Search Results - "Normandin, Karine"

Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry by Kachaner, David, Garrido, Damien, Mehsen, Haytham, Normandin, Karine, Lavoie, Hugo, Archambault, Vincent

“…The Polo kinase is a master regulator of mitosis and cytokinesis conserved from yeasts to humans. Polo is composed of an N-term kinase domain (KD) and a C-term…”
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Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations by Normandin, Karine, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bernard, Alexandre, Bourouh, Mohammed, Bertomeu, Thierry, Tyers, Mike, Archambault, Vincent

“…Polo-like kinase 1 (PLK1) is a serine/threonine kinase required for mitosis and cytokinesis. As cancer cells are often hypersensitive to partial PLK1…”
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Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis by Kachaner, David, Pinson, Xavier, El Kadhi, Khaled Ben, Normandin, Karine, Talje, Lama, Lavoie, Hugo, Lépine, Guillaume, Carréno, Sébastien, Kwok, Benjamin H, Hickson, Gilles R, Archambault, Vincent

“…Drosophila melanogaster Polo and its human orthologue Polo-like kinase 1 fulfill essential roles during cell division. Members of the Polo-like kinase (Plk)…”
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Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression by Wang, Peng, Galan, Jacob A, Normandin, Karine, Bonneil, Éric, Hickson, Gilles R, Roux, Philippe P, Thibault, Pierre, Archambault, Vincent

“…Cell division requires the coordination of critical protein kinases and phosphatases. Greatwall (Gwl) kinase activity inactivates PP2A-B55 at mitotic entry to…”
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Protease inhibitor SERPINA1 expression in epithelial ovarian cancer by Normandin, Karine, Péant, Benjamin, Le Page, Cécile, de Ladurantaye, Manon, Ouellet, Véronique, Tonin, Patricia N, Provencher, Diane M, Mes-Masson, Anne-Marie

“…Epithelial ovarian cancer is the most lethal gynecologic cancer with a 5 years survival rate of 30-40% in patients diagnosed with high-grade invasive disease…”
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Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators by Archambault, Vincent, Normandin, Karine

“…For almost a decade, there has been much interest in the development of chemical inhibitors of Polo-like kinase 1 (Plk1) protein interactions. Plk1 is a master…”
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Immunohistochemical profiling of benign, low malignant potential and low grade serous epithelial ovarian tumors by Ouellet, Véronique, Ling, Tak Hay, Normandin, Karine, Madore, Jason, Lussier, Christian, Barrès, Véronique, Bachvarov, Dimcho, Rancourt, Claudine, Tonin, Patricia N, Provencher, Diane M, Mes-Masson, Anne-Marie

“…Serous epithelial ovarian tumors can be subdivided into benign (BOV), low malignant potential (LMP) or borderline and invasive (TOV) tumors. Although the…”
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Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression by Larouche, Myreille, Kachaner, David, Wang, Peng, Normandin, Karine, Garrido, Damien, Yao, Changfu, Cormier, Maxime, Johansen, Kristen M, Johansen, Jørgen, Archambault, Vincent

“…Mitotic entry involves inhibition of protein phosphatase 2A bound to its B55/Tws regulatory subunit (PP2A-B55/Tws), which dephosphorylates substrates of…”
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Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle by Wang, Peng, Larouche, Myreille, Normandin, Karine, Kachaner, David, Mehsen, Haytham, Emery, Gregory, Archambault, Vincent

“…Entry into mitosis requires the phosphorylation of multiple substrates by cyclin B-Cdk1, while exit from mitosis requires their dephosphorylation, which…”
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Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay by Normandin, Karine, Lavallée, Jean-François, Futter, Marie, Beautrait, Alexandre, Duchaine, Jean, Guiral, Sébastien, Marinier, Anne, Archambault, Vincent

“…Polo-like kinase 1 (Plk1) plays several roles in cell division and it is a recognized cancer drug target. Plk1 levels are elevated in cancer and several types…”
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Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators by Archambault, Vincent, Normandin, Karine

“…For almost a decade, there has been much interest in the development of chemical inhibitors of Polo-like kinase 1 (Plk1) protein interactions. Plk1 is a master…”
Get full text

Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle by Wang, Peng, Larouche, Myreille, Normandin, Karine, Kachaner, David, Mehsen, Haytham, Emery, Gregory, Archambault, Vincent

“…Entry into mitosis requires the phosphorylation of multiple substrates by cyclin B-Cdk1, while exit from mitosis requires their dephosphorylation, which…”
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