Search Results - "Norling, Lucy V."

Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation by Arnardottir, Hildur H, Dalli, Jesmond, Norling, Lucy V, Colas, Romain A, Perretti, Mauro, Serhan, Charles N

“…Uncontrolled inflammation is a unifying component of many chronic inflammatory diseases, such as arthritis. Resolvins (Rvs) are a new family from the…”
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Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis by Chen, Jianmin, Norling, Lucy V., Mesa, Jose Garrido, De Paula Silva, Marina, Burton, Sophie E., Reutelingsperger, Chris, Perretti, Mauro, Cooper, Dianne

“…Rheumatoid arthritis (RA) carries a twofold increased incidence of heart failure with preserved ejection fraction, accompanied by diastolic dysfunction, which…”
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Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis by Headland, Sarah E, Jones, Hefin R, Norling, Lucy V, Kim, Andrew, Souza, Patricia R, Corsiero, Elisa, Gil, Cristiane D, Nerviani, Alessandra, Dell'Accio, Francesco, Pitzalis, Costantino, Oliani, Sonia M, Jan, Lily Y, Perretti, Mauro

“…Microvesicles (MVs) are emerging as a new mechanism of intercellular communication by transferring cellular lipid and protein components to target cells, yet…”
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Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing by Norling, Lucy V, Spite, Matthew, Yang, Rong, Flower, Roderick J, Perretti, Mauro, Serhan, Charles N

“…Endogenous microparticles (MPs) were systematically profiled during the time course of self-limited inflammation. Precursors for specialized proresolving lipid…”
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Cutting-Edge Analysis of Extracellular Microparticles using ImageStreamX Imaging Flow Cytometry by Headland, Sarah E., Jones, Hefin R., D'Sa, Adelina S. V., Perretti, Mauro, Norling, Lucy V.

“…Interest in extracellular vesicle biology has exploded in the past decade, since these microstructures seem endowed with multiple roles, from blood coagulation…”
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Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation by Chen, Jianmin, Norling, Lucy V, Cooper, Dianne

“…Rheumatoid arthritis is a chronic, systemic inflammatory disease that carries an increased risk of mortality due to cardiovascular disease. The link between…”
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Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages by Rhys, Hefin I., Dell'Accio, Francesco, Pitzalis, Costantino, Moore, Adrian, Norling, Lucy V., Perretti, Mauro

“…Microvesicles (MVs) are emerging as a novel means to enact cell-to-cell communication in inflammation. Here, we aimed to ascertain the ability of…”
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β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis by Hussain, Mohammed Tayab, Austin-Williams, Shani, Wright, Thomas Dudley, Dhawan, Umesh Kumar, Pinto, Andreia L, Cooper, Dianne, Norling, Lucy V

“…Osteoarthritis (OA) is the most prevalent age-related degenerative disorder, which severely reduces the quality of life of those affected. Whilst management…”
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Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis by Norling, Lucy V, Headland, Sarah E, Dalli, Jesmond, Arnardottir, Hildur H, Haworth, Oliver, Jones, Hefin R, Irimia, Daniel, Serhan, Charles N, Perretti, Mauro

“…Rheumatoid arthritis (RA) is a debilitating disease characterized by persistent accumulation of leukocytes within the articular cavity and synovial tissue…”
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Microparticle alpha‐2‐macroglobulin enhances pro‐resolving responses and promotes survival in sepsis by Dalli, Jesmond, Norling, Lucy V, Montero‐Melendez, Trinidad, Canova, Donata Federici, Lashin, Hazem, Pavlov, Anton M, Sukhorukov, Gleb B, Hinds, Charles J, Perretti, Mauro

“…Incorporation of locally produced signaling molecules into cell‐derived vesicles may serve as an endogenous mediator delivery system. We recently reported that…”
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Galectin‐3–null mice display defective neutrophil clearance during acute inflammation by Wright, Rachael D, Souza, Patricia R., Flak, Magdalena B., Thedchanamoorthy, Prasheetha, Norling, Lucy V., Cooper, Dianne

“…Expression of galectin‐3 by exudated neutrophils drives neutrophil apoptosis and clearance in a model of self‐resolving peritonitis. Galectin‐3 has been…”
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Endogenous galectins and the control of the host inflammatory response by Norling, Lucy V, Perretti, Mauro, Cooper, Dianne

“…A new era of research is being devoted to deciphering endogenous mediators and mechanisms that are in place to resolve the inflammatory response. Accruing…”
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Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction by Chen, Jianmin, Austin-Williams, Shani, O'Riordan, Caroline Elizabeth, Claria-Ribas, Pol, Sugimoto, Michelle A, Norling, Lucy V, Thiemermann, Christoph, Perretti, Mauro

“…Abstract Using a global formyl peptide receptor (Fpr) 2 knockout mouse colony, we have reported the modulatory properties of this pro-resolving receptor in…”
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Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow by Cooper, Dianne, Norling, Lucy V., Perretti, Mauro

“…Galectin‐1 (Gal‐1) is a β‐galactoside‐binding protein endowed with anti‐inflammatory properties. The purpose of this study was to investigate the effects of…”
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A Pro-resolving Role for Galectin-1 in Acute Inflammation by Law, Hannah L, Wright, Rachael D, Iqbal, Asif J, Norling, Lucy V, Cooper, Dianne

“…Galectin-1 (Gal-1) exerts immune-regulatory and anti-inflammatory actions in animal models of acute and chronic inflammation. Its release into the…”
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Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody by Topping, Louise M, Thomas, Bethan L, Rhys, Hefin I, Tremoleda, Jordi L, Foster, Martyn, Seed, Michael, Voisin, Mathieu-Benoit, Vinci, Chiara, Law, Hannah L, Perretti, Mauro, Norling, Lucy V, Azevedo, Helena S, Nissim, Ahuva

“…The targeted delivery of therapies to diseased tissues offers a safe opportunity to achieve optimal efficacy while limiting systemic exposure. These…”
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The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections by Souza, Patricia R, Walker, Mary E, Goulding, Nicolas J, Dalli, Jesmond, Perretti, Mauro, Norling, Lucy V

“…G-protein-coupled receptor 40 (GPR40) is known to play a role in the regulation of fatty acids, insulin secretion, and inflammation. However, the function of…”
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Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity by Oggero, Silvia, Gaetano, Monica, Marcone, Simone, Fitzsimons, Stephen, Pinto, Andreia L., Ikramova, Dinara, Barry, Mary, Burke, David, Montero‐Melendez, Trinidad, Cooper, Dianne, Burgoyne, Thomas, Belton, Orina, Norling, Lucy V., Brennan, Eoin P., Godson, Catherine, Perretti, Mauro

“…Extracellular vesicles (EVs) are emerging as key players in different stages of atherosclerosis. Here we provide evidence that EVs released by mixed aggregates…”
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The resolution of inflammation: Principles and challenges by Headland, Sarah E, Norling, Lucy V

“…Highlights • Resolution of inflammation is governed by key lipid, protein, peptide and gaseous mediators. • Resolving inflammation requires orchestrated…”
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Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis by Norling, Lucy V, Headland, Sarah E, Dalli, Jesmond, Arnardottir, Hildur H, Haworth, Oliver, Jones, Hefin R, Irimia, Daniel, Serhan, Charles N, Perretti, Mauro

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