Search Results - "Nordling, Kerstin"

Carbonic anhydrase generates CO2 and H+ that drive spider silk formation via opposite effects on the terminal domains by Andersson, Marlene, Chen, Gefei, Otikovs, Martins, Landreh, Michael, Nordling, Kerstin, Kronqvist, Nina, Westermark, Per, Jörnvall, Hans, Knight, Stefan, Ridderstråle, Yvonne, Holm, Lena, Meng, Qing, Jaudzems, Kristaps, Chesler, Mitchell, Johansson, Jan, Rising, Anna

“…Spider silk fibers are produced from soluble proteins (spidroins) under ambient conditions in a complex but poorly understood process. Spidroins are highly…”
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Efficient protein production inspired by how spiders make silk by Kronqvist, Nina, Sarr, Médoune, Lindqvist, Anton, Nordling, Kerstin, Otikovs, Martins, Venturi, Luca, Pioselli, Barbara, Purhonen, Pasi, Landreh, Michael, Biverstål, Henrik, Toleikis, Zigmantas, Sjöberg, Lisa, Robinson, Carol V., Pelizzi, Nicola, Jörnvall, Hans, Hebert, Hans, Jaudzems, Kristaps, Curstedt, Tore, Rising, Anna, Johansson, Jan

“…Membrane proteins are targets of most available pharmaceuticals, but they are difficult to produce recombinantly, like many other aggregation-prone proteins…”
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High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain by Abelein, Axel, Chen, Gefei, Kitoka, Kristīne, Aleksis, Rihards, Oleskovs, Filips, Sarr, Médoune, Landreh, Michael, Pahnke, Jens, Nordling, Kerstin, Kronqvist, Nina, Jaudzems, Kristaps, Rising, Anna, Johansson, Jan, Biverstål, Henrik

“…During storage in the silk gland, the N-terminal domain (NT) of spider silk proteins (spidroins) keeps the aggregation-prone repetitive region in solution at…”
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Degree of Biomimicry of Artificial Spider Silk Spinning Assessed by NMR Spectroscopy by Otikovs, Martins, Andersson, Marlene, Jia, Qiupin, Nordling, Kerstin, Meng, Qing, Andreas, Loren B., Pintacuda, Guido, Johansson, Jan, Rising, Anna, Jaudzems, Kristaps

“…Biomimetic spinning of artificial spider silk requires that the terminal domains of designed minispidroins undergo specific structural changes in concert with…”
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High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C by Willander, Hanna, Askarieh, Glareh, Landreh, Michael, Westermark, Per, Nordling, Kerstin, Keränen, Henrik, Hermansson, Erik, Hamvas, Aaron, Nogee, Lawrence M., Bergman, Tomas, Saenz, Alejandra, Casals, Cristina, Åqvist, Johan, Jörnvall, Hans, Berglund, Helena, Presto, Jenny, Knight, Stefan D., Johansson, Jan

“…BRICHOS domains are encoded in > 30 human genes, which are associated with cancer, neurodegeneration, and interstitial lung disease (ILD). The BRICHOS domain…”
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Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains by Otikovs, Martins, Chen, Gefei, Nordling, Kerstin, Landreh, Michael, Meng, Qing, Jörnvall, Hans, Kronqvist, Nina, Rising, Anna, Johansson, Jan, Jaudzems, Kristaps

“…Conversion of spider silk proteins from soluble dope to insoluble fibers involves pH‐dependent dimerization of the N‐terminal domain (NT). This conversion is…”
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Structural Properties of Recombinant Nonrepetitive and Repetitive Parts of Major Ampullate Spidroin 1 from Euprosthenops australis: Implications for Fiber Formation by Hedhammar, My, Rising, Anna, Grip, Stefan, Martinez, Alejandra Saenz, Nordling, Kerstin, Casals, Cristina, Stark, Margareta, Johansson, Jan

“…Spider dragline silk proteins, spidroins, have a tripartite composition; a nonrepetitive N-terminal domain, a central repetitive region built up from many…”
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Systemic AA amyloidosis in the red fox (Vulpes vulpes) by Rising, Anna, Cederlund, Ella, Palmberg, Carina, Uhlhorn, Henrik, Gaunitz, Stefan, Nordling, Kerstin, Ågren, Erik, Ihse, Elisabet, Westermark, Gunilla T., Tjernberg, Lars, Jörnvall, Hans, Johansson, Jan, Westermark, Per

“…Amyloid A (AA) amyloidosis occurs spontaneously in many mammals and birds, but the prevalence varies considerably among different species, and even among…”
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Tissue Response to Subcutaneously Implanted Recombinant Spider Silk: An in Vivo Study by Fredriksson, Camilla, Hedhammar, My, Feinstein, Ricardo, Nordling, Kerstin, Kratz, Gunnar, Johansson, Jan, Huss, Fredrik, Rising, Anna

“…Spider silk is an interesting biomaterial for medical applications. Recently, a method for production of recombinant spider silk protein (4RepCT) that forms…”
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The Brichos Domain-containing C-terminal Part of Pro-surfactant Protein C Binds to an Unfolded Poly-Val Transmembrane Segment by Johansson, Hanna, Nordling, Kerstin, Weaver, Timothy E., Johansson, Jan

“…Native lung surfactant protein C (SP-C) is a 4.2-kDa acylpeptide that associates with alveolar surfactant phospholipids via a transmembrane α-helix. This helix…”
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Degree of Biomimicry of Artificial Spider Silk Spinning Assessed by NMR Spectroscopy by Otikovs, Martins, Andersson, Marlene, Jia, Qiupin, Nordling, Kerstin, Meng, Qing, Andreas, Loren B., Pintacuda, Guido, Johansson, Jan, Rising, Anna, Jaudzems, Kristaps

“…Biomimetic spinning of artificial spider silk requires that the terminal domains of designed minispidroins undergo specific structural changes in concert with…”
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A Novel Anti-angiogenic Form of Antithrombin with Retained Proteinase Binding Ability and Heparin Affinity by Larsson, Helena, Åkerud, Peter, Nordling, Kerstin, Raub-Segall, Elke, Claesson-Welsh, Lena, Björk, Ingemar

“…Latent antithrombin, an inactive antithrombin form with low heparin affinity, has previously been shown to efficiently inhibit angiogenesis and tumor growth…”
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Self-assembly of spider silk proteins is controlled by a pH-sensitive relay by Saenz, Alejandra, Nordling, Kerstin, Askarieh, Glareh, Knight, Stefan D, Hedhammar, My, Johansson, Jan, Casals, Cristina, Rising, Anna

“…Nature's high-performance polymer, spider silk, consists of specific proteins, spidroins, with repetitive segments flanked by conserved non-repetitive domains…”
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Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation by Kronqvist, Nina, Otikovs, Martins, Chmyrov, Volodymyr, Chen, Gefei, Andersson, Marlene, Nordling, Kerstin, Landreh, Michael, Sarr, Médoune, Jörnvall, Hans, Wennmalm, Stefan, Widengren, Jerker, Meng, Qing, Rising, Anna, Otzen, Daniel, Knight, Stefan D., Jaudzems, Kristaps, Johansson, Jan

“…The mechanisms controlling the conversion of spider silk proteins into insoluble fibres, which happens in a fraction of a second and in a defined region of the…”
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pH‐Dependent Dimerization of Spider Silk N-Terminal Domain Requires Relocation of a Wedged Tryptophan Side Chain by Jaudzems, Kristaps, Askarieh, Glareh, Landreh, Michael, Nordling, Kerstin, Hedhammar, My, Jörnvall, Hans, Rising, Anna, Knight, Stefan D., Johansson, Jan

“…Formation of spider silk from its constituent proteins—spidroins—involves changes from soluble helical/coil conformations to insoluble β-sheet aggregates. This…”
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High intracellular stability of the spidroin N‐terminal domain in spite of abundant amyloidogenic segments revealed by in‐cell hydrogen/deuterium exchange mass spectrometry by Kaldmäe, Margit, Leppert, Axel, Chen, Gefei, Sarr, Medoune, Sahin, Cagla, Nordling, Kerstin, Kronqvist, Nina, Gonzalvo‐Ulla, Marta, Fritz, Nicolas, Abelein, Axel, Laίn, Sonia, Biverstål, Henrik, Jörnvall, Hans, Lane, David P., Rising, Anna, Johansson, Jan, Landreh, Michael

“…Proteins require an optimal balance of conformational flexibility and stability in their native environment to ensure their biological functions. A striking…”
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Anti-Amyloid Activity of the C-Terminal Domain of proSP-C against Amyloid β-Peptide and Medin by Nerelius, Charlotte, Gustafsson, Magnus, Nordling, Kerstin, Larsson, Annika, Johansson, Jan

“…Amyloid fibrils are found in ∼25 different diseases, including Alzheimer’s disease. Lung surfactant protein C (SP-C) forms fibrils in association with…”
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Back Cover: Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains (ChemBioChem 12/2015) by Otikovs, Martins, Chen, Gefei, Nordling, Kerstin, Landreh, Michael, Meng, Qing, Jörnvall, Hans, Kronqvist, Nina, Rising, Anna, Johansson, Jan, Jaudzems, Kristaps

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Sterilized Recombinant Spider Silk Fibers of Low Pyrogenicity by Hedhammar, My, Bramfeldt, Hanna, Baris, Teodora, Widhe, Mona, Askarieh, Glareh, Nordling, Kerstin, Aulock, Sonja von, Johansson, Jan

“…We have recently shown that it is possible to recombinantly produce a miniature spider silk protein, 4RepCT, that spontaneously self-assembles into…”
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Mutations linked to interstitial lung disease can abrogate anti-amyloid function of prosurfactant protein C by Nerelius, Charlotte, Martin, Emily, Peng, Siwei, Gustafsson, Magnus, Nordling, Kerstin, Weaver, Timothy, Johansson, Jan

“…The newly synthesized proSP-C (surfactant protein C precursor) is an integral ER (endoplasmic reticulum) membrane protein with a single metastable polyvaline…”
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