Search Results - "Normandin, Erica"

Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies by Duan, Hongying, Chen, Xuejun, Boyington, Jeffrey C., Cheng, Cheng, Zhang, Yi, Jafari, Alexander J., Stephens, Tyler, Tsybovsky, Yaroslav, Kalyuzhniy, Oleksandr, Zhao, Peng, Menis, Sergey, Nason, Martha C., Normandin, Erica, Mukhamedova, Maryam, DeKosky, Brandon J., Wells, Lance, Schief, William R., Tian, Ming, Alt, Frederick W., Kwong, Peter D., Mascola, John R.

“…An important class of HIV-1 broadly neutralizing antibodies, termed the VRC01 class, targets the conserved CD4-binding site (CD4bs) of the envelope…”
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High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection by Normandin, Erica, Rudy, Melissa, Barkas, Nikolaos, Schaffner, Stephen F., Levine, Zoe, Padera, Robert F., Babadi, Mehrtash, Mukerji, Shibani S., Park, Daniel J., MacInnis, Bronwyn L., Siddle, Katherine J., Sabeti, Pardis C., Solomon, Isaac H.

“…SARS-CoV-2 distribution and circulation dynamics are not well understood due to challenges in assessing genomic data from tissue samples. We develop…”
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Functional Profiling of Antibody Immune Repertoires in Convalescent Zika Virus Disease Patients by Fahad, Ahmed S, Timm, Morgan R, Madan, Bharat, Burgomaster, Katherine E, Dowd, Kimberly A, Normandin, Erica, Gutiérrez-González, Matías F, Pennington, Joseph M, De Souza, Matheus Oliveira, Henry, Amy R, Laboune, Farida, Wang, Lingshu, Ambrozak, David R, Gordon, Ingelise J, Douek, Daniel C, Ledgerwood, Julie E, Graham, Barney S, Castilho, Leda R, Pierson, Theodore C, Mascola, John R, DeKosky, Brandon J

“…The re-emergence of Zika virus (ZIKV) caused widespread infections that were linked to Guillain-Barré syndrome in adults and congenital malformation in…”
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Neuropathological Features of Covid-19 by Solomon, Isaac H, Normandin, Erica, Bhattacharyya, Shamik, Mukerji, Shibani S, Keller, Kiana, Ali, Ahya S, Adams, Gordon, Hornick, Jason L, Padera, Robert F, Sabeti, Pardis

“…Eighteen brains of patients who died 0 to 32 days after the onset of symptoms of SARS-CoV-2 infection showed hypoxic–ischemic changes but no encephalitis,…”
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Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events by Lemieux, Jacob E, Siddle, Katherine J, Shaw, Bennett M, Loreth, Christine, Schaffner, Stephen F, Gladden-Young, Adrianne, Adams, Gordon, Fink, Timelia, Tomkins-Tinch, Christopher H, Krasilnikova, Lydia A, DeRuff, Katherine C, Rudy, Melissa, Bauer, Matthew R, Lagerborg, Kim A, Normandin, Erica, Chapman, Sinéad B, Reilly, Steven K, Anahtar, Melis N, Lin, Aaron E, Carter, Amber, Myhrvold, Cameron, Kemball, Molly E, Chaluvadi, Sushma, Cusick, Caroline, Flowers, Katelyn, Neumann, Anna, Cerrato, Felecia, Farhat, Maha, Slater, Damien, Harris, Jason B, Branda, John A, Hooper, David, Gaeta, Jessie M, Baggett, Travis P, O'Connell, James, Gnirke, Andreas, Lieberman, Tami D, Philippakis, Anthony, Burns, Meagan, Brown, Catherine M, Luban, Jeremy, Ryan, Edward T, Turbett, Sarah E, LaRocque, Regina C, Hanage, William P, Gallagher, Glen R, Madoff, Lawrence C, Smole, Sandra, Pierce, Virginia M, Rosenberg, Eric, Sabeti, Pardis C, Park, Daniel J, MacInnis, Bronwyn L

“…Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous…”
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Developing Experimental and Computational Approaches to Characterize Viral Distribution, Spread, and Variant Emergence by Normandin, Erica

“…Many viral mutations that impact human pathogenicity arise over the course of disease, yet intrahost viral dynamics remain poorly characterized. Mutations that…”
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Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles by Brown, Eric P., Dowell, Karen G., Boesch, Austin W., Normandin, Erica, Mahan, Alison E., Chu, Thach, Barouch, Dan H., Bailey-Kellogg, Chris, Alter, Galit, Ackerman, Margaret E.

“…Antibodies are widely considered to be a frequent primary and often mechanistic correlate of protection of approved vaccines; thus evaluating the antibody…”
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Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires by Tian, Ming, Cheng, Cheng, Chen, Xuejun, Duan, Hongying, Cheng, Hwei-Ling, Dao, Mai, Sheng, Zizhang, Kimble, Michael, Wang, Lingshu, Lin, Sherry, Schmidt, Stephen D., Du, Zhou, Joyce, M. Gordon, Chen, Yiwei, DeKosky, Brandon J., Chen, Yimin, Normandin, Erica, Cantor, Elizabeth, Chen, Rita E., Doria-Rose, Nicole A., Zhang, Yi, Shi, Wei, Kong, Wing-Pui, Choe, Misook, Henry, Amy R., Laboune, Farida, Georgiev, Ivelin S., Huang, Pei-Yi, Jain, Suvi, McGuire, Andrew T., Georgeson, Eric, Menis, Sergey, Douek, Daniel C., Schief, William R., Stamatatos, Leonidas, Kwong, Peter D., Shapiro, Lawrence, Haynes, Barton F., Mascola, John R., Alt, Frederick W.

“…The design of immunogens that elicit broadly reactive neutralizing antibodies (bnAbs) has been a major obstacle to HIV-1 vaccine development. One approach to…”
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Functional interrogation and mining of natively paired human V H :V L antibody repertoires by Wang, Bo, DeKosky, Brandon J, Timm, Morgan R, Lee, Jiwon, Normandin, Erica, Misasi, John, Kong, Rui, McDaniel, Jonathan R, Delidakis, George, Leigh, Kendra E, Niezold, Thomas, Choi, Chang W, Viox, Elise G, Fahad, Ahmed, Cagigi, Alberto, Ploquin, Aurélie, Leung, Kwanyee, Yang, Eun Sung, Kong, Wing-Pui, Voss, William N, Schmidt, Aaron G, Moody, M Anthony, Ambrozak, David R, Henry, Amy R, Laboune, Farida, Ledgerwood, Julie E, Graham, Barney S, Connors, Mark, Douek, Daniel C, Sullivan, Nancy J, Ellington, Andrew D, Mascola, John R, Georgiou, George

“…We present a technology to screen millions of B cells for natively paired human antibody repertoires. Libraries of natively paired, variable region heavy and…”
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Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19 by Conklin, John, Frosch, Matthew P., Mukerji, Shibani S., Rapalino, Otto, Maher, Mary D., Schaefer, Pamela W., Lev, Michael H., Gonzalez, R.G., Das, Sudeshna, Champion, Samantha N., Magdamo, Colin, Sen, Pritha, Harrold, G. Kyle, Alabsi, Haitham, Normandin, Erica, Shaw, Bennett, Lemieux, Jacob E., Sabeti, Pardis C., Branda, John A., Brown, Emery N., Westover, M. Brandon, Huang, Susie Y., Edlow, Brian L.

“…We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive…”
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Computational Optics Enables Breast Cancer Profiling in Point-of-Care Settings by Min, Jouha, Im, Hyungsoon, Allen, Matthew, McFarland, Phillip J, Degani, Ismail, Yu, Hojeong, Normandin, Erica, Pathania, Divya, Patel, Jaymin M, Castro, Cesar M, Weissleder, Ralph, Lee, Hakho

“…The global burden of cancer, severe diagnostic bottlenecks in underserved regions, and underfunded health care systems are fueling the need for inexpensive,…”
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Neuropathological Features of COVID-19 (4641) by Normandin, Erica, Bhattacharyya, Shamik, Mukerji, Shibani, Keller, Kiana, Ali, Ahya, Adams, Gordon, Hornick, Jason, Padera, Robert, Sabeti, Pardis, Solomon, Isaac H.

“…Abstract only…”
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Neuropathological features of SARS-CoV-2 delta and omicron variants by Normandin, Erica, Valizadeh, Navid, Rudmann, Emily A, Uddin, Rockib, Dobbins, Sabrina T, MacInnis, Bronwyn L, Padera, Robert F, Siddle, Katherine J, Lemieux, Jacob E, Sabeti, Pardis C, Mukerji, Shibani S, Solomon, Isaac H

“…Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continually evolving resulting in variants with increased transmissibility, more…”
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Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV by Brown, Eric P., Weiner, Joshua A., Lin, Shu, Natarajan, Harini, Normandin, Erica, Barouch, Dan H., Alter, Galit, Sarzotti-Kelsoe, Marcella, Ackerman, Margaret E.

“…The Fc Array is a multiplexed assay that assesses the Fc domain characteristics of antigen-specific antibodies with the potential to evaluate up to 500 antigen…”
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Intrathecal inflammatory responses in the absence of SARS-CoV-2 nucleic acid in the CSF of COVID-19 hospitalized patients by Normandin, Erica, Holroyd, Kathryn B., Collens, Sarah I., Shaw, Bennett M., Siddle, Katherine J., Adams, Gordon, Rudy, Melissa, Solomon, Isaac H., Anahtar, Melis N., Lemieux, Jacob E., Trombetta, Bianca A., Kivisakk, Pia, Arnold, Steven E., Rapalino, Otto, Piantadosi, Anne L., Sen, Pritha, Rosenberg, Eric S., Branda, John, Sabeti, Pardis C., Mukerji, Shibani S.

“…Little is known about CSF profiles in patients with acute COVID-19 infection and neurological symptoms. Here, CSF was tested for SARS-CoV-2 RNA and…”
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Intrathecal inflammatory responses in the absence of SARS-CoV-2 nucleic acid in the CSF of COVID-19 hospitalized patients (S18.004) by Normandin, Erica, Holroyd, Kathryn, Collens, Sarah, Shaw, Bennett, Siddle, Katherine, Adams, Gordon, Rudy, Melissa, Solomon, Isaac H., Anahatar, Melis, Lemieux, Jacob, Trombetta, Bianca, Webb, Pia K., Arnold, Steven, Rapalino, Otto, Piantadosi, Anne, Sen, Pritha, Rosenberg, Eric, Branda, John, Sabeti, Pardis, Mukerji, Shibani

“…Abstract only…”
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Highly parallel characterization of IgG Fc binding interactions by Boesch, Austin W, Brown, Eric P, Cheng, Hao D, Ofori, Maame Ofua, Normandin, Erica, Nigrovic, Peter A, Alter, Galit, Ackerman, Margaret E

“…Because the variable ability of the antibody constant (Fc) domain to recruit innate immune effector cells and complement is a major factor in antibody activity…”
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VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing by Shen, C-H, DeKosky, BJ, Guo, Y, Xu, K, Gu, Y, Kilam, D, Ko, SH, Kong, R, Liu, K, Louder, MK

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VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage by Shen, Chen-Hsiang, DeKosky, Brandon J., Guo, Yicheng, Xu, Kai, Gu, Ying, Kilam, Divya, Ko, Sung Hee, Kong, Rui, Liu, Kevin, Louder, Mark K., Ou, Li, Zhang, Baoshan, Chao, Cara W., Corcoran, Martin M., Feng, Eric, Huang, Jesse, Normandin, Erica, O’Dell, Sijy, Ransier, Amy, Rawi, Reda, Sastry, Mallika, Schmidt, Stephen D., Wang, Shuishu, Wang, Yiran, Chuang, Gwo-Yu, Doria-Rose, Nicole A., Lin, Bob, Zhou, Tongqing, Boritz, Eli A., Connors, Mark, Douek, Daniel C., Karlsson Hedestam, Gunilla B., Sheng, Zizhang, Shapiro, Lawrence, Mascola, John R., Kwong, Peter D.

“…Rare mutations have been proposed to restrict the development of broadly neutralizing antibodies against HIV-1, but this has not been explicitly demonstrated…”
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Powassan Virus Neuropathology and Genomic Diversity in Patients With Fatal Encephalitis by Normandin, Erica, Solomon, Isaac H, Zamirpour, Siavash, Lemieux, Jacob, Freije, Catherine A, Mukerji, Shibani S, Tomkins-Tinch, Christopher, Park, Daniel, Sabeti, Pardis C, Piantadosi, Anne

“…Abstract Background Powassan virus (POWV) is an emerging cause of severe encephalitis; very little is known about human pathogenicity due to challenges in…”
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