Search Results - "Norga, Koen"

Development of an integrated competency framework for postgraduate paediatric training: a Delphi study by Robbrecht, Marieke, Norga, Koen, Van Winckel, Myriam, Valcke, Martin, Embo, Mieke

“…Competency-based education (CBE) has transformed medical training during the last decades. In Flanders (Belgium), multiple competency frameworks are being used…”
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NTRK Fusions in a Sarcomas Series: Pathology, Molecular and Clinical Aspects by Siozopoulou, Vasiliki, Marcq, Elly, De Winne, Koen, Norga, Koen, Schmitz, Gertjan, Duwel, Valerie, Delvenne, Philippe, Smits, Evelien, Pauwels, Patrick

“…Targeting molecular alterations has been proven to be an inflecting point in tumor treatment. Especially in recent years, inhibitors that target the tyrosine…”
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Adjuvant Wilms’ tumour 1-specific dendritic cell immunotherapy complementing conventional therapy for paediatric patients with high-grade glioma and diffuse intrinsic pontine glioma: protocol of a monocentric phase I/II clinical trial in Belgium by Van Genechten, Toon, De Laere, Maxime, Van den Bossche, Jolien, Stein, Barbara, De Rycke, kim, Deschepper, Caroline, Hazes, Katja, Peeters, Renke, Couttenye, Marie-Madeleine, Van De Walle, Katrien, Roelant, Ella, Maes, Sabine, Vanden Bossche, Stephanie, Dekeyzer, Sven, Huizing, Manon, Caluwaert, Kim, Nijs, Griet, Cools, Nathalie, Verlooy, Joris, Norga, Koen, Verhulst, Stijn, Anguille, Sebastien, Berneman, Zwi, Lion, Eva

“…IntroductionDiffuse intrinsic pontine glioma (DIPG) and paediatric high-grade glioma (pHGG) are aggressive glial tumours, for which conventional treatment…”
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Dilemmas in the Management of an Infant with Neuroblastoma Metastasized to the Muscles by van Heerden, Jaques, van den Akker, Machiel, Verlooy, Joris, Van Roy, Nadine, Laureys, Geneviève, Norga, Koen

“…Abstract The risk stratification of infants with metastatic neuroblastoma (NB) has evolved over time from stage 4/M or IVs/4S/MS/Ms according to various…”
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Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy by Storkebaum, Erik, Leitão-Gonçalves, Ricardo, Godenschwege, Tanja, Nangle, Leslie, Mejia, Monica, Bosmans, Inge, Ooms, Tinne, Jacobs, An, Van Dijck, Patrick, Yang, Xiang-Lei, Schimmel, Paul, Norga, Koen, Timmerman, Vincent, Callaerts, Patrick, Jordanova, Albena

“…Dominant-intermediate Charcot-Marie-Tooth neuropathy (DI-CMT) is characterized by axonal degeneration and demyelination of peripheral motor and sensory…”
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Together Against Leukemia—the Strength of a Small Community by Jonckers, Bart, Michielsen, Toke, Severijns, Nina, Elst, Heidi, Simoens, Fried’l, Norga, Koen, van den Akker, Machiel, van Heerden, Jaques, Verlooy, Joris

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Embryonic expression patterns of Drosophila ACS family genes related to the human sialin gene by Laridon, Bram, Callaerts, Patrick, Norga, Koen

“…The anion/cation symporter (ACS) family is a large subfamily of the major facilitator superfamily (MFS) of transporters. ACS family permeases are widely…”
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Accelerating the Global Development of Pediatric Cancer Drugs: A Call to Coordinate the Submissions of Pediatric Investigation Plans and Pediatric Study Plans to the European Medicines Agency and US Food and Drug Administration by Reaman, Gregory, Karres, Dominik, Ligas, Franca, Lesa, Giovanni, Casey, Denise, Ehrlich, Lori, Norga, Koen, Pazdur, Richard

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The AMPK/SNF1/SnRK1 fuel gauge and energy regulator: structure, function and regulation by Ghillebert, Ruben, Swinnen, Erwin, Wen, Jing, Vandesteene, Lies, Ramon, Matthew, Norga, Koen, Rolland, Filip, Winderickx, Joris

“…All life forms on earth require a continuous input and monitoring of carbon and energy supplies. The AMP‐activated kinase (AMPK)/sucrose nonfermenting1…”
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European regulatory strategy for supporting childhood cancer therapy developments by Karres, Dominik, Lesa, Giovanni, Ligas, Franca, Benchetrit, Sylvie, Galluzzo, Sara, Van Malderen, Karen, Sterba, Jaroslav, van Dartel, Maaike, Renard, Marleen, Sisovsky, Peter, Wang, Siri, Norga, Koen

“…Regulatory decisions on paediatric investigation plans (PIPs) aim at making effective and safe medicines timely available for children with high unmet medical…”
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Exploring residents and supervisors' workplace learning needs during postgraduate medical education by Robbrecht, Marieke, Van Winckel, Myriam, Norga, Koen, Embo, Mieke

“…To identify the main enablers and challenges for workplace learning during postgraduate medical education among residents and their supervisors involved in…”
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Exploring residents and supervisors' workplace learning needs during postgraduate medical education by Robbrecht, Marieke, Van Winckel, Myriam, Norga, Koen, Embo, Mieke

“…Objectives: To identify the main enablers and challenges for workplace learning during postgraduate medical education among residents and their supervisors…”
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ACCELERATE Paediatric Strategy Forums: an advance for oncological drug development? by Pearson, Andrew D J, de Rojas, Teresa, Karres, Dominik, Reaman, Gregory, Scobie, Nicole, Fox, Elizabeth, Lesa, Giovanni, Ligas, Franca, Norga, Koen, Nysom, Karsten, Pappo, Alberto, Weigel, Brenda, Weiner, Susan, Vassal, Gilles

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Impact of ACCELERATE Paediatric Strategy Forums: a review of the value of multi-stakeholder meetings in oncology drug development: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration by Pearson, Andrew D J, de Rojas, Teresa, Karres, Dominik, Reaman, Gregory, Scobie, Nicole, Fox, Elizabeth, Lesa, Giovanni, Ligas, Franca, Norga, Koen, Nysom, Karsten, Pappo, Alberto, Weigel, Brenda, Weiner, Susan L, Vassal, Gilles

“…In a landscape of an increasing number of products and histology and age agnostic trials for rare patient cancer, prioritization of products is required…”
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ACCELERATE – Five years accelerating cancer drug development for children and adolescents by Pearson, Andrew D.J., Weiner, Susan L., Adamson, Peter C., Karres, Dominik, Reaman, Gregory, Rousseau, Raphaël, Blanc, Patricia, Norga, Koen, Skolnik, Jeffrey, Kearns, Pam, Scobie, Nicole, Barry, Elly, Marshall, Lynley V., Knox, Leona, Caron, Hubert, Wariabharaj, Darshan, Pappo, Alberto, DuBois, Steven G., Gore, Lia, Kieran, Mark, Weigel, Brenda, Fox, Elizabeth, Nysom, Karsten, de Rojas, Teresa, Vassal, Gilles

“…Rapid evaluation and subsequent regulatory approval of new drugs are critical to improving survival and reducing long-term side-effects for children and…”
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Second Paediatric Strategy Forum for anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies: ACCELERATE in collaboration with the European Medicines Agency with the participation of the Food and Drug Administration by Pearson, Andrew D J, Barry, Elly, Mossé, Yael P, Ligas, Franca, Bird, Nick, de Rojas, Teresa, Zimmerman, Zachary F, Wilner, Keith, Woessmann, Willi, Weiner, Susan, Weigel, Brenda, Venkatramani, Rajkumar, Valteau, Dominique, Trahair, Toby, Smith, Malcolm, Singh, Sonia, Selvaggi, Giovanni, Scobie, Nicole, Schleiermacher, Gudrun, Richardson, Nicholas, Park, Julie, Nysom, Karsten, Norga, Koen, Merino, Margret, McDonough, Joe, Matloub, Yousif, Marshall, Lynley V, Lowe, Eric, Lesa, Giovanni, Irwin, Meredith, Karres, Dominik, Gajjar, Amar, Doz, François, Fox, Elizabeth, DuBois, Steven G, Donoghue, Martha, Casanova, Michela, Caron, Hubert, Buenger, Vickie, Bradford, Diana, Blanc, Patricia, Barone, Amy, Reaman, Gregory, Vassal, Gilles

“…The first (2017) and sixth (2021) multistakeholder Paediatric Strategy Forums focused on anaplastic lymphoma kinase (ALK) inhibition in paediatric…”
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Impact of ACCELERATE Paediatric Strategy Forums: a review of the value of multi-stakeholder meetings in oncology drug development by Pearson, Andrew D J, de Rojas, Teresa, Karres, Dominik, Reaman, Gregory, Scobie, Nicole, Fox, Elizabeth, Lesa, Giovanni, Ligas, Franca, Norga, Koen, Nysom, Karsten, Pappo, Alberto, Weigel, Brenda, Weiner, Susan L, Vassal, Gilles

“…In a landscape of an increasing number of products and histology and age agnostic trials for rare patient cancer, prioritization of products is required…”
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Can a Multistakeholder Prioritization Structure Support Regulatory Decision Making? A Review of Pediatric Oncology Strategy Forums Reflecting on Challenges and Opportunities of this Concept by Karres, Dominik, Lesa, Giovanni, Ligas, Franca, Annunen, Pia, Dartel, Maaike, Demolis, Pierre, Galluzzo, Sara, Herold, Ralf, Criekingen, Olga Kholmanskikh, Stoyanova‐Beninska, Violeta, Norga, Koen

“…Timely and successful drug development for rare cancer populations, such as pediatric oncology, requires consolidated efforts in the spirit of shared…”
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Implementation of mechanism of action biology-driven early drug development for children with cancer by Pearson, Andrew D.J, Herold, Ralf, Rousseau, Raphaël, Copland, Chris, Bradley-Garelik, Brigid, Binner, Debbie, Capdeville, Renaud, Caron, Hubert, Carleer, Jacqueline, Chesler, Louis, Geoerger, Birgit, Kearns, Pamela, Marshall, Lynley V, Pfister, Stefan M, Schleiermacher, Gudrun, Skolnik, Jeffrey, Spadoni, Cesare, Sterba, Jaroslav, van den Berg, Hendrick, Uttenreuther-Fischer, Martina, Witt, Olaf, Norga, Koen, Vassal, Gilles

“…Abstract An urgent need remains for new paediatric oncology drugs to cure children who die from cancer and to reduce drug-related sequelae in survivors. In…”
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Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration by Pearson, Andrew Dj, Allen, Carl, Fangusaro, Jason, Hutter, Caroline, Witt, Olaf, Weiner, Susan, Reaman, Gregory, Russo, Mark, Bandopadhayay, Pratiti, Ahsan, Sama, Barone, Amy, Barry, Elly, de Rojas, Teresa, Fisher, Michael, Fox, Elizabeth, Bender, Julia Glade, Gore, Lia, Hargrave, Darren, Hawkins, Doug, Kreider, Brent, Langseth, Abraham J, Lesa, Giovanni, Ligas, Franca, Marotti, Marcelo, Marshall, Lynley V, Nasri, Kahina, Norga, Koen, Nysom, Karsten, Pappo, Alberto, Rossato, Gianluca, Scobie, Nicole, Smith, Malcolm, Stieglitz, Elliot, Weigel, Brenda, Weinstein, Amy, Viana, Ruth, Karres, Dominik, Vassal, Gilles

“…As the mitogen-activated protein kinase (MAPK) signalling pathway is activated in many paediatric cancers, it is an important therapeutic target. Currently, a…”
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