Search Results - "Nordstrom, Fredrik L"

Material Impurity Distribution of Lattice-Incorporated Impurities in Salicylic Acid by Teerakapibal, Rattavut, Li, Huayu, Linehan, Brian, Nordstrom, Fredrik L

“…The mechanisms of purging structurally similar impurities in solution crystallization have been evaluated using the model compound salicylic acid. Of the 11…”
Get full text

Formation of Macrotubular Crystals of Salicylic Acid through Ripening of Solid Solution Crystals Containing Impurity Gradients by Wang, Yongjian, Li, Huayu, Raikes, Michelle, Linehan, Brian, Robson, John, Nordstrom, Fredrik L

“…We report a ripening mechanism in crystallization of an organic compound that is observable above 1 μm and is different from Ostwald ripening. Salicylic acid…”
Get full text

Solubility-Limited Impurity Purge in Crystallization by Nordstrom, Fredrik L, Linehan, Brian, Teerakapibal, Rattavut, Li, Huayu

“…Crystallization from solution is a key unit operation utilized across the synthetic scheme to remove impurities. However, little is still known of the…”
Get full text

Probing the Molecular and Macroscopic Structure of Solid Solutions by Dynamic Nuclear Polarization (DNP) Enhanced 13C and 15N Solid-State NMR Spectroscopy by Mi, Jiashan, Chen, Yunhua, Atterberry, Benjamin A., Nordstrom, Fredrik L., Hirsh, David A., Rossini, Aaron J.

“…Crystallization is a widely used purification technique in the manufacture of active pharmaceutical ingredients (APIs) and precursor molecules. However, when…”
Get full text

Probing the Molecular and Macroscopic Structure of Solid Solutions by Dynamic Nuclear Polarization (DNP) Enhanced 13 C and 15 N Solid-State NMR Spectroscopy by Mi, Jiashan, Chen, Yunhua, Atterberry, Benjamin A, Nordstrom, Fredrik L, Hirsh, David A, Rossini, Aaron J

“…Crystallization is a widely used purification technique in the manufacture of active pharmaceutical ingredients (APIs) and precursor molecules. However, when…”
Get full text

Quantitative Impurity Rejection Analysis for Crystallization by Caspi, Daniel D, Nordstrom, Fredrik L

“…The analysis of impurity profiles is one of the most frequently performed activities in drug development. While mass-based quantification using a reference…”
Get full text

Investigation of Nucleation under High-Shear Conditions for a Pharmaceutical Compound in an Unseeded System by Martin-Soladana, Pablo M, Diwan, Moiz, Li, Huayu, Nordstrom, Fredrik L, Sheikh, Ahmad

“…The effect of in situ high energy mixing on primary nucleation of an active pharmaceutical compound (ABT-089) has been investigated by measuring the induction…”
Get full text

Correction to “Quantitative Impurity Rejection Analysis for Crystallization” by Caspi, Daniel D, Nordstrom, Fredrik L

Get full text

Solubility of Benzoic Acid in Pure Solvents and Binary Mixtures by Thati, Jyothi, Nordström, Fredrik L, Rasmuson, Åke C

“…The solubility of benzoic acid has been determined in ethanol, toluene, heptane, cyclohexane, pentane, and chloroform and in binary mixtures of ethanol +…”
Get full text

Prediction of solubility curves and melting properties of organic and pharmaceutical compounds by NORDSTROM, Fredrik L, RASMUSON, Ake C

“…The relationships between solubility, temperature dependence of solubility, melting temperature and melting enthalpy are investigated for the purpose of…”
Get full text

Influence of Solution Thermal and Structural History on the Nucleation of m‑Hydroxybenzoic Acid Polymorphs by Nordström, Fredrik L, Svärd, Michael, Malmberg, Baldur, Rasmuson, Åke C

“…The influence of solution pretreatment on primary nucleation of m-hydroxybenzoic acid has been investigated through 550 cooling crystallization experiments…”
Get full text

Thermodynamics and Nucleation Kinetics of m-Aminobenzoic Acid Polymorphs by Svärd, Michael, Nordström, Fredrik L, Jasnobulka, Tanja, Rasmuson, Åke C

“…The polymorphism of m-aminobenzoic acid has been investigated. Two polymorphs have been identified and characterized by X-ray powder diffraction (XRPD),…”
Get full text

Solubility and Melting Properties of Salicylic Acid by NORDSTRÖM, Fredrik L, RASMUSON, Ake C

“…The solubility of salicylic acid has been investigated in methanol, acetonitrile, acetic acid, acetone, water, and ethyl acetate from (10 to 50) °C. No new…”
Get full text

Determination of the activity of a molecular solute in saturated solution by NORDSTRÖM, Fredrik L, RASMUSON, Ake C

“…Prediction of the solubility of a solid molecular compound in a solvent, as well as, estimation of the solution activity coefficient from experimental…”
Get full text

Polymorphism and thermodynamics of m-hydroxybenzoic acid by Nordström, Fredrik L, Rasmuson, Ake C

“…Solution and solid-state properties of m-hydroxybenzoic acid have been investigated. Two polymorphs were found where the monoclinic modification exhibits a…”
Get full text

Dirty Nucleation of Salicylic Acid by Nordstrom, Fredrik L., Wang, Yongjian

Get full text

Phase equilibria and thermodynamics of p-hydroxybenzoic acid by Nordström, Fredrik L, Rasmuson, Ake C

“…The prevalence of phases and associated solubilities of p-hydroxybenzoic acid have been investigated in methanol, acetonitrile, acetic acid, acetone, water,…”
Get more information

Solubility and Melting Properties of Salicylamide by NORDSTRÖM, Fredrik L, RASMUSON, Ake C

“…The solubility of salicylamide in methanol, acetonitrile, acetic acid, acetone, water, and ethyl acetate has been determined between (10 to 50) °C. The onset…”
Get full text

Advanced Mercury Removal from Gold Leachate Solutions Prior to Gold and Silver Extraction:  A Field Study from an Active Gold Mine in Peru by Matlock, Matthew M, Howerton, Brock S, Van Aelstyn, Mike A, Nordstrom, Fredrik L, Atwood, David A

“…Mercury contamination in the Gold−Cyanide Process (GCP) is a serious health and environmental problem. Following the heap leaching of gold and silver ores with…”
Get full text

Thermodynamic Stability Transitions and Coexistence of Two Polymorphs via Crystalline Solid Solutions: The T‑X Phase Diagram of Salicylic Acid and 2,3-Dihydroxybenzoic Acid by Mohajerani, Seyed Sepehr, Paolello, Mitchell, Linehan, Brian, Ricci, Francesco, Capellades, Gerard, Nordstrom, Fredrik L.

“…The thermodynamically stable phases of salicylic acid (SA) and 2,3-dihydroxybenzoic acid (23DHBA) have been determined experimentally in a T-X phase diagram…”
Get full text