Search Results - "Norona, Frances E"

Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits by Snider, Kaitlin H., Dziema, Heather, Aten, Sydney, Loeser, Jacob, Norona, Frances E., Hoyt, Kari, Obrietan, Karl

“…•Development of a mouse model with disruption of the clock gene Bmal1 in forebrain neurons.•SCN function is not altered in Bmal1 forebrain knockout mice.•Bmal1…”
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Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock by Sakamoto, Kensuke, Norona, Frances E, Alzate-Correa, Diego, Scarberry, Daniel, Hoyt, Kari R, Obrietan, Karl

“…The CREB/CRE transcriptional pathway has been implicated in circadian clock timing and light-evoked clock resetting. To date, much of the work on CREB in…”
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C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci by Mizielinska, Sarah, Lashley, Tammaryn, Norona, Frances E., Clayton, Emma L., Ridler, Charlotte E., Fratta, Pietro, Isaacs, Adrian M.

“…An expanded GGGGCC repeat in a non-coding region of the C9orf72 gene is a common cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral…”
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The integration site of the APP transgene in the J20 mouse model of Alzheimer's disease by Tosh, Justin L, Rickman, Matthew, Rhymes, Ellie, Norona, Frances E, Clayton, Emma, Mucke, Lennart, Isaacs, Adrian M, Fisher, Elizabeth M C, Wiseman, Frances K

“…Transgenic animal models are a widely used and powerful tool to investigate human disease and develop therapeutic interventions. Making a transgenic mouse…”
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C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins by Mizielinska, Sarah, Grönke, Sebastian, Niccoli, Teresa, Ridler, Charlotte E., Clayton, Emma L., Devoy, Anny, Moens, Thomas, Norona, Frances E., Woollacott, Ione O. C., Pietrzyk, Julian, Cleverley, Karen, Nicoll, Andrew J., Pickering-Brown, Stuart, Dols, Jacqueline, Cabecinha, Melissa, Hendrich, Oliver, Fratta, Pietro, Fisher, Elizabeth M. C., Partridge, Linda, Isaacs, Adrian M.

“…An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is…”
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The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease by Tosh, Justin L., Rickman, Matthew, Rhymes, Ellie, Norona, Frances E., Clayton, Emma, Mucke, Lennart, Isaacs, Adrian M., Fisher, Elizabeth M.C., Wiseman, Frances K.

“…Background: Transgenic animal models are a widely used and powerful tool to investigate human disease and develop therapeutic interventions. Making a…”
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Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown by Clayton, Emma L, Milioto, Carmelo, Muralidharan, Bhavana, Norona, Frances E, Edgar, James R, Soriano, Armand, Jafar-nejad, Paymaan, Rigo, Frank, Collinge, John, Isaacs, Adrian M

“…See Bechek and Gitler (doi:10.1093/brain/awy294) for a scientific commentary on this article. Mutations in the endosome-associated protein CHMP2B cause…”
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Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology by Clayton, Emma L., Mizielinska, Sarah, Edgar, James R., Nielsen, Troels Tolstrup, Marshall, Sarah, Norona, Frances E., Robbins, Miranda, Damirji, Hana, Holm, Ida E., Johannsen, Peter, Nielsen, Jørgen E., Asante, Emmanuel A., Collinge, John, Isaacs, Adrian M.

“…Mutations in the charged multivesicular body protein 2B ( CHMP2B ) cause frontotemporal dementia (FTD). We report that mice which express FTD-causative mutant…”
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