Search Results - "Nores, Gustavo A."

Evidence for spontaneous regulation of the humoral IgM anti‐GM1 autoimmune response by IgG antibodies in multifocal motor neuropathy patients by Di Egidio, Marianna, Bacaglio, Cristian R., Arrejoría, Rocio, Villa, Andrés M., Nores, Gustavo A., Lopez, Pablo H. H.

“…Abstract Background and Aims Multifocal motor neuropathy (MMN) is a peripheral nerve disorder characterized by slow progressive distal asymmetric weakness with…”
Get full text

Extrinsic Functions of Lectin Domains in O-N-Acetylgalactosamine Glycan Biosynthesis by Lorenz, Virginia, Ditamo, Yanina, Cejas, Romina B., Carrizo, Maria E., Bennett, Eric P., Clausen, Henrik, Nores, Gustavo A., Irazoqui, Fernando J.

“…Glycan biosynthesis occurs mainly in Golgi. Molecular organization and functional regulation of this process are not well understood. We evaluated the…”
Get full text

The Antineoplastic Lectin of the Common Edible Mushroom (Agaricus bisporus) Has Two Binding Sites, Each Specific for a Different Configuration at a Single Epimeric Hydroxyl by Carrizo, Maria E., Capaldi, Stefano, Perduca, Massimiliano, Irazoqui, Fernando J., Nores, Gustavo A., Monaco, Hugo L.

“…The lectin from the common mushroom Agaricus bisporus, the most popular edible species in Western countries, has potent antiproliferative effects on human…”
Get full text

Neurological disorders-associated anti-glycosphingolipid IgG-antibodies display differentially restricted IgG subclass distribution by Lardone, Ricardo D., Irazoqui, Fernando J., Nores, Gustavo A.

“…Antibodies against several self-glycans on glycosphingolipids are frequently detected in different neurological disorders. Their pathogenic role is profusely…”
Get full text

Purified human anti-Tn and anti-T antibodies specifically recognize carcinoma tissues by Zlocowski, Natacha, Grupe, Veronica, Garay, Yohana C., Nores, Gustavo A., Lardone, Ricardo D., Irazoqui, Fernando J.

“…Described in several epithelial cancer cells, Tn- (GalNAcα1-O-Ser/Thr) and T- (Galβ3GalNAcα1-O-Ser/Thr) antigens are examples of tumor-associated antigens…”
Get full text

Individual Restriction Of Fine Specificity Variability In Anti-GM1 IgG Antibodies Associated With Guillain-Barré Syndrome by Lardone, Ricardo D., Yuki, Nobuhiro, Irazoqui, Fernando J., Nores, Gustavo A.

“…Elevated titers of serum antibodies against GM1 ganglioside are associated with a variety of autoimmune neuropathies. Much evidence indicates these…”
Get full text

Experimental Guillain-Barre syndrome induced by immunization with gangliosides: Keyhole limpet hemocyanin is required for disease triggering by Funes, Samanta C., Chiari, María Eugenia, Comín, Romina, Irazoqui, Fernando J., Nores, Gustavo A.

“…An experimental model of Guillain-Barré Syndrome has been established in recent years. Rabbits develop disease upon immunization with a single dose of an…”
Get full text

Functional control of polypeptide GalNAc-transferase 3 through an acetylation site in the C-terminal lectin domain by Lorenz, Virginia, Cejas, Romina B, Bennett, Eric P, Nores, Gustavo A, Irazoqui, Fernando J

“…O-GalNAc glycans are important structures in cellular homeostasis. Their biosynthesis is initiated by members of the polypeptide GalNAc-transferase…”
Get more information

In vivo immunomodulatory effect of the lectin from edible mushroom Agaricus bisporus by Ditamo, Yanina, Rupil, Lucia L, Sendra, Victor G, Nores, Gustavo A, Roth, German A, Irazoqui, Fernando J

“…Lectins are glycan-binding proteins that are resistant to digestion in the gastrointestinal tract and enter intact to blood circulation. The aim of this study…”
Get more information

Normally Occurring Human Anti-GM1 Immunoglobulin M Antibodies and the Immune Response to Bacteria by ALANIZ, Maria E, LARDONE, Ricardo D, YUDOWSKI, Silvia L, FARACE, Maria I, NORES, Gustavo A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

An acetylation site in lectin domain modulates the biological activity of polypeptide GalNAc-transferase-2 by Zlocowski, Natacha, Lorenz, Virginia, Bennett, Eric P, Clausen, Henrik, Nores, Gustavo A, Irazoqui, Fernando J

“…Polypeptide GalNAc-transferases (ppGalNAc-Ts) are a family of enzymes that catalyze the initiation of mucin-type O-glycosylation. All ppGalNAc-T family members…”
Get more information

Differential endocytic trafficking of neuropathy-associated antibodies to GM1 ganglioside and cholera toxin in epithelial and neural cells by Iglesias-Bartolomé, Ramiro, Trenchi, Alejandra, Comín, Romina, Moyano, Ana L., Nores, Gustavo A., Daniotti, Jose L.

“…Gangliosides are glycolipids mainly present at the plasma membrane (PM). Antibodies to gangliosides have been associated with a wide range of neuropathy…”
Get full text

Correlative Fine Specificity of Several Thomsen-Friedenreich Disaccharide-Binding Proteins with an Effect on Tumor Cell Proliferation by Irazoqui, Fernando J., Jansson, Bo, Lopez, Pablo H.H., Nores, Gustavo A.

“…Epithelial cancer cells show increased cell surface expression of mucin antigens with aberrant O-glycosylation, notably type I core (Galβ1-3GalNAcα), termed…”
Get full text

Anti-GM1 IgG antibodies in Guillain–Barré syndrome: fine specificity is associated with disease severity by Lardone, Ricardo D, Yuki, Nobuhiro, Odaka, Masaaki, Daniotti, Jose L, Irazoqui, Fernando J, Nores, Gustavo A

“…BackgroundClinical severity of Guillain–Barré syndrome (GBS) is highly variable, but the immunopathological reason is unknown.ObjectiveThe study was designed…”
Get full text

High affinity of anti-GM1 antibodies is associated with disease onset in experimental neuropathy by Comín, Romina, Yuki, Nobuhiro, Lopez, Pablo H.H., Nores, Gustavo A.

“…High antibody affinity has been proposed as a disease determinant factor in neuropathies associated with anti‐GM1 antibodies. An experimental model of…”
Get full text

Anti-GM1 antibodies as a model of the immune response to self-glycans by Nores, Gustavo A., Lardone, Ricardo D., Comín, Romina, Alaniz, María E., Moyano, Ana L., Irazoqui, Fernando J.

“…Glycans are a class of molecules with high structural variability, frequently found in the plasma membrane facing the extracellular space. Because of these…”
Get full text

Anti-idiotypic antibody mimicking a T-antigen-specific lectin inhibits human epithelial tumor cell proliferation by Sendra, Victor G, Zlocowski, Natacha, Nores, Gustavo A, Irazoqui, Fernando J

“…Cancer‐associated mucins show frequent alterations of oligosaccharide chain profile. Terminal structures may be deleted, thereby exposing normally ‘cryptic’…”
Get full text

Catalytic and glycan-binding abilities of ppGalNAc-T2 are regulated by acetylation by Zlocowski, Natacha, Sendra, Victor G., Lorenz, Virginia, Villarreal, Marcos A., Jorge, Alberto, Núñez, Yolanda, Bennett, Eric P., Clausen, Henrik, Nores, Gustavo A., Irazoqui, Fernando J.

“…► Glycosyltransferase activity of ppGalNAc-T2 was reduced by acetylation. ► Acetylation of ppGalNAc-T2 enhances the recognition to αGalNAc of MUC1αGalNAc. ►…”
Get full text

Novel antibodies reacting with two neighboring gangliosides are induced in rabbits immunized with bovine brain gangliosides by Moyano, Ana L, Comín, Romina, Vilcaes, Aldo A, Funes, Samanta C, Roth, Germán A, Irazoqui, Fernando J, Nores, Gustavo A

“…Immunization of rabbits with bovine brain gangliosides induced an experimental neuropathy, with clinical signs resembling Guillain-Barré syndrome. All the…”
Get full text

Glycan bioengineering in immunogen design for tumor T antigen immunotargeting by Sendra, Victor G., Zlocowski, Natacha, Ditamo, Yanina, Copioli, Silvina, Tarp, Mads P., Bennett, Eric P., Clausen, Henrik, Roth, German A., Nores, Gustavo A., Irazoqui, Fernando J.

“…Bioengineering of Galβ3GalNAcα, known as Thomsen–Friedenreich disaccharide (TFD), is studied to promote glycan immunogenicity and immunotargeting to tumor T…”
Get full text