Search Results - "Norris, D A"

Trends in wound repair: cellular and molecular basis of regenerative therapy using electromagnetic fields by Costin, G-E, Birlea, S A, Norris, D A

“…Chronic ulceration of the leg represents a major, underestimated problem of modern health care, involving physical and cosmetic impairment and social stigma…”
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Novel cutaneous effects of combination chemotherapy with BRAF and MEK inhibitors: a report of two cases by Green, J.S., Norris, D.A., Wisell, J.

“…Summary The discovery that some melanoma tumours harbour mutations in the BRAF gene (e.g. V600E) and the subsequent development of specific BRAF inhibitors…”
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INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma by Yang, N, Leung, E L-H, Liu, C, Li, L, Eguether, T, Jun Yao, X-J, Jones, E C, Norris, D A, Liu, A, Clark, R A, Roop, D R, Pazour, G J, Shroyer, K R, Chen, J

“…Inturned (INTU), a cilia and planar polarity effector, performs prominent ciliogenic functions during morphogenesis, such as in the skin. INTU is expressed in…”
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Mercury in United Kingdom topsoils; concentrations, pools, and Critical Limit exceedances by Tipping, E., Poskitt, J.M., Lawlor, A.J., Wadsworth, R.A., Norris, D.A., Hall, J.R.

“…The median total mercury concentration in 898 UK rural topsoils, sampled between 1998 and 2008, was 0.095 μg g −1. Approximate adjustment for unreactive metal…”
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Whole recombinant yeast vaccine induces antitumor immunity and improves survival in a genetically engineered mouse model of melanoma by Tanaka, A, Jensen, J D, Prado, R, Riemann, H, Shellman, Y G, Norris, D A, Chin, L, Yee, C, Fujita, M

“…Malignant melanoma is one of the deadliest forms of skin cancer and its incidence is expected to rise over the next two decades. At present, there are no…”
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Dermatology training across the globe, part II: a summary of the literature by Ashack, K.A., Burton, K.A., Barber, C., St. Claire, K., Mounessa, J., Dunnick, C.A., Norris, D.A., Dellavalle, R.P.

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Long-term mercury dynamics in UK soils by Tipping, E., Wadsworth, R.A., Norris, D.A., Hall, J.R., Ilyin, I.

“…A model assuming first-order losses by evasion and leaching was used to evaluate Hg dynamics in UK soils since 1850. Temporal deposition patterns of Hg were…”
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NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma by Zhai, Z, Liu, W, Kaur, M, Luo, Y, Domenico, J, Samson, J M, Shellman, Y G, Norris, D A, Dinarello, C A, Spritz, R A, Fujita, M

“…Inflammasomes are mediators of inflammation, and constitutively activated NLRP3 inflammasomes have been linked to interleukin-1β (IL-1β)-mediated tumorigenesis…”
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Development of predictive pharmacokinetic simulation models for drug discovery by Norris, D.A., Leesman, G.D., Sinko, P.J., Grass, G.M.

“…As discovery chemistry produces increased numbers of potential drug compounds, the use of ADME (absorption, distribution, metabolism, and excretion) properties…”
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Keratinocytes from patients with lupus erythematosus show enhanced cytotoxicity to ultraviolet radiation and to antibody‐mediated cytotoxicity by Furukawa, F., Itoh, T., Wakita, H., Yagi, H., Tokura, Y., Norris, D. A., Takigawa, M.

“…Keratinocyte cytotoxicity is an important component of the immunopathology of photosensitive lupus erythematosus, and antibody‐dependent cell‐mediated…”
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Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells by MAKHEY, V. D, GUO, A, NORRIS, D. A, PEIDI HU, JIANSHENG YAN, SINKO, P. J

“…The aim of the present study was to investigate the transport kinetics of intestinal secretory processes in the jejunum, ileum and colon of rats and humans and…”
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Complex hydrological controls on wet dune slacks: the importance of local variability by Jones, M L M, Reynolds, B, Brittain, S A, Norris, D A, Rhind, P M, Jones, R E

“…Dune slacks are a species-rich habitat controlled largely by water chemistry and fluctuations in groundwater. Changes in water chemistry and water table level…”
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Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis : evidence for a new group of allergens by LEUNG, D. Y. M, HARBECK, R, BINA, P, REISER, R. F, YANG, E, NORRIS, D. A, HANIFIN, J. M, SAMPSON, H. A

“…In the current study, we investigated whether Staphylococcus aureus grown from affected skin of atopic dermatitis (AD) patients secreted identifiable toxins…”
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The role of superantigens in human diseases: therapeutic implications for the treatment of skin diseases by Leung, D Y, Hauk, P, Strickland, I, Travers, J B, Norris, D A

“…Although it is well established that immune mechanisms contribute to the pathogenesis of chronic inflammatory skin diseases such as atopic dermatitis (AD) and…”
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Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation by Birlea, S A, Costin, G-E, Norris, D A

“…The active metabolite of vitamin D3 - 1,25-(OH)2D3 - exerts most of its physiological and pharmacological actions through its nuclear receptor (VDR),…”
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A Potential Role for Superantigens in the Pathogenesis of Psoriasis by Leung, Donald Y.M., Walsh, Patrick, Giorno, Ralph, Norris, David A.

“…Psoriasis is a complex inflammatory skin disease in which local vascular changes, T-cell activation, abnormal keratinocyte proliferation and differentiation,…”
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Interleukin-1 Receptor antagonist Production by Human Keratinocytes by Bigler, Carl F, Norris, David A, Weston, William L, Arend, William P

“…Human keratinocytes produce biologically active pro–IL-Iα and inactive pro-IL-1β with most protein remaining intracellular. IL-1 receptor antagonist (IL-1ra)…”
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The global burden of disease associated with alopecia areata by Karimkhani, C., Boyers, L.N., Naghavi, M., Coffeng, L.E., Lott, J.P., Wulf, S., Hay, R., Williams, H.C., Weinstock, M.A., Norton, S.A., Armstrong, A.W., Dunnick, C.A., Norris, D.A., Dellavalle, R.P.

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RAS Mutations in Human Melanoma: A Marker of Malignant Progression by Ball, Nigel J., Yohn, Joseph J., Morelli, Joseph G., Norris, David A., Golitz, Loren E., Hoeffler, James P.

“…In this study we address whether there is an association between ras mutations and disease progression in malignant melanoma. DNA was extracted from 100…”
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Nitrogen concentrations in mosses indicate the spatial distribution of atmospheric nitrogen deposition in Europe by Harmens, H., Norris, D.A., Cooper, D.M., Mills, G., Steinnes, E., Kubin, E., Thöni, L., Aboal, J.R., Alber, R., Carballeira, A., Coşkun, M., De Temmerman, L., Frolova, M., González-Miqueo, L., Jeran, Z., Leblond, S., Liiv, S., Maňkovská, B., Pesch, R., Poikolainen, J., Rühling, Å., Santamaria, J.M., Simonèiè, P., Schröder, W., Suchara, I., Yurukova, L., Zechmeister, H.G.

“…In 2005/6, nearly 3000 moss samples from (semi-)natural location across 16 European countries were collected for nitrogen analysis. The lowest total nitrogen…”
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