Search Results - "Nordstrand, Line M."
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Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects
Published in PloS one (03-11-2010)“…Escherichia coli AlkB is a 2-oxoglutarate- and iron-dependent dioxygenase that reverses alkylated DNA damage by oxidative demethylation. Mouse AlkB homolog 1…”
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2
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA
Published in The EMBO journal (17-05-2006)“…Two human homologs of the Escherichia coli AlkB protein, denoted hABH2 and hABH3, were recently shown to directly reverse 1‐methyladenine (1meA) and…”
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3
AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA
Published in Cancer research (Chicago, Ill.) (01-06-2008)“…Endogenous formation of the mutagenic DNA adduct 1,N(6)-ethenoadenine (epsilon A) originates from lipid peroxidation. Elevated levels of epsilon A in…”
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4
ALKBH1 is a Histone H2A Dioxygenase Involved in Neural Differentiation
Published in Stem cells (Dayton, Ohio) (01-12-2012)“…AlkB homolog 1 (ALKBH1) is one of nine members of the family of mammalian AlkB homologs. Most Alkbh1−/− mice die during embryonic development, and survivors…”
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DNA repair is indispensable for survival after acute inflammation
Published in The Journal of clinical investigation (01-07-2012)“…More than 15% of cancer deaths worldwide are associated with underlying infections or inflammatory conditions, therefore understanding how inflammation…”
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Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes
Published in Nucleic acids research (01-11-2012)“…Piwi proteins and Piwi-interacting small RNAs (piRNAs) have known functions in transposon silencing in the male germline of fetal and newborn mice. Both are…”
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Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V
Published in Nucleic acids research (15-07-2003)“…Deamination of DNA bases can occur spontaneously, generating highly mutagenic lesions such as uracil and hypoxanthine. In Escherichia coli two enzymes initiate…”
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8
AlkB homolog 2 (ABH2) mediated repair of ethenoadenine lesions in mammalian DNA
Published in Cancer research (Chicago, Ill.) (01-06-2008)“…Endogenous formation of the mutagenic DNA adduct 1, N 6 -ethenoadenosine (εA) originates from lipid peroxidation. Elevated levels of εA in cancer-prone tissues…”
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