
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