A case of zonisamide-induced toxic epidermal necrolysis with acute respiratory failure

Dear Editor, Toxic epidermal necrolysis (TEN) is a life-threatening cutaneous adverse drug reaction characterized by a high fever and widespread erosions of the skin and mucosa, including the lips, oropharynx and genital region. The visceral organs are frequently affected in TEN, and treatment in th...

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Bibliographic Details
Published in:	Allergology International Vol. 69; no. 4; pp. 642 - 644
Main Authors:	Miki Kumea, Yukinobu Nakagawaa, Eiji Kiyoharaa, Noriko Arasea, Mari Wataya-Kanedaa, Moto Yagab, Masahiro Yanagawac, Manabu Fujimotoa
Format:	Journal Article
Language:	Japanese
Published:	JAPANESE SOCIETY OF ALLERGOLOGY 01-10-2020
Online Access:	Get full text
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Summary:	Dear Editor, Toxic epidermal necrolysis (TEN) is a life-threatening cutaneous adverse drug reaction characterized by a high fever and widespread erosions of the skin and mucosa, including the lips, oropharynx and genital region. The visceral organs are frequently affected in TEN, and treatment in the intensive-care unit (ICU) is required, especially in patients with respiratory failure. Many therapeutic options, including systemic steroids, plasmapheresis and intravenous immunoglobulin (IVIG), have been used and are considered effective for the treatment of TEN, although no gold standard has been established. In Japan, systemic high-dose corticosteroid therapy has been chosen as the first-line treatment according to the Japanese guideline for the management of Stevens-Johnson syndrome (SJS) and TEN, and the addition of steroid pulse therapy, plasmapheresis and/or IVIG is recommended in intractable cases.
ISSN:	1323-8930