Search Results - "Norman, Mantana K"

Long-term behavioral consequences of prenatal MDMA exposure by Thompson, Valerie B, Heiman, Justin, Chambers, James B, Benoit, Stephen C, Buesing, William R, Norman, Mantana K, Norman, Andrew B, Lipton, Jack W

“…Abstract The current study sought to determine whether prenatal 3,4-methylenedioxy- N -methamphetamine (MDMA) exposure from E14–20 in the rat resulted in…”
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The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats by Norman, Andrew B, Norman, Mantana K, Buesing, William R, Tabet, Michael R, Tsibulsky, Vladimir L, Ball, William J

“…The predominantly human sequence anti-cocaine monoclonal antibody (mAb), 2E2, has high affinity and specificity for cocaine and antagonizes cocaine…”
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A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice by Norman, Andrew B, Tabet, Michael R, Norman, Mantana K, Buesing, William R, Pesce, Amadeo J, Ball, William J

“…The predominantly human sequence, high-affinity anticocaine monoclonal antibody (mAb) 2E2 was cleared slowly from mouse blood by a first-order process with an…”
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Maintained cocaine self-administration is determined by quantal responses: implications for the measurement of antagonist potency by Norman, Andrew B, Tabet, Michael R, Norman, Mantana K, Tsibulsky, Vladimir L

“…The change in frequency of cocaine self-administration as a function of the unit dose is widely assumed to represent a graded pharmacodynamic response…”
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Using the self-administration of apomorphine and cocaine to measure the pharmacodynamic potencies and pharmacokinetics of competitive dopamine receptor antagonists by Norman, Andrew B., Tabet, Michael R., Norman, Mantana K., Tsibulsky, Vladimir L.

“…▶ Antagonists increased the equiactive concentration of self-administered agonists. ▶ The agonist concentration ratio was directly proportional to the…”
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The affinity of D2-like dopamine receptor antagonists determines the time to maximal effect on cocaine self-administration by Norman, Andrew B, Tabet, Michael R, Norman, Mantana K, Fey, Brittney K, Tsibulsky, Vladimir L, Millard, Ronald W

“…Differences in the time to maximal effect (T(max)) of a series of dopamine receptor antagonists on the self-administration of cocaine are not consistent with…”
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Competitive dopamine receptor antagonists increase the equiactive cocaine concentration during self-administration by Norman, Andrew B., Norman, Mantana K., Tabet, Michael R., Tsibulsky, Vladimir L., Pesce, Amadeo J.

“…Competitive dopamine receptor antagonists increase the rate of cocaine self‐administration. As the rate of self‐administration at a particular unit dose is…”
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The self-administration of WIN 35,428 and cocaine: comparisons of satiety threshold and elimination half-life in rats by Norman, Andrew B, Buesing, William R, Norman, Mantana K, Tabet, Michael R, Tsibulsky, Vladimir L

“…Rats that self-administered cocaine at unit doses between 0.75 and 12 μmol/kg with mean inter-injection intervals between approximately 2 and 18 min also…”
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Transient amelioration of the sensitization of cocaine-induced behaviors in rats by the induction of tolerance by Dalia, Asad D, Norman, Mantana K, Tabet, Michael R, Schlueter, Kevin T, Tsibulsky, Vladimir L, Norman, Andrew B

“…Intermittent administration of cocaine produced a progressive increase in the stereotypy response of rats to a challenge dose of cocaine (7.5 mg/kg, i.p.)…”
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Using cocaine self‐administration to determine whether dopamine receptor antagonists are potential substrates for p‐glycoprotein‐ like efflux transporters in the rat blood‐brain barrier by Norman, Andrew B., Tabet, Michael R., Norman, Mantana K., Tsibulsky, Vladimir L.

“…Abstract only Among a series of dopamine receptor antagonists the in vivo potency of spiperone is less than (−)eticlopride despite having higher in vitro…”
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Multiple cocaine unit doses are redundant when measuring the magnitude of effect of dopamine receptor antagonists on self‐administration by Norman, Andrew B., Tabet, Michael R., Norman, Mantana K., Tsibulsky, Vladimir L.

“…The change in frequency of cocaine self‐administration as a function of unit dose is widely assumed to represent a graded pharmacodynamic response. An…”
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Affinity of dopamine receptor antagonists determines the time to maximum effect on cocaine self‐administration by Fey, Brittney K, Tabet, Michael R, Norman, Mantana K, Tsibulsky, Vladimir L, Millard, Ronald W, Norman, Andrew B

“…The time course of the dopamine receptor antagonist‐induced acceleration of cocaine self‐administration may correspond to the time to achieve maximum…”
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The drug self‐administration assay measures the pharmacodynamic and pharmacokinetic potencies of receptor antagonists by Norman, Andrew B., Norman, Mantana K., Buesing, William R., Tabet, Michael R., Tsibulsky, Vladimir L.

“…Abstract only According to pharmacological theory, competitive antagonists increase the concentration of agonist required to produce a defined magnitude of…”
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A human anti‐cocaine monoclonal antibody antagonizes the cocaine‐induced reinstatement of self‐administration in rats by Norman, Andrew B., Norman, Mantana K., Buesing, William R., Tabet, Michael R., Tsibulsky, Vladimir L., Ball, William J.

“…Abstract only Immunotherapy may represent a viable alternative to pharmacotherapy for cocaine abuse. The predominantly human sequence anti‐cocaine monoclonal…”
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Priming threshold: a novel quantitative measure of the reinstatement of cocaine self-administration by Norman, Andrew B., Norman, Mantana K., Hall, James F., Tsibulsky, Vladimir L.

“…The intravenous injection of cocaine has been reported to reliably reinstate (prime) the self-administration of cocaine in animals. We report herein that there…”
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