Search Results - "Norris, Beverly"

Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts by Patil, Satish, Lis, Lev G, Schumacher, Robert J, Norris, Beverly J, Morgan, Monique L, Cuellar, Rebecca A. D, Blazar, Bruce R, Suryanarayanan, Raj, Gurvich, Vadim J, Georg, Gunda I

“…A disodium phosphonooxymethyl prodrug of the antitumor agent triptolide was prepared from the natural product in three steps (39% yield) and displayed…”
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A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats-an Investigational Therapy for ARDS by Flory, Craig M, Norris, Beverly J, Larson, Nicole A, Coicou, Lia G, Koniar, Brenda L, Mysz, Margaret A, Rich, Timothy P, Ingbar, David H, Schumacher, Robert J

“…Acute respiratory distress syndrome (ARDS) is a severe, life-threatening form of respiratory failure characterized by pulmonary edema, inflammation, and…”
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Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity by Oppegard, Lisa M., Delgado, Justine L., Kulkarni, Chaitanya A., Towle, Tyrell R., Hart, Delaney E., Williams, Bridget P., Lentz, Sarah R. C., Norris, Beverly J., Flory, Craig M., Schumacher, Robert J., Murry, Daryl J., Kerns, Robert J., Hiasa, Hiroshi

“…Summary Fluoroquinolone-class agents selectively target the bacterial type IIA topoisomerases DNA gyrase and topoisomerase IV, with a few exceptions that…”
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Abstract LB078: Hexyl-(cuban-1-yl-methyl)-biguanide (HCB) inhibits hormone therapy resistant breast cancer cells, in part by Inhibiting CYP3A4 arachidonic acid epoxygenase activity by Guo, Zhijun, Lei, Jianxun, Hong, Kwon Ho, Norris, Beverly, Flory, Craig M., Jayaraman, Swaathi, McDermott, Connor, Ambrose, Elizabeth, Sevrioukova, Irina, Poulos, Tom, Denisov, Ilia, Sliga, Stephen, Schumacher, Robert J., Georg, Gunda I., Hawse, John R., Goetz, Matthew P., Potter, David A.

“…Abstract Introduction: Small molecule therapeutics of estrogen receptor-positive/HER2-negative breast cancer remains an area of active investigation where…”
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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria by Guo, Zhijun, Sevrioukova, Irina F, Denisov, Ilia G, Zhang, Xia, Chiu, Ting-Lan, Thomas, Dafydd G, Hanse, Eric A, Cuellar, Rebecca A D, Grinkova, Yelena V, Langenfeld, Vanessa Wankhede, Swedien, Daniel S, Stamschror, Justin D, Alvarez, Juan, Luna, Fernando, Galván, Adela, Bae, Young Kyung, Wulfkuhle, Julia D, Gallagher, Rosa I, Petricoin, Rd, Emanuel F, Norris, Beverly, Flory, Craig M, Schumacher, Robert J, O'Sullivan, M Gerard, Cao, Qing, Chu, Haitao, Lipscomb, John D, Atkins, William M, Gupta, Kalpna, Kelekar, Ameeta, Blair, Ian A, Capdevila, Jorge H, Falck, John R, Sligar, Stephen G, Poulos, Thomas L, Georg, Gunda I, Ambrose, Elizabeth, Potter, David A

“…The mechanisms by which cancer cell-intrinsic CYP monooxygenases promote tumor progression are largely unknown. CYP3A4 was unexpectedly associated with breast…”
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Abstract LB102: Hexyl-(cuban-1-yl-methyl)-biguanide (HCB) suppresses N-glycosylation of immune checkpoint proteins B7-H3 and B7-H4, reverses tumor hypoxia, decreases intratumoral regulatory T cells, and increases intratumoral CD8+ T cells in the ovarian dependent ER+HER2- SSM2ucd mammary cancer allograft model by Guo, Zhijun, Lei, Jianxun, Venkatesh, Hrishi, Owen, David, Bass, Adam, Cannon, Christine, McCarra, Joshua, Koniar, Brenda, Flory, Craig, Norris, Beverly, Schumacher, Robert J., Jayaraman, Swaathi, Hawse, John, Antonarakis, Emmanuel S., Petricoin, Emanuel F., Wulfkuhle, Julia, Cardiff, Robert D., Ambrose, Elizabeth A., Georg, Gunda I., Schwertfeger, Kaylee L., Farrar, Michael A., Croix, Brad St, Goetz, Matthew P., Potter, David A.

“…Abstract Introduction: Immune checkpoint blockade (ICB) has clinical activity in triple negative breast cancer (TNBC) but is less effective in the ER+HER2-…”
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Abstract 44: Hexyl-benzyl-biguanide (HBB) potently and selectively inhibits CYP3A4 epoxygenase activity and inhibits EET stabilization of mitochondrial respiration in ER+HER2- breast cancer cells, inducing glycolysis and pyruvate biosynthesis by Guo, Zhijun, Sevrioukova, Irina, Hanse, Eric, Zhang, Xia, Denisov, Ilia, Chiu, Ting-Lan, Cuellar, Rebecca, Torres, Christian, Wulfkuhle, Julia, Petricoin, Emanuel, Cao, Qing, Chu, Haitao, Norris, Beverly, Schumacher, Robert, Kelekar, Ameeta, Blair, Ian, Capdevila, Jorge, Falck, John, Poulos, Thomas, Sligar, Steven, Georg, Gunda, Amin, Elizabeth, Potter, David A.

“…Abstract Cytochrome P450 3A4 (CYP3A4) promotes ER+HER2- breast cancer cell proliferation and survival, in part, by biosynthesis of epoxyeicosatrienoic acids…”
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Abstract 82: CYP3A4 promotes mammary carcinoma angiogenesis in a cell iIntrinsic fashion by Guo, Zhijun, Norris, Beverly, Henriksen, Jonathan, Morgan, Monique, Maher, Michael, Schumacher, Robert, Bliss, Robin, Chu, Haitao, Gupta, Kalpna, Schmechel, Stephen, Potter, David

“…Abstract Cytochrome P450 3A4 (CYP3A4) has been recently been implicated in breast cancer cell growth and survival, but the role of cell intrinsic CYP3A4 in…”
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Abstract 3568: CYP3A4 epoxygenase activity mediates ER+ mammary tumor growth and angiogenesis, in part, through EET biosynthesis and is inhibited by biguanides by Guo, Zhijun, Sevrioukova, Irina F., Hanse, Eric, Denisov, Ilia, Zhang, Xia, Chiu, Ting-Lan, Swedien, Daniel, Stamschror, Justin, Alvarez, Juan, Ortiz, William Marerro, Morgan, Monique, Maher, Michael, Chavez, Kathryn J., Thomas, Dafydd, Bae, Young Kyung, Henriksen, Jonathan, Norris, Beverly, Schumacher, Robert J., Wang, Henry, Bliss, Robin, Chu, Haitao, Cuellar, Rebecca, Poulos, Thomas L., Sligar, Stephen G., Atkins, William, Schmechel, Stephen, Capdevila, Jorge, Falck, John, Blair, Ian, Jones, Jeffrey P., Georg, Gunda, Gupta, Kalpna, Kelekar, Ameeta, Amin, Elizabeth, Potter, David A.

“…Abstract While cytochrome P450 enzymes (CYPs) are implicated in tumor angiogenesis through biosynthesis of epoxyeicosatrienoic acids (EETs), little is known…”
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Abstract 2689: Breast cancer inhibition by a novel and potent biguanide, N1-hexyl-N5-benzyl-biguanide by Guo, Zhijun, Chavez, Kathryn J., Alvarez, Juan, Zhang, Xia, Norris, Beverly, Maher, Michael, Morgan, Monique, Schumacher, Robert J., Cuellar, Rebecca, Sevrioukova, Irina F., Poulos, Thomas L., Denisov, Ilia, Sligar, Stephen G., Gupta, Kalpna, Blair, Ian A., Capdevila, Jorge, Kelekar, Ameeta, Amin, Elizabeth, Georg, Gunda, Potter, David A.

“…Abstract Metformin is a widely used biguanide diabetes drug that is associated with decreased breast cancer risk and is currently being studied for treatment…”
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519 - Robust Progenitor T-Cell Production From Human Hematopoietic Progenitor Cell Expanded with Stemregenin-1 by Stefanski, Heather, Singh, Jastaranpreet, Norris, Beverly, Schumacher, Robert, Wagner, John E., Blazar, Bruce R., Zuniga-Pflucker, Juan Carlos

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Robust Progenitor T-Cell Production From Human Hematopoietic Progenitor Cell Expanded with Stemregenin-1 by Stefanski, Heather, Singh, Jastaranpreet, Norris, Beverly, Schumacher, Robert, Wagner, John E., Blazar, Bruce R., Zuniga-Pflucker, Juan Carlos

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A framework for evaluating safety in design by Norris, Beverly

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Enzymatic assays for 2-deoxyglucose and 2-deoxyglucose 6-phosphate by Chi, M M, Pusateri, M E, Carter, J G, Norris, B J, McDougal, Jr, D B, Lowry, O H

“…Methods for 2-deoxyglucose (2-DG) and 2-deoxyglucose 6-phosphate (DG6P) are described which are based on the fact that DG6P is oxidized by glucose-6-phosphate…”
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'Dystrophic' lipid myopathy in two sisters by Carroll, J E, Brooke, M H, Villadiego, A, Norris, B J, Trefz, J I

“…Two sisters with progressive myopathy demonstrated microscopic and biochemical evidence of lipid storage in skeletal muscle. Their muscle biopsy specimens…”
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Suitability of Fetal Tissues From Spontaneous Abortions and From Ectopic Pregnancies for Transplantation by Branch, D. Ware, Ducat, Lee, Fantel, Alan, Low, Walter C, Zhou, Feng C, Dayton, Delbert H, Gill, Thomas J, Bledsoe, Sharon, Chiang, Yung-Hsiao, Chong, Sonny K, Hainline, Bryan E, Heifetz, Stephen A, Kahlenbeck, Debra, Low, Qinyuan, Padilla, Lillie-Mae, Palmer, Catherine, Peavy, Daniel, Blazer, Bruce, Blount, Jeff, Christianson, Judy, Chrysler, Gayl, Conrad, John, Coultrip, Laura, D'Ascoli, Peter, Eastlund, Ted, Forbes, Jeanne, Gasser, Tom, Hirschel, Mark, Kearney, Warren, Kondoh, Takeshi, Li, Ying-jie, Maynard, Sandy, Miller, Jeff, Norris, Beverly, Okagaki, Takashi, Peterson, Anne, Pundt, Lisa, Sengupta, Ranjita, Verfaillie, Catherine, Virnig, Beth, Weese, Kathy, Williams, Preston, Feil, Kelly, Hayek, Alberto, Lee, Virginia, McCormack, Michael K, McMorris, F. Arthur, Shen-Schwarz, Susan, Trojanowski, John Q, Byrne, Janice L. B, Ward, Kenneth, Hillier, Sharon, Hogan, Molly, Kapur, Raj, Krohn, Marijane, Leppig, Kathy, Mason, Julie, Mueller, Beth, Newman-Gage, Helen, Norwood, Thomas, Rigley, Ted, Thwin, Soe Soe, Vick, Tara

“…Objective.—To assess the potential availability and utility of fetal tissues obtained from spontaneous abortions and from ectopic pregnancies for human…”
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Effect of microgravity on metabolic enzymes of individual muscle fibers by Manchester, J K, Chi, M M, Norris, B, Ferrier, B, Krasnov, I, Nemeth, P M, McDougal, Jr, D B, Lowry, O H

“…Eleven enzymes were measured in individual fibers of soleus and tibialis anterior (TA) muscles from two flight and two control (synchronous) animals. There…”
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Muscle mitochondria from patients with Duchenne muscular dystrophy have a normal beta oxidation, but an impaired oxidative phosphorylation by Carroll, James E., Norris, Beverly J., Brooke, Michael H.

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Strategies to Improve Reading Comprehension by Griffin, Beverly Norris

“…Discusses how directed reading activities and vocabulary guides can be used in an English classroom to help improve students' reading comprehension. (HOD)…”
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A Three-Phase Procedure for Selecting Textbooks: Less Than the Best but Better Than Usual by Griffin, Beverly Norris

“…A three-part review process is proposed as an aid to textbook selection for college courses. After an introductory discussion of the importance of developing…”
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