Search Results - "Norman, Jill T"

Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics by Fine, Leon G., Norman, Jill T.

“…In chronic kidney disease, functional impairment correlates with tubulointerstitial fibrosis characterised by inflammation, accumulation of extracellular…”
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Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells by Haschler, Timo N., Horsley, Harry, Balys, Monika, Anderson, Glenn, Taanman, Jan-Willem, Unwin, Robert J., Norman, Jill T.

“…Ischemia is a major cause of kidney damage. Proximal tubular epithelial cells (PTECs) are highly susceptible to ischemic insults that frequently cause acute…”
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INTRARENAL OXYGENATION IN CHRONIC RENAL FAILURE by Norman, Jill T, Fine, Leon G

“…SUMMARY 1 In chronic renal failure (CRF), renal impairment correlates with tubulointerstitial fibrosis characterized by inflammation, interstitial expansion…”
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Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury by Menzies, Robert I., Booth, John W.R., Mullins, John J., Bailey, Matthew A., Tam, Frederick W.K., Norman, Jill T., Unwin, Robert J.

“…Diabetes is a leading cause of renal disease. Glomerular mesangial expansion and fibrosis are hallmarks of diabetic nephropathy and this is thought to be…”
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Urinary exosome proteomic profiling defines stage-specific rapid progression of autosomal dominant polycystic kidney disease and tolvaptan efficacy by Raby, Katie L., Horsely, Harry, McCarthy-Boxer, Aidan, Norman, Jill T., Wilson, Patricia D.

“…•Proteomic profiling of urinary exosomes distinguishes between rapidly and slowly progressing ADPKD.•Proteomic profiling of urinary exosomes distinguishes…”
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Retinoic acid receptor-dependent, cell-autonomous, endogenous retinoic acid signaling and its target genes in mouse collecting duct cells by Wong, Yuen Fei, Wilson, Patricia D, Unwin, Robert J, Norman, Jill T, Arno, Matthew, Hendry, Bruce M, Xu, Qihe

“…Vitamin A is necessary for kidney development and has also been linked to regulation of solute and water homeostasis and to protection against kidney stone…”
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Identification of an Altered Matrix Signature in Kidney Aging and Disease by Randles, Michael J, Lausecker, Franziska, Kong, Qingyang, Suleiman, Hani, Reid, Graeme, Kolatsi-Joannou, Maria, Davenport, Bernard, Tian, Pinyuan, Falcone, Sara, Potter, Paul, Van Agtmael, Tom, Norman, Jill T, Long, David A, Humphries, Martin J, Miner, Jeffrey H, Lennon, Rachel

“…Accumulation of extracellular matrix in organs and tissues is a feature of both aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial…”
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Retinoids in nephrology: Promises and pitfalls by Xu, Qihe, Lucio-Cazana, Javier, Kitamura, Masanori, Ruan, Xiongzhong, Fine, Leon G., Norman, Jill T.

“…Retinoids in nephrology: Promises and pitfalls. Retinoids, a family of vitamin A metabolites or analogs, play an important role in regulating cell…”
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Restoring the renal microvasculature to treat chronic kidney disease by Long, David A., Norman, Jill T., Fine, Leon G.

“…Revascularization alone might be sufficient to restore kidney function and regenerate the structure of the diseased kidney. In this Perspectives article, David…”
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Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension by Tam, Angela Y.Y., Horwell, Amy L., Trinder, Sarah L., Khan, Korsa, Xu, Shiwen, Ong, Voon, Denton, Christopher P., Norman, Jill T., Holmes, Alan M., Bou-Gharios, George, Abraham, David J.

“…•CCN2 is selectively and exquisitely induced by the TGF-β signalling pathway.•CCN2 appears to mediate many of the activities characteristic of…”
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Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring by Ahadome, Sarah D., Abraham, David J., Rayapureddi, Suryanarayana, Saw, Valerie P., Saban, Daniel R., Calder, Virginia L., Norman, Jill T., Ponticos, Markella, Daniels, Julie T., Dart, John K.

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Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus by Shakib, Kaveh, Norman, Jill T., Fine, Leon G., Brown, Larry R., Godovac-Zimmermann, Jasminka

“…Proteomics methods were used to characterize proteins that change their form or abundance in the nucleus of NRK49F rat kidney fibroblasts during prolonged…”
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In vitro models of TGF-beta-induced fibrosis suitable for high-throughput screening of antifibrotic agents by Xu, Qihe, Norman, Jill T, Shrivastav, Shashi, Lucio-Cazana, Javier, Kopp, Jeffrey B

“…Progressive fibrosis is a cause of progressive organ dysfunction. Lack of quantitative in vitro models of fibrosis accounts, at least partially, for the slow…”
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The binding of the bone morphogenetic protein antagonist gremlin to kidney heparan sulfate: Such binding is not essential for BMP antagonism by Tatsinkam, Arnold Junior, Rune, Naomi, Smith, Joy, Norman, Jill T., Mulloy, Barbara, Rider, Christopher C.

“…Gremlin-1, a bone morphogenetic protein (BMP) antagonist, has essential roles in kidney and limb bone development, and is important in chronic diseases…”
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Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage by Tomlinson, James A P, Caplin, Ben, Boruc, Olga, Bruce-Cobbold, Claire, Cutillas, Pedro, Dormann, Dirk, Faull, Peter, Grossman, Rebecca C, Khadayate, Sanjay, Mas, Valeria R, Nitsch, Dorothea D, Wang, Zhen, Norman, Jill T, Wilcox, Christopher S, Wheeler, David C, Leiper, James

“…Nitric oxide (NO) production is diminished in many patients with cardiovascular and renal disease. Asymmetric dimethylarginine (ADMA) is an endogenous…”
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Assessment of Measurement of Salivary Urea by ATR-FTIR Spectroscopy to Screen for CKD by Lin, Tzu-Ling, Evans, Rhys D R, Unwin, Robert J, Norman, Jill T, Rich, Peter R

“…Stages of CKD are currently defined by eGFR and require measurement of serum creatinine concentrations. Previous studies have shown a good correlation between…”
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Hypoxia promotes fibrogenesis in human renal fibroblasts by Norman, Jill T., Clark, Ian M., Garcia, Patricia L.

“…Hypoxia promotes fibrogenesis in human renal fibroblasts. The mechanisms underlying progressive renal fibrosis are unknown, but the common association of…”
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Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia by Fine, Leon G., Bandyopadhay, Debasish, Norman, Jill T.

“…Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia. The…”
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Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring by Ahadome, Sarah D, Abraham, David J, Rayapureddi, Suryanarayana, Saw, Valerie P, Saban, Daniel R, Calder, Virginia L, Norman, Jill T, Ponticos, Markella, Daniels, Julie T, Dart, John K

“…Mucous membrane pemphigoid (MMP) is a systemic mucosal scarring disease, commonly causing blindness, for which there is no antifibrotic therapy. Aldehyde…”
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Protecting the microvasculature: a Tie-ght connection to ameliorating chronic kidney disease? by Norman, Jill T

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