Search Results - "Norris, Michael H"

Identification of antiviral antihistamines for COVID-19 repurposing by Reznikov, Leah R., Norris, Michael H., Vashisht, Rohit, Bluhm, Andrew P., Li, Danmeng, Liao, Yan-Shin J., Brown, Ashley, Butte, Atul J., Ostrov, David A.

“…There is an urgent need to identify therapies that prevent SARS-CoV-2 infection and improve the outcome of COVID-19 patients. Although repurposed drugs with…”
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Structural diversity of Burkholderia pseudomallei lipopolysaccharides affects innate immune signaling by Norris, Michael H, Schweizer, Herbert P, Tuanyok, Apichai

“…Burkholderia pseudomallei (Bp) causes the disease melioidosis. The main cause of mortality in this disease is septic shock triggered by the host responding to…”
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Characterization of Bacillus anthracis replication and persistence on environmental substrates associated with wildlife anthrax outbreaks by Jiranantasak, Treenate, Benn, Jamie S, Metrailer, Morgan C, Sawyer, Samantha J, Burns, Madison Q, Bluhm, Andrew P, Blackburn, Jason K, Norris, Michael H

“…Anthrax is a zoonosis caused by the environmentally maintained, spore-forming bacterium Bacillus anthracis , affecting humans, livestock, and wildlife nearly…”
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Single prokaryotic cell isolation and total transcript amplification protocol for transcriptomic analysis by Kang, Yun, McMillan, Ian, Norris, Michael H, Hoang, Tung T

“…This protocol enables amplification of the total transcript of a single prokaryotic cell for in-depth analysis. Laser-capture microdissection is used to…”
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Genome-scale CRISPR screens identify host factors that promote human coronavirus infection by Grodzki, Marco, Bluhm, Andrew P, Schaefer, Moritz, Tagmount, Abderrahmane, Russo, Max, Sobh, Amin, Rafiee, Roya, Vulpe, Chris D, Karst, Stephanie M, Norris, Michael H

“…The COVID-19 pandemic has resulted in 275 million infections and 5.4 million deaths as of December 2021. While effective vaccines are being administered…”
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Laboratory strains of Bacillus anthracis lose their ability to rapidly grow and sporulate compared to wildlife outbreak strains by Norris, Michael H, Zincke, Diansy, Leiser, Owen P, Kreuzer, Helen, Hadfied, Ted L, Blackburn, Jason K

“…Bacillus anthracis is the causative agent of anthrax in animals and humans. The organism lies in a dormant state in the soil until introduced into an animal…”
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Sigma Receptor Ligands Prevent COVID Mortality In Vivo: Implications for Future Therapeutics by Berkowitz, Reed L, Bluhm, Andrew P, Knox, Glenn W, McCurdy, Christopher R, Ostrov, David A, Norris, Michael H

“…The emergence of lethal coronaviruses follows a periodic pattern which suggests a recurring cycle of outbreaks. It remains uncertain as to when the next lethal…”
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An investigation of the seasonal relationships between meteorological factors, water quality, and sporadic cases of Legionnaires’ disease in Washington, DC by Kirpich, Alexander, Shishkin, Aleksandr, Lhewa, Pema, Yang, Chen, von Fricken, Michael E., Norris, Michael H., Weppelmann, Thomas A.

“…Since the discovery of Legionnaires’ disease (LD), limited progress has been made in understanding the epidemiology of sporadic cases of LD. Outbreaks have…”
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Beyond the spore, the exosporium sugar anthrose impacts vegetative Bacillus anthracis gene regulation in cis and trans by Norris, Michael H., Bluhm, Andrew P., Metrailer, Morgan C., Jiranantasak, Treenate, Kirpich, Alexander, Hadfield, Ted, Ponciano, Jose Miguel, Blackburn, Jason K.

“…The Bacillus anthracis exosporium nap is the outermost portion of spore that interacts with the environment and host systems. Changes to this layer have the…”
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Convergent evolution of diverse Bacillus anthracis outbreak strains toward altered surface oligosaccharides that modulate anthrax pathogenesis by Norris, Michael H, Kirpich, Alexander, Bluhm, Andrew P, Zincke, Diansy, Hadfield, Ted, Ponciano, Jose Miguel, Blackburn, Jason K

“…Bacillus anthracis, a spore-forming gram-positive bacterium, causes anthrax. The external surface of the exosporium is coated with glycosylated proteins. The…”
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The Burkholderia pseudomallei intracellular ‘TRANSITome’ by Heacock-Kang, Yun, McMillan, Ian A., Norris, Michael H., Sun, Zhenxin, Zarzycki-Siek, Jan, Bluhm, Andrew P., Cabanas, Darlene, Norton, Robert E., Ketheesan, Natkunam, Miller, Jeff F., Schweizer, Herbert P., Hoang, Tung T.

“…Prokaryotic cell transcriptomics has been limited to mixed or sub-population dynamics and individual cells within heterogeneous populations, which has hampered…”
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Transcript amplification from single bacterium for transcriptome analysis by Kang, Yun, Norris, Michael H, Zarzycki-Siek, Jan, Nierman, William C, Donachie, Stuart P, Hoang, Tung T

“…Total transcript amplification (TTA) from single eukaryotic cells for transcriptome analysis is established, but TTA from a single prokaryotic cell presents…”
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Correction: Convergent evolution of diverse Bacillus anthracis outbreak strains toward altered surface oligosaccharides that modulate anthrax pathogenesis by Norris, Michael H, Kirpich, Alexander, Bluhm, Andrew P, Zincke, Diansy, Hadfield, Ted, Ponciano, Jose Miguel, Blackburn, Jason K

“…[This corrects the article DOI: 10.1371/journal.pbio.3001052.]…”
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An avirulent Burkholderia pseudomallei ∆purM strain with atypical type B LPS: expansion of the toolkit for biosafe studies of melioidosis by Norris, Michael H, Rahman Khan, Md Siddiqur, Schweizer, Herbert P, Tuanyok, Apichai

“…The work was undertaken to expand the tools available for researching Burkholderia pseudomallei (Bp), the etiological agent of the tropical disease…”
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Identification of a PadR-type regulator essential for intracellular pathogenesis of Burkholderia pseudomallei by McMillan, Ian A., Norris, Michael H., Zarzycki-Siek, Jan, Heacock-Kang, Yun, Sun, Zhenxin, Borlee, Bradley R., Hoang, Tung T.

“…Burkholderia pseudomallei ( Bp ) is the causative agent of melioidosis, a disease endemic to the tropics. Melioidosis manifests in various ways ranging from…”
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Nucleotide polymorphism assay for the identification of west African group Bacillus anthracis: a lineage lacking anthrose by Zincke, Diansy, Norris, Michael H, Kurmanov, Berzhan, Hadfield, Ted L, Blackburn, Jason K

“…The exosporium of the anthrax-causing Bacillus anthracis endospores display a tetrasaccharide composed of three rhamnose residues and an unusual sugar termed…”
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TetR-like regulator BP1026B_II1561 controls aromatic amino acid biosynthesis and intracellular pathogenesis in Burkholderia pseudomallei by McMillan, Ian A, Norris, Michael H, Heacock-Kang, Yun, Zarzycki-Siek, Jan, Sun, Zhenxin, Hartney, Brooke A, Filipowska, Liliana K, Islam, M Nurul, Crick, Dean C, Borlee, Bradley R, Hoang, Tung T

“…( ) causes the tropical disease melioidosis that afflicts an estimated 165,000 people each year. is a facultative intracellular pathogen that transits through…”
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Stable, Site-Specific Fluorescent Tagging Constructs Optimized for Burkholderia Species by Norris, Michael H, Kang, Yun, Wilcox, Bruce, Hoang, Tung T

“…Several vectors that facilitate stable fluorescent labeling of Burkholderia pseudomallei and Burkholderia thailandensis were constructed. These vectors…”
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Blocking phosphatidylcholine utilization in Pseudomonas aeruginosa, via mutagenesis of fatty acid, glycerol and choline degradation pathways, confirms the importance of this nutrient source in vivo by Sun, Zhenxin, Kang, Yun, Norris, Michael H, Troyer, Ryan M, Son, Mike S, Schweizer, Herbert P, Dow, Steven W, Hoang, Tung T

“…Pseudomonas aeruginosa can grow to very high-cell-density (HCD) during infection of the cystic fibrosis (CF) lung. Phosphatidylcholine (PC), the major…”
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Multiple FadD acyl-CoA synthetases contribute to differential fatty acid degradation and virulence in Pseudomonas aeruginosa by Kang, Yun, Zarzycki-Siek, Jan, Walton, Chad B, Norris, Michael H, Hoang, Tung T

“…A close interconnection between nutrient metabolism and virulence factor expression contributes to the pathophysiology of Pseudomonas aeruginosa as a…”
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