Search Results - "Norman, Vanessa L."
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Antibiofilm phenylethanoid glycosides from Penstemon centranthifolius
Published in Phytotherapy research (01-05-2010)“…Bioassay-guided fractionation of the antibacterial ethyl acetate-ethanol (50 : 50) extract obtained from the aerial parts of Penstemon centranthifolius led to…”
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2
Secoiridoid Glycosides from the Pitcher Plant Sarracenia alata
Published in Helvetica chimica acta (01-02-2009)“…The new secoiridoid glycoside alatenoside (6) was isolated along with the known secoiridoid glycosides morroniside (1), (7α)‐7‐O‐methylmorroniside (2),…”
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3
Optimized plant compound with potent anti-biofilm activity across gram-negative species
Published in Bioorganic & medicinal chemistry (01-03-2020)“…Many human diseases, including cystic fibrosis lung infections, are caused or exacerbated by bacterial biofilms. Specialized modes of motility, including…”
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Bifidenone: Structure–Activity Relationship and Advanced Preclinical Candidate
Published in Journal of medicinal chemistry (09-08-2018)“…Bifidenone is a novel natural tubulin polymerization inhibitor that exhibits antiproliferative activity against a range of human cancer cell lines, making it…”
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Isolation and Identification of the Novel Tubulin Polymerization Inhibitor Bifidenone
Published in Journal of natural products (Washington, D.C.) (24-03-2017)“…The pursuit of structurally novel compounds has led to the isolation of a series of neolignans (2–6), for which the structures have been determined from…”
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Antibacterial chromene and chromane stilbenoids from Hymenocardia acida
Published in Phytochemistry (Oxford) (01-02-2014)“…Six chromene stilbenoids and one chromane stilbenoid were isolated from the African tree Hymenocardia acida. Several were moderately active against…”
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Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum
Published in Journal of natural products (Washington, D.C.) (28-08-2015)“…The compass plant, Silphium laciniatum, is an iconic perennial plant of the North American tallgrass prairie. The plants of the tallgrass prairie historically…”
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Antibacterial clerodane diterpenes from Goldenrod ( Solidago virgaurea)
Published in Phytochemistry (Oxford) (2010)“…Nine clerodane diterpenes, solidagoic acids C-I ( 1– 7), cleroda-3,13(14)-dien-16,15:18,19-diolide ( 8) and cleroda-3,13(14)-dien-15,16:18,19-diolide ( 9) were…”
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Diterpenes from the Endangered Goldenrod Solidago shortii
Published in Journal of natural products (Washington, D.C.) (27-06-2014)“…Species extinction is tantamount to loss of chemical diversity, and so it is important to seize all opportunities to study species on the brink of extinction…”
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Phenylpropanoids from Phragmipedium calurum and their antiproliferative activity
Published in Phytochemistry (Oxford) (01-10-2012)“…Seven stilbenes and one alkylresorcinol were isolated from the orchid Phragmipedium calurum during a screen for anticancer compounds. They were evaluated for…”
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Cytotoxic and Antibacterial Beilschmiedic Acids from a Gabonese Species of Beilschmiedia
Published in Journal of natural products (Washington, D.C.) (27-07-2012)“…High-throughput natural products chemistry methods have facilitated the isolation of eight new (1–8) and two known (9 and 10) beilschmiedic acid derivatives…”
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Acetylated Dammarane-Type Bisdesmosides from Combretum inflatum
Published in Journal of natural products (Washington, D.C.) (27-09-2013)“…The first study of the chemical constituents of Combretum inflatum has resulted in the isolation of seven new acetylated dammarane-type bisdesmosides (1–7)…”
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Antibiotic Indole Sesquiterpene Alkaloid from Greenwayodendron suaveolens with a New Natural Product Framework
Published in Journal of natural products (Washington, D.C.) (28-05-2010)“…High-throughput natural products chemistry methods have led to the isolation of three new (1−3) and two known indole sesquiterpene alkaloids (4, 5) from…”
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Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis
Published in Phytochemistry (Oxford) (01-02-2012)“…A phytochemical investigation of Monanthotaxis congoensis afforded nine polyoxygenated cyclohexenes, one of which displayed moderate antiproliferative activity…”
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Isolation of apoptosis-inducing stilbenoids from four members of the Orchidaceae family
Published in Planta medica (01-01-2012)“…High-throughput natural product research produced a suite of anticancer hits among several species of the Orchidaceae family (Oncidium microchilum, O. isthmi,…”
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Antibacterial activity of Taxodium ascendens diterpenes against methicillin-resistant Staphylococcus aureus
Published in Natural product communications (01-08-2014)“…One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens. Of these, demethylcryptojaponol (2),…”
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Abronione, a rotenoid from the desert annual Abronia villosa
Published in Phytochemistry letters (15-06-2011)“…A high-throughput phytochemical investigation of Abronia villosa afforded a new rotenoid designated abronione ( 1). The structure of 1 was determined using…”
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Abstract 2073: Profiling and comparison of breast cancer standard of care agents using the OncoPanel™ cell-based profiling service
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Abstract Oncology drugs with clinical utility for the treatment of breast cancer span a wide range of different mechanisms and cancer type profiles…”
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Abstract 1391: Establishment and validation of a high-content imaging assay with a 14-day incubation for the testing of epigenetic target-based therapeutics
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Abstract Given the importance and significance of targeting mutations and epigenetic modification in cancer therapy, we sought to expand on our ability to test…”
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Abstract 2260: Exploring drug response metrics for biomarker discovery using the OncoPanel™ cell-based profiling service
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Abstract Using drug response data, generated by the OncoPanelTM cell-based profiling service, we investigated the differences between traditional and…”
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